Integra Lifesciences Holdings Corp (IART) Q4 2020 Earnings Call Transcript

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Integra Lifesciences Holdings Corp (IART -9.33%)
Q4 2020 Earnings Call
Feb 18, 2021, 8:30 a.m. ET

Contents:

• Prepared Remarks
• Questions and Answers
• Call Participants

Prepared Remarks:

Operator

Good day and welcome to the Integra LifeSciences Fourth Quarter and Full Year 2020 Financial Results Call. Today's conference is being recorded, and at this time, I would like to turn the conference over to Michael Beaulieu, Director Investor Relations. Please go ahead, sir.

Michael Beaulieu -- Director of Investor Relations

Thank you, Catherine. Good morning and thank you for joining the Integra LifeSciences Fourth Quarter and Full Year 2020 Earnings Conference call. Joining me on the call are Peter Arduini, President and Chief Executive Officer, Glenn Coleman, Chief Operating Officer and Carrie Anderson, Chief Financial Officer.

Earlier today we issued a press release announcing our fourth quarter and full year 2020 financial results. The release and corresponding earnings presentation, which we will reference during the call are available at integralife.com under Investors, Events and Presentations in the file named Fourth Quarter and Full Year 2012 Earnings Call Presentation. Before we begin, I'd like to remind you that many of the statements made during this call may be considered forward-looking statements. Factors that could cause actual results to differ materially are discussed in the Company's Exchange Act reports filed with the SEC and in the release.

Lastly, our comments today will include certain non-GAAP financial measures, reconciliations of any non-GAAP financial measures can be found in today's press release, which is an exhibit to Integra's current report on Form 8-K filed today with the SEC. With that, I'll now turn the call over to Pete.

Peter Arduini -- President & Chief Executive Officer

Thank you, Mike and good morning everyone. If you'll turn to slide 4, I'll begin with a review of our performance in 2020. Full-year 2020 revenues declined 8.7% on an organic basis to $1.37 billion and adjusted earnings declined 11% to $2.45. These declines were a direct result of COVID-related surgical procedure deferrals and capital spending delays at hospitals. To put our 2020 performance in perspective and illustrate the impact of the pandemic, we've included a side by side comparison of revenue and profitability in the first and second half of the year.

The biggest impact from COVID was felt during April and May, and as a result, first half organic revenues were down 16% and earnings were down 40% compared to the first half of 2019. As we've discussed on prior calls, we reacted swiftly to the pandemic prioritizing the safety of our employees while implementing protocols to ensure continuity of our supply chain and key R&D and clinical programs. We also protected our financial position by managing costs down sharply.

As the recovery begins to take hold, we saw the benefit of our balanced pandemic response. In the second half, we continue to methodically manage expenses while allocating additional funds toward growth and productivity related projects. We generated $150 million in operating cash flow, invested in inventory and improved our leverage ratio from 3.4 times in June to 3 times at the end of the year. We reshaped our portfolio with the divestiture of orthopedics in the acquisition of ACell. Our second half revenues increased $146 million compared to the first half, inorganic revenues declined only 1.5% year-over-year.

In the second half EBITDA sequentially increased $77 million and earnings per share increased 20% year-over-year. Our sales recovery persisted despite localized COVID surges and locked downs in the fourth quarter driven by market-leading products such as Integra skin, DuraGen as well as our service portfolio of programmable valves all of which returned to growth in the fourth quarter.

If you turn to slide 5, you can see that we used 2020 as an opportunity to reinvest the company. In addition to the strong financial recovery in the second half of the year, we took action that positioned us to accelerate growth in 2021 and beyond. So, throughout the pandemic our focus has always been on our employees and patients, making sure we could supply critical products while keeping our employees safe. We have a one-team mindset coming together to do the right things to shore up the debtors. As a management team on the pandemic first hit we acted quickly to prioritize the most important asset, our people. At the same time we challenged our employees to reimagine how they would do their jobs in a virtual environment. We provided tools and resources and they rose to the occasion. Our people made our strong recovery possible.

Moving to Global operations, we completed investments solidifying our tissue supply and also adapted to numerous logistical challenges posed by the pandemic. We quickly implemented rigorous and consistent protocols across our sites to ensure both the safety of employees and continuity of product supply. In 2020, we closed 5 sites as part of our optimization program that will help us reach our long-term profitability targets. COVID challenged, but it did not impede the progress within our R&D organization. On previous earning calls we discussed how we maintained investments in critical growth programs such as The Aurora surgery scope keeping them on track with their original development timelines in spite of the pandemic.

Moving to the sales force capabilities, our commercial organizations rapidly adopted a variety of virtual collaboration and digital marketing mechanisms to stay connected with our customers and to ensure adequate support to patients.

Turning to portfolio optimization, as I mentioned, our two most transform of actions were the divestiture of our orthopedics business and the acquisition of ACell. The combination of the two of these creates a highly focused tissue technology segment that will be accretive to growth and profitability and will advance our leadership positions across the portfolio. We achieved all of these accomplishments while strengthening our balance sheet and increasing our financial agility.

And finally, during 2020, we benefited greatly from prior investments in our information systems, infrastructure and accelerated our digital transformation within many parts of the company. So, as you can see we did not sit still during the pandemic, we utilized the time to position the company for success in 2021 and beyond, and I'm proud of the way our colleagues responded. We are a stronger, more focused company today than when we entered 2020.

Now I'd like to turn the call over to Carrie for more detailed review of our fourth quarter performance and guidance for 2021. Carrie?

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Thanks, Pete and good morning everyone.

I'd like to start with a brief summary of our fourth quarter highlights on slide 6. Fourth quarter total revenues were $388.6 million representing a decline of 1.6 on a reported basis and a decline of 1.5% on an organic basis. Our revenue performance was at the high end of our preliminary range communicated on January 14th. During the quarter COVID surges affected many of our markets resulting in tight ICU bed capacity, but we still managed a 5% improvement in our fourth quarter sales compared to the third quarter. Most of our franchises or products that return to growth in the third quarter sustained that growth into Q4. Sales of capital equipment improved sequentially by over 40%, but we're still down on a year-over-year basis. As we have discussed on prior earnings calls, recovery of capital was expected to lag the rest of the portfolio. So, if we exclude capital, total organic growth was flat in Q4 compared to the prior year. Fourth quarter performance in the US was also flat on an organic basis compared to 2019. By segment US CSS organic growth increased about 2% if we exclude capital and US OTT organic growth was about flat excluding orthopedics. We were also quite pleased with our profitability performance in Q4 showing improvement year-over-year as we continue to manage our spending. Adjusted EBITDA margins in Q4 increased by 320 basis points to 26.4% and adjusted earnings per share increased 24% to $0.84.

If you turn to slide 7, I'll now review the fourth quarter performance of our CSS segment. Reported Q4 revenues were $254 million, a decrease of 1.6% on an organic basis from the prior year. Global neurosurgery sales improved sequentially from the third quarter and were down 1.3% on an organic basis year-over-year. Sales in dural access and repair and CSS management increased low-single digits and mid-single digits respectively. Sales in neuromonitoring increased low-double digits in Q4. All three franchises benefited from strong sales of market-leading products including DuraGen, antimicrobial catheters and service programmable valves. Sales in Advanced Energy, which includes our CUSA capital sales were down mid-teens in the fourth quarter in line with expectations, importantly sales of consumables directly tied to our CUSA equipment increased low-single digits in Q4, a sequential improvement from the third quarter. Our sales funnel of capital opportunities is strong and we remain confident in our competitive positioning. However, we do expect capital budgets will continue to be constrained through the first half of 2021 until hospitals have more certainty around COVID. Q4 sales in our instruments franchise increased sequentially high single digits from Q3, but still far, a slight 2% decline on the organic basis year-over-year. International sales in CSS were down low-single digits in the quarter with mixed performance. In Q4 we saw a return to growth in several European countries, revenues in both China in Japan increased low-double digits. However, this was offset by a slower recovery in our indirect markets.

Moving to the OTT segment slide on slide 8, revenues were $134 million representing a decline of 1% on a reported basis and a decline of 1.3% on an organic basis. Q4 sales in wound reconstruction declined 1.5% versus the prior year, but sales of SurgiMend, nerve and amniotic all increased double digits and sales of Integra skin increased low-single digits. Fourth quarter sales in private label increased 2% in line with expectations. Orthopedic sales declined mid-single digits in the fourth quarter, and as a reminder, we closed the divestiture of the ortho business on January 4th of this year.

Turning to slide now 9. I will now show you our fourth quarter performance of the key P&L components. Adjusted gross margin was 68.2% compared to 67.2% in the fourth quarter of 2019. Gross margins benefited from cost management, stronger performance in the US and favorable product mix. Our adjusted EBITDA margin was 26.4% compared to 23.2% in Q4 of 2019, driven by improved gross margins and ongoing cost management measures. Operating expenses were approximately $12 million below prior year levels. Fourth quarter GAAP EPS was $1.9 compared to $0.18 in the prior year. The increase was largely driven by a $59 million one-time benefit driven by tax restructuring completed during the quarter. Adjusted EPS was $0.84 in the fourth quarter compared to $0.68 in the prior year, reflecting an increase of over 23%. Diluted shares outstanding were down slightly in the fourth quarter as a result of the accelerated share repurchase program completed earlier this year.

Turning to slide 10. I'll now review cash flow performance. Operating cash flow was approximately $80 million in the fourth quarter and just over $200 million for the full year. Free cash flow conversion for the full year reached almost 80%, driven by strong second half EBITDA performance, improved receivable collection efforts and prioritization of capital expenditures.

If you turn to slide 11. I'll provide a brief update on our capital structure. We ended the year with a strong balance sheet, our cash balance was $470 million with an improvement of $140 million in our net debt position from 2019, the proforma levels inclusive of the convertible notes. This translated into a leverage ratio of 3.0 times basically flat with 2019 on a proforma basis. Our targeted leverage ratio range at 2.5 to 3.5 times. So, we were right in the middle of this window. To call that in the second quarter of 2020 We reached our peak ratio for the year at 3.4 times, so our second half cash flow moved out squarely within the range by year-end.

Turning to slide 12, I'll provide an overview of our consolidated revenue and adjusted earnings per share guidance for the first quarter and full year 2021. We are providing guidance today, but recognize that the course of the pandemic remains uncertain, and as a result, the rate of recovery in surgical procedures and capital equipment sales remains variable. In our full year guidance, we assume a gradual improvement in procedures in the first half with no further setbacks from new surges or new COVID variance. And, as mentioned earlier, we believe capital budgets will continue to be constrained in the first half of 2021. We will continue to assess the current environment and provide updates on our quarterly calls. This quarter revenues are forecasted to be in the range of $345 million to $355 million representing our normal seasonality in Q1. This represents reported growth of approximately -3% to flat and organic growth of flat to up 3% over 2020. For the full year 2021, we expect revenues to be in the range of $1.520 billion to $1.535 billion representing reported growth of 11% to 12% and organic growth of 12% to 13% over 2020. Reported revenues included first quarter estimate for ACell in the range of $14 million to $15 million and a full-year estimate in the range of $83 million to $88 million. This estimate is based on 2020 ACell revenues of $95 million and a late January closing. We also assume that continuing COVID impact for ACell similar to our existing tissue business as well as typical short-term sales disruptions as we integrate the business. As a reminder, 2021 organic growth excludes the impact of foreign currency fluctuations, acquired revenues including ACell, divested revenues including orthopedics and discontinued products, and consistent with previous practice, we will include a reconciliation between reported in organic growth. The impact from discontinued products is expected to continue to decline and will have a negative impact of approximately 1.3% on full-year 2021 reported revenue. As a reminder, 2021 should be the last year of any significant impact for product discontinuation. SKU rationalization has been an important part of how we are simplifying the portfolio and improving overall gross margins.

Turning to the earnings guidance for 2021, and based on the revenue ranges I just provided, we expect first quarter adjusted EPS to be in the range of $0.54 to $0.58 which represents double-digit year-over-year growth. Full year 2021 adjusted EPS is expected to be in the range of $2.86 to $2.93.

With that I'd like to turn the call over to Glenn.

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Thanks Carrie, and good morning.

If you turn to slide 13. I'll provide an update on the ACell integration. Mainly following the January 20th closing we began the implementation of our integration plans and onboarded conveying ACell colleagues. The first three weeks of the integration has largely been focused on the transition of the commercial organization. We've already taken steps to assign sales reps to their territories, formalized quotas and established rollout compensation plans. Integra and ACell sales reps also completed initial product training and are beginning to cross sell our expanded portfolio. Last week the Tissue Technologies team held a annual national sales training meeting with in-depth product training. While it's still early, the addition of the ACell portfolio and expansion of our tissue technology platform is generating positive customer feedback. The unique characteristics of porcine products like to MicroMatrix powder and the Gentrix Surgical Matrix help fill gaps in our portfolio to offer clinicians additional tool to treat the most challenging reconstructive interventions. It's only been a few weeks since we closed the ACell, but we remain confident in the positive financial impact and the returns on investment that will come from this acquisition. We expect it to be a quick integration with all critical activities completed by the end of the second quarter, including our ERP conversion to handle invoicing and distribution. We are excited to welcome new ACell colleagues to Integra and look forward to providing an integration update on our next quarterly call.

Turning to slide 14. I'd like to provide a summary of our 2021 growth drivers starting with new product introductions. Over the past two years, we launched about 7 new products in CSS which are expected to take several years to reach peak sales. Performance of all these products was negatively impacted by COVID during 2020. As the recovery takes hold many of these launches like our service portfolio of programmable valves and DuraGen in Japan should contribute to growth for CSS in 2021. In addition, during the second half of 2021 we're planning the global relaunch of CereLink, our next generation ICP monitor, which should immediately benefit our neuromonitoring franchise. Later in the year, we'll be launching our Aurora Surgiscope for minimally invasive treatment of brain tumors, an important part of our long-term growth plans. In our tissue technologies segment we completed investments that were necessary to increase our product supply and expand capacity at several of our regenerative plants in 2020. These investments will enable us to not only support our existing customers, but actively pursue new business.

Turning to our international markets. Japan, our largest country by revenue outside the US has achieved 6 consecutive quarters of double-digit revenue growth despite the impact of COVID. This growth has been driven by our leading neurosurgery portfolio, and as an example DuraGen is rapidly becoming the standard of care in dural grafting procedures. In 2020 during the height of the first wave of COVID, we also successfully launched a new surgical sales team and took our CUSA business direct in the general surgery market where we have a leadership position in liver surgery. With this transition, we've now converted nearly all of our business in Japan from a distributed model to a direct selling model. During 2021 we will be launching a number of new products including programmable valves that are specific to the Japan market, a generator, irrigator, and reusable bipolar forceps. We're also adding hydro specialists and leveraging clinical studies for back to seal. Taken together, these channel investments, new product introductions in our broad portfolio of leading products will drive further penetration into the neurosurgery market in Japan in 2021.

Turning to China, after the initial COVID locked out in February and March, neurosurgery procedures have steadily recovered. During 2020 we invested in professional education and market access for key products which helped drive low double-digit organic growth in the fourth quarter, giving us momentum as we begin 2021. We're expanding our commercial presence in China and recently entered into our first exclusive licensing and distribution deal with the local Chinese partner, which will result in the launch of new complementary products later this year. This partnership represents a great example of how we can fill a gap in our product portfolio while leveraging our large commercial channel.

On a global basis, we accelerated investments in digital capabilities that will enable our commercial teams to reach a broader customer base. We've added specialists in neuromonitoring, hydrocephalus and 7 regenerative areas. In 2020 we created an inside sales team within our OTT segment, which is a virtual selling organization focused on driving further growth. And finally with ACell we're bringing together two sales and R&D organizations with deep knowledge and broad experience in regenerative medicine. The ACell portfolio is a strong fit with our existing commercial infrastructure and call points.

If you turn to slide 15, I'd like to make some closing remarks. Despite the challenges of 2020 that we outlined at the beginning of the call, we took advantage of the current environment to strengthen the company's position and advance toward our long-term goals. COVID forced us to reimagine how we do our jobs, and as a result we optimized many of the functions and operations within the company. We also accelerated investments in critical programs to drive future growth. And with the divestiture of orthopedics and the addition of ACell, we have a more focused product portfolio. One of our key objectives last year was to emerge from the pandemic as a stronger company, and following our fourth quarter and full year results we believe we have succeeded. We remain confident in our long-term goals of 5% to 7% organic growth, greater than 70% gross margins, 28% to 30%, EBITDA margins, and double-digit adjusted earnings-per-share growth.

Before opening the line to Q&A, I'd like to close by announcing an exciting event we have planned. So please turn to slide 16. We'll be hosting a virtual Investor day on May 20th. Half the event will feature a thorough review of our strategies for both the Codman Specialty Surgical and Tissue Technologies segments and our path to generating 5% to 7% percent organic growth. We'll provide more information as we get closer to the date, and we hope you'll be able to join us.

That concludes our prepared remarks. We look forward to providing you with another update on our first quarter earnings call in April. Thank you for listening. Operator, would you please open the line for questions.

Questions and Answers:

Operator

Thank you. [Operator Instructions]. We'll now take the first question from Matt Miksic from Credit Suisse. Please go ahead.

Matt Miksic -- Credit Suisse -- Analyst

Good morning. Can you hear me OK?

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

We can.

Matt Miksic -- Credit Suisse -- Analyst

Thanks so much for taking our question. So one on just to add a bigger picture question on the regenerative med businesses, it's coming together and bigger business right now. And the other on and some of the trends you talked about in your guidance and outlook. So in the bigger picture perspective, can you talk a little bit about the sort of how you see in regenerative med platform that you have now, if they sell, what you see as some of the competitive advantages or opportunities there and maybe some of the synergies that you may be able to enjoy just putting more things, running more things across that sort of platform. And then I have one follow-up, as I mentioned,

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Yeah Matt, I'll comment and then Glenn, if you want to jump in after. I would say, I mean the first piece is, is that I think you know regenerative medicine is not a precise science, right, it's a little bit of art and it's a lot of science, and having multiple tools or different technologies in that toolkit we believe is a big deal, primarily because our clinicians tell itself. So a wound that's caused from pressure ulcer or caused from a vascular related issue or one that's caused by surgical intervention or one that is caused by trauma, all of those may have very different approaches. And so today, most of these reconstructive surgeons, plastics as well use different platforms already from different companies, but there really hasn't been a company that's had all of these together and I think today at this point in time, we have the most comprehensive portfolio. We may not have the largest share positions with all of them, but I think that's the opportunity that exists. And, particularly in the United States with the consolidating healthcare system, ANC's and such offices more people becoming part of bigger systems, we believe that contracting with world-class technologies will differentiate. And so, we have this large matrices structure I think then as we go further upstream, we're well positioned to add on to this portfolio with other products that play and potentially into the epidermis, other accelerants to help actually healing, and so we thought that we've got ACell particularly because of its fit within the acute space, but also growing area outside of that was a great fit, particularly for the granulated product that we had no version thereof. And I think that combined with what we think we'll be able to evolve in the portfolio with foreseeing is also there are new Head of R&D. Previously, was it ACell years back and has very good insight into that technology, actually did some of the original work from the University of Pittsburgh. So, we've got some very good retained knowledge as well and investment capabilities to not just have the current products, but to evolve those into a new portfolio.

Glenn, you may want to talk a little bit more even about trends and stuff that we see.

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Yeah, I would just say that first and foremost, when we think about our regenerative platform, it's broader than wound care right. So it's hitting other parts of the body as well and one nice thing about the ACell addition is it did add additional capability in wound care, but also in our plastic and reconstructive business with the Gentrix product. So, we are thinking broader in terms of regenerative medicines outside of wound care, and I think as we look forward, we'll be doing more in other adjacent areas of the body.

I feel, trending wise, obviously, our business has been impacted by COVID and we'll probably see additional impact here in the first quarter, maybe first half of the year, but we feel quite good about a few things. Number one, you remember last year we struggled with supply before COVID hit, I think we're in really good shape relative to our plans, and we've now built how the safety stock to support our existing customers, and as I mentioned in prepared remarks going after new accounts, and so, I think we're in a good position to capitalize a lot around that. And I said, I think once we bring this business together with ACell, we are expecting to see synergies. We'll talk more about what that looks like as we get further into the year, but on the commercial front, all the heavy lifting has been done and I think that's really good news that we've got that behind us, we're moving forward. The team has have been the trained on the combined product portfolio and we're really excited about just broader bag in toolkit that we now have to provide to our customers and ultimately to patients.

Matt Miksic -- Credit Suisse -- Analyst

Great, thanks so much and [Indecipherable] the follow-up question I have, on ACell, it's just the guidance that you've given includes obviously a partial Q1 and it sounded like some expectation as we'd expect for some sales disruption during integration. if I heard Carrie's comments correctly. Just, I hate to say exiting this year as nobody wants to talk about 2022 outlook at the moment, but just an underlying business, net of those kinds of effect as we get into the back half of the year and into the following year, how should we think about underlying growth for that ACell business we sold into the portfolio.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Carrie, do you want to since you commented in the prepared remarks, you want to frame it up a little bit?

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Yeah, I think in terms of growth expectations for ACell, I think we would expect it to be growing at the same level that we would expect the rest of our tissue business to be growing out. So, I think that the high-single digits, definitely is the expectation that we should all have as we get more confident with our 5% to 7% with ortho out and ACell coming into Tissue Technologies as well as what Glenn mentioned on the supply, I think that that entire segment has the ability to get back to high-single digits, low double digits for sure. And so, that's what that would be my same expectation for ACell.

Matt Miksic -- Credit Suisse -- Analyst

Thanks.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Thanks so much.

Operator

As a reminder, we are taking one question and one follow-up question on today's call. We'll now take the next question from Dave Turkaly from JMP Securities, please go ahead.

Dave Turkaly -- JMP Securities -- Analyst

Thanks. I was beginning to forget with guidance, was like and we got a quarter here and the full year. So thank you for that. Maybe one for future. I mean, obviously things are changing with the fluid world, but you mentioned some of your confidence. I'd love to get your thoughts on what's happening out there whether you want to talk domestically or internationally as well with the virus and sort of your confidence level, maybe compared to what it was in 2019 looking forward.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Yeah. Let me start it off, Glenn maybe you can frame it up globally. I think you've got it really good add a lot and I will add some other comments and how we see COVID right now.

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Yeah, I mean I would say first and from us. Our first quarter is going to be impacted COVID, you saw that in January and early February. If we look at some of the hot spots right now and say Central Southern California is probably the biggest area of impact at the moment. Texas has been an impact, Arizona, those are some of the states in the US. Outside the US, the biggest impact has really been to the UK. There was a significant decline in procedures in the month of January that were actually down an even greater than the levels in terms of procedure deferrals versus April and May of last year. So UK got pretty hard for us, it's not a big market, but one that has been impacted. I think for the most part, the rest of Europe where there has been some spots of impact, nothing of concern from our perspective. We are seeing an impact too in Asia Pacific, Japan is going through the third wave of the virus, but as you heard me in my prepared remarks, we have so many good things going on there. We're generating consistent double-digit growth in the face of even some headwinds from the pandemic, but I would just say that the biggest watch out for us is really the UK and then a lot of our indirect markets that's being impacted the most right now and that would include markets like Spain, Portugal, Russia and South Africa and those are the areas that we're keeping a watch out and where we've seen probably the greatest impact outside the US.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

And Dave. I would say as Carrie mentioned this in our kind of caveats to the the guidance. Look, we're optimistic that obviously the vaccines are having a very positive effect. We believe something like the J&J and additions to other vaccines are going to have a big effect as well, but customers are clearly a little skittish and holding back some reserves relative to these added South African and in UK variance and others that may arise. And so that's why we think this is not going to be a big step up, we think it's going to be linear in the first half. As I've reminded others before. I mean, we don't need to be at herd immunity in our business to start seeing a pickup. We just need to have the ICUs not heavily burdened, and that's either combination of people holding reserve bed back or them fully opening up, and we are seeing those beds to begin opening up and that has a direct correlation with neurosurgery and in many cases some of our more invasive procedures on the tissue technology side. But, we're cautiously optimistic. We don't see a significant amount of business tend up. I think the only caveat to that would be Carrie probably on our capital business, which is, is still under 6% of the business, you can add on probably a few points or so of our instruments business. But again when capital budgets free up. I think that's still kind of a question that's beyond just, but it's also with the cash flow looking like for the different institutions.

Dave Turkaly -- JMP Securities -- Analyst

Great thank you for that. Maybe just a quick follow-up for Carrie, obviously great performance on the gross margin and EBITDA side, the 320 bps improvement. I'm just curious how sustainable some of those increases are. I know your long-term targets are still higher, but that's an impressive bump in a tough time. So, and there some of the spending might come back, but just your thoughts on that level given the environment we're in today, and what we should sort of expect moving ahead would be great. Thank you.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Yeah, I would say that as you think about 2021, certainly, our operating expenses are going to trend up. They were obviously very low in 2020 as we responded to COVID. And as I mentioned in my prepared remarks, our fourth quarter operating expenses were still about $12 million, lower than they were last year. So I do you expect to, for OpEx to move us in 2021, just as we get back to more run rate levels. So, but I would say that net-net, if you use the fourth quarter 2019 as a good run rate level. So fourth quarter 2019 still had obviously that worth doing it, but it had Arkis and rebounded in as well and annualize that fourth OpEx spend, it's essentially about $735 million of annual OpEx spend. I think we'll beat that, I don't think you'll see that level of spend in the business in 2021. I think we're obviously playing more smart spending, prioritizing as we've been spending back. So I would say that will be lower than that. I also think that we'll see some gross margin improvement between 2020 in 2021. I think some of the levers that you saw benefiting us in 2021, even though revenue was down 10% is still going to produce some nice gross margin benefit as we move into 2021 and those are things like tissue supply with ACell in there now and supply addressed and as tissue comes back into a growth mode, that will help our gross margins, but continued leaning out of discontinued products will continue to help our gross margin. And don't forget about this is the year that the end of the year we'll move off the TMA agreement with J&J. So, I would expect some gross margin improvement year-over-year as well as the modest EBITDA improvement with OpEx still coming back a little bit higher, but with the gross margin line kind of helping to offset that.

Dave Turkaly -- JMP Securities -- Analyst

Thank you.

Operator

We will now take the next question from Kaila Krum, Truist Securities, please go ahead.

Kaila Krum -- Truist Securities -- Analyst

Hi guys, thanks for taking our questions. So 2021 guidance basically assumes revenue will be flat or in 2019 levels just on a dollar basis, and obviously you guys are swapping up the ortho extremity business for ACell, but they are about equal size businesses. So, I guess can you just help us understand what your assumptions are for the rest of the business this year, and it seems like you guys are considering that COVID will continue to impact things in the first half, which is any more additional detail you could provide would be helpful.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Sure. I will take that that one. Yeah. Thanks, Kaila. I would say that as you think about comparison to 2019, you're right, it's about flat. So, 2019 the organic growth is about 3% to 4% compared to 2019 when you remove the impact of ortho divestiture and add in ACell, remove that it's about as organic growth of 3% to 4%. And if you go back to the remarks that I said when I described our expectations for the year, we talked about a gradual first half recovery which implies that the second half is going to be stronger than the first half. So, we'll be able to give you a bit more color on first half versus second half when we get to April, our Q1 earnings call, which will be giving some guidance around Q2 at that time. I would expect that you should be thinking about a second half stronger than first half in line with the comments of a first half gradual recovery in COVID impacts assuming to be largely behind us in the second half. And, then in terms of just any segment color I would expect that the segments would largely would perform around the same on an organic basis. So, not a lot of difference in the segment performance at the midpoint on an organic basis.

Kaila Krum -- Truist Securities -- Analyst

Okay, that makes that makes a lot of sense. Thanks. Carrie. And then just in terms of new product launches coming this year with CereLink and Aurora. I mean how meaningful can those new products be and how are you thinking about those contributing in the second half. Thank you.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Do you want to take this Glenn.

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Sure. So clearly the biggest impact from the new product launch point of view, as it relates to 2021 is going to be CereLink. It's a global launch. That will be the most meaningful contributor to NPIs in 2021. Aurora is really going to be controlled market release for tumor, probably around the third quarter and then some other areas that we'll be launching in the fourth quarter, but won't contribute a lot to revenues in 2021, that's more of a 2022 and 2023 revenue growth driver for us. Having said that, I think it's important to reflect on the new products we've launched the last few years. So, you think about the service programmable valve enhancements, new sizes, the toolkit we rolled out, additional tips we put on CUSA, our surgical head ramp, there is a lot of new products that were launched before October that we never saw that the ramp and the demand for that and I think you're going to see a bigger contribution coming from those products in 2021. So it's not a new product, we're launching in 2021, it's definitely going to be a contributor to growth. And, then a new product, we are actually launching this year is a lot more shunt that's very specific to the Japan market along with some other products there. So we do have a nice cadence of new products for launching this year coupled with the fact we have other products launched in the last couple of years that will ramp in 2021, and again that's going to be a big part of our growth story for 2021 when we pass the COVID headwinds.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

And I would just add to Glenn's comments that we clearly had that we've addressed the Tissue Technologies supply issue in 2020, but if you think about 2019 we struggled to bring on new customers because we wouldn't have enough I'm going supply, 2020 obviously because COVID that we didn't reach lot of customers. So, I would argue 2021 and 2022 with that one of the larger growth opportunities, is just the ability to expand that base of products, and now let's something interesting and new and the portfolio such as ACell product line that's going to be also a nice driver for us here over the next couple of years.

Kaila Krum -- Truist Securities -- Analyst

Great, thank you guys.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Thanks.

Operator

We'll now take the next question from Robbie Marcus with JP Morgan. Please go ahead.

Robbie Marcus -- JP Morgan -- Analyst

Great, thanks for taking the questions. So Carrie you guys had a really good free cash flow conversion in fourth quarter here, I noticed that CapEx was probably a bit lower than you normally would have, and I didn't hear guidance for 2021 on for cash flow, so I was just wondering if you could give us thoughts around how that will trend over the coming year.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Sure Robbie. We will start with operating cash flow and then I'll work my way to free cash flow. For 2020 we did just over $200 million in operating cash flow, so a nice robust cash flow even despite, again a COVID-impacted year. I would expect that our operating cash flow will increase into 2021. So, I do expect a modest improvement in operating cash flow. Free cash flow is going to be a little bit lower though than 2020 just because of the fact that CapEx as you mentioned, is going to normalize. So CapEx in 2020 was $39 million and that was the result of us really taking prioritized view of CapEx and really trying to preserve cash as much as we could in 2020 as as we weathered COVID. So I would expect that our capital expenditures for 2021 will float up of probably be in the neighborhood of where 2019 was, the 2019 was around $70 million of CapEx spend. So I think you can peg it around that or maybe a little bit higher just because there is some pent-up demand. So I would say, operating cash flow year-over-year higher, free cash flow a little bit lower just because of the differential in the CapEx spend.

Robbie Marcus -- JP Morgan -- Analyst

Great. And maybe a quick follow-up just staying on free cash flow. The old guidance was for greater than 95% free cash flow conversion. I'm guessing will get an update at the May Analyst Day, but how are you thinking about, we have a couple, I'd say more impactful acquisitions in the short term. How are you thinking about that over just the course of the long-term and where the business sits right now. Thanks.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Yeah, I mean Robbie you're correct in that as we do additional acquisitions that's when we take a little bit of cash to do some integration work that will ultimately benefit and drive our topline faster for us. So, we think it's a good trade off in terms of making those right investments to integrate the businesses. So certainly for from our 2021 perspective, I don't expect to see a free cash flow conversion of 80% like I got in 2020, because again the normalization of some of the numbers including CapEx. But I do think in a normal type of environment where we're steady state, I think those types of cash flow conversions can be there, but in the years where we're going to do an acquisition, and you're going to see us obviously go into that in different to the 60s and maybe be in the 70%-80% range, but I think, and a year where we're in steady state mode, I I think a 90% cash flow conversion is possible.

Robbie Marcus -- JP Morgan -- Analyst

Great I appreciate the thoughts.

Operator

We'll now take the next question from Matthew O'Brien at Piper Sandler. Please go ahead.

Matthew O'Brien -- Piper Sandler -- Analyst

Good morning, thanks for taking the questions. I guess one for Glenn and one for Carrie Gary. Sorry, Pete. Glenn. As far as ACell goes, you know you did a $101 million and 90-95 last year. And now, on a proforma full-year basis we looking for something like 92 this year. And I guess there is some COVID impact, some disruption from integration impact, but why wouldn't that full year proforma number this year just given that all the heavy lifting is kind of behind you, not be really conservative, and then, when do you think the real big synergistic opportunity from a contracting and cross-selling perspective really kicks in? Is it more like 2022 or 2023 or is that even later this year?

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Yeah, no, I just as we think about the guidance for ACell as Carrie had outlined. Obviously, we've got 11 months versus a full year as part of our guidance, we've considered COVID impact that similar to the rest of our tissue business and any time you go through integration like this, you have some typical disruption that takes place with respect to the sales force. And so, that's all factored into our guidance of 83 to 88 for this year. And so, that's how we've looked at our guidance, hopefully we can outperform that number. And to your point around cross selling, when we start to see some of the opportunities materialize, I think it's probably late this year, early 2022. It will take us a couple of quarters to get these products fully rolled out, continuing to cross-sell the entire bag. So I think it's going to take us a couple of quarters to get through that. So we're probably looking at seeing some upside late this year and then moving into 2022

Matthew O'Brien -- Piper Sandler -- Analyst

Okay. Glenn, I mean until like 83 and 88 is really kind of a floor as far as that business grows in your view.

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Yeah. We have uncertainty with respect to how COVID is going to last and we've got to get through the rest of the integration. So I would just say hopefully it is conservative, and that's kind of how we've outlined it.

Matthew O'Brien -- Piper Sandler -- Analyst

Okay, fair enough. And then Carey. I understandQ1, I think I'll let the come into talking about a big ramp throughout the course of the year. but historically you've done 75% of your earnings in the last three quarters and this time around, we are looking for 80%-81% of your earnings in the last three quarters with Q1 being impacted by a lot of things. So what gives you guys the confidence that you can get that level of earnings power in the last three quarters of the year. Can you just give us some levers that you have to pull on in case some of these other issues COVID related or whatnot pop up. Thanks.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Sure. Well, certainly COVID is an impact in Q1 for sure, so that factors into part of our EPS guide for Q1 just given where the revenue ranges, but the other thing I would say is that, as I think about Q1 gross margins, they're going to be a little bit lower than Q1 of 2020 just because that the whole portfolio timing change and you have ortho coming out, which is higher gross margins in the corporate average that comes out for the full three months, yet ACell going in for only two thirds of the quarter. That's going to create a little bit of margin mix there in Q1, that will take margins down a little bit compared to Q1 of 2020. But I do expect that you'll see some lower OpEx spend year-over-year in Q1 because of the fact that again, you have the ortho out which was heavy burden in the the OpEx line and then replacing it with ACell that comes in. But realize that ACell, we're not going to realize all of the synergies there until kind of by the time we.get to the fourth quarter. So part of Q1 also is reflecting this portfolio timing change and the fact that ACell cost synergies will be realized gradually over the course of the year. So that will be part of the build as well as, as I mentioned is that we expect that certainly second half, most of the COVID impact should be behind us at that point. So we would see a heavier contribution of our revenue in the second half versus first half.

Operator

Thank you. We will now take the next question from Matt Taylor, UBS. Please go ahead.

Matt Taylor -- UBS -- Analyst

Hai. Thank you for taking the question. Yes. So the first one I wanted to ask was just a follow-up on ACell, you've made a number of comments on the integration here, I just wanted to know, now you products in house [Indecipherable] positively or negatively. And have we thought about the outlook for longer-term and in different material way given some of these opportunities for synergies.

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Yeah. I would just say we haven't really seen any surprises. I think the good news is we've got the commercial integration well under way. And so, from my perspective, we've been impressed with the product portfolio that came over, it's what we thought it was. We've added a number of ACell specialists that are focused in the wound reconstruction space that would be around the MicroMatrix powder and the Sitel products. And so I think the specialization that they bring, the team is really high-caliber team that we bringing over, the product portfolio is what we thought it was. So really no surprises. I would say, and we're really happy. We're getting great feedback from customers are ready. So we feel really good about it.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

I might do add to it would be the fact that they did do a lot of contracting and so I think that's going to be a nice addition in what we do with our products. And the second part would be, as I mentioned in some of the comments before we're with on the scientific side, I think in their last few years there wasn't a significant focus on new derivative products for a lot of reasons. And with the leadership team we have on the R&D side, clinical, we clearly think there is some opportunities with other derivative products that aren't significant to bring out to the market. So stay tuned on that as well.

Matt Taylor -- UBS -- Analyst

Okay. Okay, great. And then I have one follow-up on the capital. I know you've been talking about in the ongoing capital pressure. It's not too surprising. I was wondering if you could characterize that anymore precisely in terms of the trends that you've seen overtime and how our hospital starting to open up there, the wallets and now that kind of a light at the end of the tunnel, how would you predict that that's going to progress over the next couple of quarters.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Carrie do you want to take a shot at it and Glenn and I can add any color after you comment.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Yeah, I mean, and again I would say that we've seen sequential improvement in capital as we've gone so is they think about Q3 to Q4, capital that was about a 40% sequential improvement and our capital sales that really nice, but still still capital was still about 80% down year-over-year in the fourth quarter. So it's certainly still lag. It's all of the portfolio was only down 1.5% in Q4 and capital is down 18%, it's still obviously quite a lag in the recovery piece. And so we think it's going to take some time. We are encouraged by the discussions we're having, the pipeline remains really strong. We have brought to the table different options to start those conversations, back up financing options, rent-to-own type of models and things like that to get those discussions going. I would say in the smaller capital, I mean I don't think of us is very large capital. I mean, our largest price of a capital you're talking about a couple of hundred thousand. And then we have smaller capital units like Mayfield or our dual lighting headset. Those the smaller pieces of capital are responding better, are coming back a little bit stronger and even our instruments business that can be capital like was only 2% down in the fourth quarter. So the good news is some of the smaller capital pieces are coming back. It's the larger ones that will continue to expect that they lag, but it's not a competitive issue. It's more of just when the budget, what kind of free up. So we're still encouraged by the discussions we're having that we think that will continue to see some capital sales of just continue to be a little bit lighter than the rest of the portfolio at this point.

Matt Taylor -- UBS -- Analyst

Okay, great, thanks.

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

I think I would just add is, we've talked about in the past, it's only 6% to 7% of our revenues. So it's not a big part of our business and the the bright silver lining, here is the funnel is really strong with our capital business, and when it does come back, we actually feel like we'll turn the corner pretty quickly, but it's probably going to be in the second half of this year.

Matt Taylor -- UBS -- Analyst

Thanks so much.

Operator

We'll now take the next question from Shagun Singh, Wells Fargo. Please go ahead.

Shagun Singh -- Wells Fargo -- Analyst

Thank you so much for taking the questions. A couple of on guidance, what have you assumed for backlog in your 2021 guidance? By our estimate, it could be about 9% of sales. And then also what are you assuming for normalizing regen supply coming back, are you in the range of [Technical Issues] $30 million. I think you have delegated 100 or 200 basis points of 2019 sales, are you expecting all of that to dial in, is that in your guidance. And then also what are you assuming in your guidance for Arcus and Rebound growth contribution?

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Carrie?

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Yeah, I would say that overall whether or not we have backlog. I think it's going to be highly dependent on just the course of COVID here. We are assuming a gradual recovery in the first half. So I would say that we don't see a big bolus impact of pent-up demand, a big bubble coming through, I think it's going to be a slow and steady gradual improvement over the course of the first half with an expectation that largely COVID is behind us in the second half. So I don't have a calculation for backlog to provide you that says this is what we've assumed in our numbers. Certainly. I hope there is a little bit of backlog help in 2021, but again at this point, we're seeing the kind of slow and steady improvement over the course of the first half and I don't have the specific breakdowns of Arcus and Rebound at this point. I think Rebound, we do have some contribution of Rebound and Arcus in our 2021 numbers. I still think the larger impact certainly for Rebound of the two is going to be a larger opportunity for us in 2022 and beyond.

Shagun Singh -- Wells Fargo -- Analyst

I got it and what about the demand supply? do you expect all of a during included in your guidance.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

I am sorry I can't hear what you're seeing there and what kind of supply?

Shagun Singh -- Wells Fargo -- Analyst

So given the normalized regen supply, I think the impact of that was the about 100 to 200 basis points

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Oh yeah, the regenerative tissue. Yeah, yeah. Shagun. Yeah, I mean at this point, I would say it's certainly our expectations is that the supply issues have been addressed, and that we are at a point where we can meet any of unconstrained demand as the business recovers. So as I think through the opportunities in 2021. I would assume that Tissue Technologies will be contributing very similar to what we expect for CSS as I mentioned before in one of the questions that somebody asked. I don't expect to be a big differences in the segment performance at this point as I look at the year. So I think tissue technology will be a equal contributor to our growth, goes back to in 2021 and certainly as I think about our gross margin story year-over-year between 2020 and 2021 that benefit of Tissue Technologies and in restoration of the regenerative tissue supply certainly will help my gross margins year-over-year as well.

Shagun Singh -- Wells Fargo -- Analyst

Thank you so much. I will leave with this.

Operator

We will have the next question from Raj Dahi of Jefferies. Please go ahead.

Antony -- Jefferies -- Analyst

Hi, This is Anthony for Raj. I hope everyone is doing well, my question is on margin progression, specifically adjusted margin progression. And so the company ends last fiscal year at 2044, but it has ortho in there and it does not have ACell, some sort of look into the 1Q adjusted EBITDA margin sort of blended number and then it looks like that settles out in the 25% range. So want to make sure that we're thinking about that correctly. And then when we think about the bridge from 25% to the 28 to 30% % range, so how do we think about that in terms of progression. It seems that you can actually get there faster now with the mix meaning that ACell has a higher margin than ortho. So how do we think about margin progression from where we are today to the 28% to 30% range. And I will have one quick follow.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Yeah, I think you're thinking about that really in line with what I would say as well. I think where we finished in 2020 we'll see a little bit of EBITDA margin improvement in 2021. And just a couple of factors as you think about that. In 2020-2021 obviously, my expectation is, we'll still be able to deliver some nice gross margin improvement year-over-year, that's going to be moderated backed by our operating expenditures coming back up and coming from a pretty low year 2020 gradually moving up, but net-net, I think we'll still be able to deliver a little bit of EBITDA margin improvement year-over-year and I think you pegged it right in that 25% type of range, and, but remember what I want to draw you back to that one of the slides that Glenn had in his deck and we've shown this slide before, when we announced the ACell acquisition where we did a proforma look back at 2019 and said if you took 2019 you took ortho out and we added ACell, in the first year the impact EBITDA margins would be about neutral. And so, I still think we can tweak out to margin improvement between 2020 and 2021 with a sell-in. But the real path is going to be into the next year in 2020 when you realize the full synergies of ACell, and you've got ortho out and that's swap there will really show a nice benefit in 2022. So, I think we'll make some really nice inroads in 2022 along our path to get to 28% EBITDA margin.

Antony -- Jefferies -- Analyst

The fault there would be, I guess you mentioned synergies. And so I guess to quantify the synergies, I mean on the cost side, specifically, is there a number out there we should be thinking about. And then when we think about synergies and in cross-selling. I'm just wondering if ACell is it all complementary to the nerve repair channel you spoke about last quarter, are those still going to be two separate and dedicated selling efforts. Thanks again.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Yeah, I'll talk about the the synergies of ACell and maybe ask Glenn to talk a little bit about your second question on there. The ACell synergies you can go back to their 2019.

Operator

Public statements and they had about $80 million of operating expenditures in their business, that was $100 million of revenue. So, essentially the business was at breakeven. So our opportunity is to bring that revenue into Integra and to really synergize and we certainly think we have a lot of opportunity because of the same call points and we think that there is some nice synergies on the infrastructure side there. So, as I think about that I think are our goal is to get about 40% of that OpEx out by the end of the year. And so, there is some nice synergies there. As I mentioned, is I think about full run rate realization of those synergies going into 2022, and then Glenn, you want to tackle the neuro question.

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Yeah. if you think if you look at the ACell portfolio, it really impacts the wound reconstruction business and the surgical reconstruction business and those channels. Now keep in mind we have nerve being sold by the wound reconstruction team today, but we have a specialist group that focuses on it. So I don't see a lot of synergies per se, as it relates to the nerve business.

Antony -- Jefferies -- Analyst

That's helpful, thanks.

Operator

We'll now take the next question from Jayson Bedford at Raymond James, please go ahead.

Jayson Bedford -- Raymond James -- Analyst

Hi, good morning. Just a couple of modeling questions to keep the discussion moving here. In 2020 revenue what was the incremental revenue contribution from the increase in tissue supply and then move from distributor to direct

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

So the tissue business was not the business that was moved it was the general surgical business. So I think of that as CUSA excel and other instruments. We haven't specifically quantified how much that is, but it's one of the contributors to Japan driving double-digit growth. And keep in my Japan today to put in the context is a market that's above $60 million of annual revenue.

Jayson Bedford -- Raymond James -- Analyst

I guess, sorry, it was two items that you're helping with the Japan dynamics, but and the other one was just you had your supply on strain in Q2 side in 2019. And I'm just wondering what was the incremental field in 2020.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

It's hard to know, in 2020 because it was a COVID impacted year. Overall, our business was down because of COVID. So how I would look at 2020 is a year that we recalibrated and and put safety stock back into a supply chain that really was below where we wanted to be. So in 2019, it was missed opportunities, so the demand was there, we just didn't have the supply to go and chase that demand. In 2020 while COVID was impacting our overall top line, we took the approach that we're going to have a couple of our factories, continue to build and bring inventory levels up on some of these critical SKUs such that when the recovery happens that we can then take advantage of it. So it's now there is no way I could quantify the impact as overall 2020 we're still down across the board in our businesses because of the COVID.

Jayson Bedford -- Raymond James -- Analyst

Okay. Is there any way to quantify the delta between demand and supply in 2019 or is that just too far back.

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Well what, that's what I think Shagun was getting after in her question, we had talked about that, it probably was a point to two points of growth that cost us by not having the supply in 2019 to meet the demand. So, certainly we missed in opportunity to grow revenue in OTT because of the fact that we didn't have the supply. So we talked about it being about a 1% to 2% points of our growth in 2019 that it cost us.

Operator

It appears there are no further questions at this time. Mr, Beaulieu. I'd like to turn the conference back to you, sir.

Michael Beaulieu -- Director of Investor Relations

Thank you everyone for listening in today and we look forward to updating you up in our next calls and please make sure that you take note of our Investor Day coming up on May 20th. Thanks everyone.

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Thank you. [Operator Closing Remarks]

Duration: 70 minutes

Call participants:

Michael Beaulieu -- Director of Investor Relations

Carrie Anderson -- Executive Vice President & Chief Financial Officer

Glenn G. Coleman -- Executive Vice President & Chief Operating Officer

Peter Arduini -- Integra LifeSciences Corp -- President & Chief Executive Officer

Matt Miksic -- Credit Suisse -- Analyst

Dave Turkaly -- JMP Securities -- Analyst

Kaila Krum -- Truist Securities -- Analyst

Robbie Marcus -- JP Morgan -- Analyst

Matthew O'Brien -- Piper Sandler -- Analyst

Matt Taylor -- UBS -- Analyst

Shagun Singh -- Wells Fargo -- Analyst

Antony -- Jefferies -- Analyst

Jayson Bedford -- Raymond James -- Analyst

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