AstraZeneca, Reloaded

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Normally, December is a quiet time in the markets -- the third-quarter earnings season has wound down, people are taking extended vacations, and nobody is really looking to make waves. Apparently, British pharmaceutical company AstraZeneca (NYSE: AZN) didn't get the memo. This company has been rather busy acquiring rights to new biotech drugs in development.

The latest development came Wednesday morning, when the company announced a partnering agreement with Winston-Salem, N.C.-based Targacept. The deal concerns TC-1734, a drug that acts on neuronal nicotine receptors and has shown promise in treating age-related memory impairment, Alzheimer's disease, and some other cognitive disorders.

Under the agreement, AstraZeneca will pay $10 million up front, another $20 million if or when phase 2 studies begin (presumably for an Alzheimer's indication), and about $26 million in research funding. Should Targacept hit all of the goals, the total potential payments amount to about $300 million, as well as double-digit royalties.

This announcement follows the news last week that AstraZeneca will pay $210 million to acquire British biotechnology company KuDOS and its phase 1 cancer drug. It also follows a recent deal with AtheroGenics (Nasdaq: AGIX) for an anti-atherosclerosis drug. In that deal, AstraZeneca agreed to pay $50 million up front and up to $1 billion in total for a phase 3 drug that offers the promise of a very different approach to preventing heart disease. Last but not least, AstraZeneca also reached an agreement worth up to $340 million with Protherics for an experimental sepsis-treatment drug.

This is pretty much exactly what I've been expecting large pharmaceutical companies to do -- particularly those like AstraZeneca with shaky pipelines. The catch here is that AstraZeneca is wading into some very murky waters. It has now signed agreements for drugs targeting Alzheimer's, atherosclerosis, and sepsis -- a murderer's row of indications that have a long and tortured legacy of high-profile failure in attempts to treat them. So while the success of any one of these drugs would deliver a potential blockbuster, success is far from a sure thing.

As for the stock, sentiment on pharmaceutical companies has certainly brightened a bit. Income Investor recommendation GlaxoSmithKline (NYSE: GSK), Lilly (NYSE: LLY), Schering-Plough (NYSE: SGP), and Wyeth (NYSE: WYE) -- like AstraZeneca -- are all very close to 52-week highs. For what it's worth, I view at least part of this trend as a correction of the overreaction we saw a while back, when investors indiscriminately sold out of the sector. At the bottom line, I'd say AstraZeneca is probably close to fair value -- making it not the most attractive stock in the sector, but not a horrible pick, either.

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Fool contributor Stephen Simpson has no financial interest in any stocks mentioned (that means he's neither long nor short the shares).

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Related Tickers

11/9/2009 4:02 PM
AZN $45.94 Up +0.96 +2.13%
AstraZeneca plc (A… CAPS Rating: ****
GSK $41.37 Up +0.85 +2.10%
GlaxoSmithKline pl… CAPS Rating: *****
LLY $35.32 Up +0.82 +2.38%
Eli Lilly & Co. CAPS Rating: ****
SGP $28.15 Down +0.00 +0.00%
Schering-Plough Co… CAPS Rating: ****
WYE $50.39 Down +0.00 +0.00%
Wyeth CAPS Rating: ***
AGIX $0.07 Down +0.00 +0.00%
ATHEROGENICS, INC. CAPS Rating: **

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