Give me a break!
Granted, the DMC ended the trial early for efficacy reasons. When it's clear that a drug candidate is working better than the comparator, it becomes no longer ethical to continue the trial and keep patients on an inferior treatment.
What was that inferior treatment that odanacatib beat? Placebo. Sugar pills. Nothing. Nada.
The threshold for ending a trial early is higher than it would be to call a drug successful at the end of the trial, so it's safe to assume that odanacatib is considerably better than placebo. But without the data, which hasn't been released yet, there's no way to know how well the drug performed.
If odanacatib would be the first osteoporosis drug on the market, it would be easy to understand investors' enthusiasm. Trial ended early, Food and Drug Administration approval a near certainty; add the future sales to your DCF model, valuation increases.
But odanacatib would enter a very crowded osteoporosis market. GlaxoSmithKline
Example No. 1: Amgen's
Maybe I'm being overly cautious. Perhaps odanacatib, with the convenience of once-weekly dosing and its novel mechanism will end up being a wonder drug that competes well against the established players. I just think investors should bone up on a little more data before penciling in potential sales.
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