The NIH is Investing in an Alzheimer's Cure; Should You?http://www.fool.com/investing/general/2014/03/14/the-nih-is-investing-in-an-alzheimers-cure-should.aspx Seth Robey
March 14, 2014
Last month the Senate Appropriations Subcommittee on Labor, Health, and Human Services held a hearing to discuss federal budgeting for Alzheimer's Disease research. While much noise has been made about committee members choosing not to attend Seth Rogen's heartfelt testimony, media reports fail to mention the enlightening testimonies of top scientists for which the committee was more engaged. The testimony of NIH Director Dr. Francis Collins, for example, contained some poignant remarks that highlight our still nascent understanding of the disease, and could inform decisions to invest in a cure for Alzheimer's.
That cure will be ever more in demand as the population continues to age, bringing with it a burden on patients, their families, and society. A recent report places Alzheimer's as the third leading cause of death in the US following heart disease and cancer. With that demand in mind, a supplement to the new federal budget allocates $970 million to the NIH earmarked for Alzheimer's research. So if the NIH is investing in a cure, is it time for you to as well?
Barking up the wrong tree
Despite these tribulations calling into question the validity of the amyloid-beta hypothesis, a new approach to preventing plaque formation has gained the attention of well funded development programs. Merck (NYSE: MRK) and AstraZeneca are two leading players in the race to block the BACE enzyme responsible for a step in the production of amyloid beta, after Lilly and Roche faced separate disappointments with their own BACE inhibitors. Merck has the upper hand in the field, with its MK-8931 in a Phase 2/3 trial for the mild and moderate forms of the disease and a Phase 3 trial for prodromal Alzheimer's. While the Phase 2 interim data suggest that safety is not an issue, the real question will be if the drug can slow cognitive decline more effectively than earlier therapies.
Not to be left out of this Who's Who in health care, Biogen has entered the race with a deal to collaborate on Eisai's E2609. That deal brings together two neurology powerhouses, and I think the partnership is likely to forge the most innovative therapies in the bunch.
The need to refocus efforts