AstraZeneca (LSE: AZN) is expected to report Q1 earnings on April 25. Here's what Wall Street wants to see:

The 10-second takeaway
 Comparing the upcoming quarter to the prior-year quarter, average analyst estimates predict AstraZeneca's revenues will wither -10.8% and EPS will wane -24.9%.

The average estimate for revenue is $6.56 billion. On the bottom line, the average EPS estimate is $1.36.

Revenue details
 Last quarter, AstraZeneca reported revenue of $7.28 billion. GAAP reported sales were 16% lower than the prior-year quarter's $8.66 billion.

Source: S&P Capital IQ. Quarterly periods. Dollar amounts in millions. Non-GAAP figures may vary to maintain comparability with estimates.

EPS details
 Last quarter, non-GAAP EPS came in at $1.56. GAAP EPS of $1.22 for Q4 were 8.0% higher than the prior-year quarter's $1.13 per share.

Source: S&P Capital IQ. Quarterly periods. Non-GAAP figures may vary to maintain comparability with estimates.

Recent performance
 For the preceding quarter, gross margin was 81.6%, 130 basis points better than the prior-year quarter. Operating margin was 31.6%, much better than the prior-year quarter. Net margin was 20.9%, 370 basis points better than the prior-year quarter.

Looking ahead

The full year's average estimate for revenue is $26.37 billion. The average EPS estimate is $5.30.

Investor sentiment
 The stock has a five-star rating (out of five) at Motley Fool CAPS, with 46 members out of 51 rating the stock outperform, and five members rating it underperform. Among two CAPS All-Star picks (recommendations by the highest-ranked CAPS members), two give AstraZeneca a green thumbs-up, and give it a red thumbs-down.

Of Wall Street recommendations tracked by S&P Capital IQ, the average opinion on AstraZeneca is hold, with an average price target of $47.71.

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