Why Idera Pharmaceuticals, Inc. Shares Popped

A preclinical psoriasis publication sends Idera soaring. Should shareholders latch onto this third-party news or use it as an opportunity to take their profits?

Jan 22, 2014 at 2:52PM

Although we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.

What: Shares of Idera Pharmaceuticals (NASDAQ:IDRA), a clinical-stage biopharmaceutical company focused on developing DNA and RNA-based therapeutics for autoimmune diseases, advanced as much as 13% after announcing the publication of preclinical data with regard to treating psoriasis.

So what: According to Idera's press release, the publication, Suppression of Molecular Inflammatory Pathways by Toll-Like Receptor 7, 8, and 9 Antagonists in a Model of IL-23-Induced Skin Inflammation, noted in testing on mice that antagonists of TLR's 7 and 9 normalized expression of IL-17 induced genes, which are involved in the inflammatory pathway. Further analysis from this study showed all the TLR's (7, 8, and 9) "down-regulated the JAK-STAT, IL-23, IL-12, and IL-17 canonical pathways," resulting in a hypothesis that "IL-23-driven inflammation in mouse skin may be dependent on signaling mediated by TLR's 7, 8 and 9."

Now what: Without getting too scientific here, what the above data simply demonstrates is that inhibiting specific toll-like receptors in mice demonstrated efficacy that would suggest these TLR's could be a therapeutic target for the treatment of psoriasis. Idera is currently conducting a mid-stage trial involving IMO-8400, an antagonist of TLR's 7, 8, and 9 for the treatment of moderate-to-severe plague psoriasis, lending excitement that its study will deliver positive results. As for me, while I find this new treatment pathway exciting, I'd wait for the results from Idera's trial before even considering the thought of sending this wholly clinical-stage company's stock any higher.

Idera may be up big recently, but it'll likely have a hard time keeping up with this top stock!
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4 in 5 Americans Are Ignoring Buffett's Warning

Don't be one of them.

Jun 12, 2015 at 5:01PM

Admitting fear is difficult.

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This past May, The Motley Fool sent 8 of its best stock analysts to Omaha, Nebraska to attend the Berkshire Hathaway annual shareholder meeting. CEO Warren Buffett and Vice Chairman Charlie Munger fielded questions for nearly 6 hours.
The catch was: Attendees weren't allowed to record any of it. No audio. No video. 

Our team of analysts wrote down every single word Buffett and Munger uttered. Over 16,000 words. But only two words stood out to me as I read the detailed transcript of the event: "Real threat."

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David Hanson owns shares of Berkshire Hathaway and American Express. The Motley Fool recommends and owns shares of Berkshire Hathaway, Google, and Coca-Cola.We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.

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