Based on the aggregated intelligence of 180,000-plus investors participating in Motley Fool CAPS, the Fool's free investing community, biotechnology company Threshold Pharmaceuticals (Nasdaq: THLD) has received a distressing two-star ranking.

With that in mind, let's take a closer look at Threshold's business and see what CAPS investors are saying about the stock right now.

Threshold facts

Headquarters (founded) San Francisco, Calif. (2001)
Market Cap $430.5 million
Industry Biotechnology
Trailing-12-Month Revenue $314.0 thousand
Management Chairman/CEO Dr. Harold Selick (since 2002)
Principal Financial Officer Joel Fernandes (since 2007)
Return on Assets (average, past 3 years) (37.0%)
Cash/Debt $49.7 million / $0
Competitors Eli Lilly
Pfizer

Sources: S&P Capital IQ and Motley Fool CAPS.

On CAPS, 23% of the 101 members who have rated Threshold believe the stock will underperform the S&P 500 going forward.

Just yesterday, one of those bears, All-Star zzlangerhans, tapped the stock as a particularly risky proposition:

Rising summer tides have bought Threshold back close to recent highs seen shortly after the company partnered TH-302 with Merck KGaA and then reported significant [progression-free survival] improvement in [pancreatic cancer] in trial 404. Those tides have left the stock vulnerable to a sharp decline if the OS data from the same trial to be reported this half don't match lofty expectations.

If you want market-thumping returns, you need to put together the best portfolio you can. Owning exceptional stocks is a surefire way to secure your financial future. Threshold, with its two-star rating, may not fit the bill for your portfolio.

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Want to see how well (or not so well) the stocks in this series are performing? Follow the TrackPoisedTo CAPS account.