When investors consider buying a company, they have different goals in mind. Warren Buffett used to look for beaten-down companies that weren't necessarily great businesses, but were worth more than what they were trading for. He called this "cigar-butt investing," equating the small rise in the shares of a beaten-down stock to the last puff of a nearly smoked cigar.

Other investors spend less time calculating valuation and more time imaging how bright the future could be. Usually, these investors focus on young companies that are growing rapidly and hoping to take over an industry or invent a new one. And there are, of course, other methods. One approach that can double your money -- or more -- is to buy shares in companies experiencing temporary setbacks, ones that impatient investors aren't willing to wait out. Here are two such healthcare stocks that could double your money.

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BioMarin Pharmaceutical

BioMarin (NASDAQ:BMRN) had a 2020 to forget. The company develops drugs for rare diseases that have few patients. In the absence of market demand, the competition is less fierce and prices are higher. Not surprisingly, the company's gross margins -- profit after expenses directly related to creating products -- are consistently about 80%, among the highest in the pharmaceutical industry. Although growth has slowed for BioMarin over the past decade, sales still increased by a respectable 14% in 2018 and 2019.

However, this year the company suffered a surprising delay in the clinical trial for Roctavian, its gene therapy drug for hemophilia A. In August, the U.S. Food and Drug Administration (FDA) asked the company to provide at least another year's worth of data before approving the drug (the first year will be complete in November). The stock promptly fell 37% and now sits 44% below its highs from earlier this year.

Despite this surprise, the steep drop in the stock price gives patient investors an opportunity to pick up shares of a company that has historically been well-managed and immune to the onslaught of generic drug substitutions. The stock currently sits at levels it first reached in 2013. While waiting for Roctavian's eventual launch in mid- to late 2022, the company enjoys virtual monopolies in treating rare genetic diseases such as dwarfism and metabolic disorders. While BioMarin has seen a delay in a potential growth driver in treating an additional disease, it's likely Roctavian will be approved eventually, and investors who are patient will be rewarded by seeing the stock return to the levels it enjoyed before the unexpected announcement. 

OPKO Health

OPKO Health (NASDAQ:OPK) entered 2019 with lower sales than in each of the previous three years. This was reflected in the stock price. As the coronavirus began headlining nightly news segments in March, the shares were down more than 90% from highs reached just before the company used nearly $1.5 billion in stock to buy BioReference Laboratories in 2015. It was a curious acquisition, as OPKO, a drug maker with $91 million in revenue, was purchasing a lab company that generated nearly 10 times the acquirer's revenue. Ostensibly, the deal was meant to use the cash-generating lab business to subsidize the cost of drug research and development. But things haven't worked out as planned -- in 2019, the lab business still generated nearly 80% of revenue, with sales of new drugs having barely budged since the acquisition. 

But the coronavirus pandemic is giving OPKO some new opportunities. The diagnostics business, still called BioReference Laboratories, has benefited from the increased need for testing due to worldwide coronavirus cases. In the second quarter of this year, management reported a 33% increase in sales, primarily attributable to COVID-19 testing. Further, the company reported positive net income, something it hasn't done in any full year for at least the past decade. The second quarter was also highlighted by COVID-19 testing agreements with several high-profile clients, such as the National Football League, the National Basketball Association, several college football conferences, and the New York City school system. The company recently reported third-quarter results, and while the stock fell by 16%, testing volume was up 61% over the second quarter. Diagnostics revenue increased 117% over the prior year as well, to $392 million. The company again was able to produce a profit in the quarter.

Although investors weren't happy with the results, the stock remains up more than 130% from where it entered the year. With high-profile agreements to provide testing -- and both tests and cases hitting new records each day -- the company is poised to ride the coronavirus wave to improved financial performance. Even if a vaccine is approved shortly, it might take a year to get it distributed to those who need it. Couple the distribution challenges with questions about the effectiveness of a vaccine -- especially in a place like the U.S. in which only half the people say they will get the vaccine -- and the need for testing may persist for years to come. Despite a checkered past, OPKO Health has the potential to double investors' money unless the coronavirus disappears like magic.

This article represents the opinion of the writer, who may disagree with the “official” recommendation position of a Motley Fool premium advisory service. We’re motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.