Gunning for a Multibillion-Dollar Blockbuster

Selling $7.9 billion worth of a drug annually has put a target on the back of Abbott Labs' (NYSE: ABT  ) Humira. Two companies presented data from head-to-head trials pitting their drugs against Humira at the European League Against Rheumatism annual meeting.

Bristol-Myers Squibb's (NYSE: BMY  ) Orencia proved just as effective as Humira at treating patients with rheumatoid arthritis. After one year of treatment, 64.8% of patients taking Orencia plus a generic called methotrexate saw their symptoms improve by 20% compared to 63.4% of patients taking Humira plus methotrexate.

Being just as good as the leader might seem like a win, but I'm not sure it'll be enough to capture a large chunk of Humira's market share. On a whole, Orencia appears to have a better safety profile; only 3.5% of patients taking Orencia dropped out of the study because of adverse events compared to 6.1% for Humira patients. But Orencia had more autoimmune events, which are likely drug-related since the drugs work by tempering the overactive immune system that causes the rheumatoid arthritis attacks.

More worrisome for Abbott is Roche's Actemra, which goes by RoActemra in Europe. The drug didn't just match Humira, it actually beat it. Using the same scale as the Orencia trial, Actemra improved symptoms in 65% of patients compared to just 49% of Humira-treated patients.

That's a solid win for Actemra, but don't expect prescription habits to change overnight. Doctors are comfortable with Humira, as witnessed by the nearly $8 billion in sales last year, which gives the drug a distinct advantage compared to Actemra, which just gained U.S. approval in 2010. In fact, Roche will have to get the new data added to the label before it can market Actemra as a direct competitor to Humira. The drug is currently approved as a treatment for patients who have failed a TNF inhibitor, a class that includes Humira, Pfizer (NYSE: PFE  ) and Amgen's (Nasdaq: AMGN  ) Enbrel, and Johnson & Johnson's (NYSE: JNJ  ) Remicade.

While the injected and infused drugs are all fighting for market share among themselves, Pfizer is hoping to move into the market with its oral rheumatoid arthritis treatment, tofacitinib. After a solid 8-2 vote from a Food and Drug Administration advisory committee, an approval in August looks likely. Like Actemra, tofacitinib might be initially approved as a post-TNF-inhibitor treatment, which will take one of the targets off Humira's back at least for a little while.

Dividends can help investors ride the waves of slow drug development times. Check out the Fool's new free report "Secure Your Future With 9 Rock-Solid Dividend Stocks," where you'll find one drug developer and eight other promising companies. Just click here to get your free copy.

Fool contributor Brian Orelli holds no position in any company mentioned. Click here to see his holdings and a short bio. The Motley Fool owns shares of Abbott Laboratories and Johnson & Johnson. Motley Fool newsletter services have recommended buying shares of Pfizer and Johnson & Johnson. Motley Fool newsletter services have recommended creating a diagonal call position in Johnson & Johnson. The Motley Fool has a disclosure policy. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. Try any of our Foolish newsletter services free for 30 days.


Read/Post Comments (0) | Recommend This Article (3)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

Be the first one to comment on this article.

Sponsored Links

Leaked: Apple's Next Smart Device
(Warning, it may shock you)
The secret is out... experts are predicting 458 million of these types of devices will be sold per year. 1 hyper-growth company stands to rake in maximum profit - and it's NOT Apple. Show me Apple's new smart gizmo!

DocumentId: 1904931, ~/Articles/ArticleHandler.aspx, 9/15/2014 5:54:15 AM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...


Advertisement