Although we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.

What: Alnylam Pharmaceuticals (Nasdaq: ALNY) shares fell 10% today.

So what: Roche Holding AG announced it would end its partnership with Tekmira Pharmaceuticals, dragging Alnylam down in the fray. This move affects research for RNAi therapeutics, a focus for Alnylam.

Now what: In a release today, Alnylam expressed disappointment that Roche was no longer supporting RNAi therapeutics research, but this isn't the end of the world. Alnylam will continue its research, and management believes "we are on the frontier of demonstrating human proof-of-concept for these and other programs." If you're looking for an opportunity to get into Alnylam, today is as good as any.

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