Wells Fargo (WFC -0.68%) is undoubtedly seen as the strongest big U.S. bank, but investors should always be reevaluating their positions to see if their investment thesis has changed. Knowing when to sell is always a difficult decision, but shareholders who can anticipate game-changing impacts are rewarded.

In this video, Motley Fool banking analysts David Hanson and Matt Koppenheffer discuss potential scenarios that might signal that its time to sell your shares of Well Fargo.