1 Pharma That's Failing Forward

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If at first you succeed, but then you don't, throw in the towel. One might be inclined to think that's what Astex Pharmaceuticals (Nasdaq: ASTX  ) is doing. The company announced last week that it is halting development for amuvatinib, a drug intended for treatment of small-cell lung cancer.

Phase 1 clinical trials showed promise for the drug. However, the company's phase 2 study didn't achieve the desired outcomes. Rather than press forward with continued development of amuvatinib, Astex decided to pull the plug.

While the company's shares were hit fairly hard by the bad news, Astex appears to be poised to fail forward -- to ultimately succeed despite temporary failures. Here are three ways I think it will do so.

Squeezing a little more
Astex currently gains most of its revenue from sales of Dacogen. The drug is approved for treatment of myelodysplastic syndromes in the U.S. and 30 other countries. However, it is not yet approved in Europe or Japan.

Astex should be able to squeeze more revenue from Dacogen by gaining European approval. That approval appears to be forthcoming.

Janssen, a unit of Johnson & Johnson (NYSE: JNJ  ) , holds rights for marketing Dacogen outside of North America. In July, Janssen announced that the key evaluating committee in Europe gave a positive recommendation for use of Dacogen in treating acute myeloid leukemia. A decision from the European Commission is expected soon.

Approval in Europe for Dacogen would easily move Astex past the stigma of failure from its discontinuation of amuvatinib.

Shocking developments
The company hopes to benefit from another drug in its pipeline, AT13387. This drug is a small molecule inhibitor of Hsp90, sometimes referred to as the "Heat Shock" protein. AT13387 could potentially be used in treating several types of cancers.

Astex is completing a phase 1 study of the drug in treating patients with advanced refractory tumors. A phase 2 study in patients with refractory gastrointestinal stromal tumors has been initiated, as well as phase 1 and 2 trials for use of AT13387 in treating prostate cancer.

Of course, AT13387 could suffer the same fate as amuvatinib did. On the other hand, successful trials could lead to a new market for the company.

Howdy, partners
Astex smartly partners with multiple larger pharmaceutical organizations. Johnson & Johnson, through its Janssen unit, not only sells Dacogen outside of North America, but also bought a license to compounds that could come from Astex's Fibroblast Growth Factor Receptor inhibitor program.

Novartis (NYSE: NVS  ) secured the option to develop and commercialize Astex's AT7519, a drug targeted for treatment of multiple myeloma. The company also collaborated with Astex on LEE011, another potential cancer drug.

AstraZeneca (NYSE: AZN  ) is another partner. The large pharmaceutical company initiated phase 1 studies last year for the AZD5363 cancer drug that was part of a joint drug discovery program between the two companies.

Astex also works with GlaxoSmithKline (NYSE: GSK  ) . Under their collaboration agreement, Astex uses its Pyramid platform to develop candidate drugs selected from various therapeutic areas identified by GSK.

The net effect of these partnerships is to cushion the impact to Astex that can come from an isolated failure like that experienced with amuvatinib. These alliances also help the company gain financial benefits more quickly from its pipeline successes.

Failing forward
Astex should be positioned relatively well to move forward even with the amuvatinib stumble. Investors might consider taking advantage of the current stock decline in advance of a potential European approval of Dacogen.

Astute investors might also want to move forward by taking advantage of Wall Street's failures. To be specific, there are several promising stocks that aren't receiving their deserved attention from the financial gurus. Learn about these investing ideas in The Motley Fool's special report: "Middle-Class Millionaire-Makers: 3 Stocks Wall Street's Too Rich to Notice." Get your free copy by clicking here now!

Fool contributor Keith Speights owns no shares in the stocks mentioned above. The Motley Fool owns shares of Johnson & Johnson. Motley Fool newsletter services have recommended buying shares of and creating a diagonal call position in Johnson & Johnson. The Motley Fool has a disclosure policy. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. Try any of our Foolish newsletter services free for 30 days.

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Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

  • Report this Comment On September 25, 2012, at 3:54 PM, alvojiggy wrote:

    Failing forward means to fail as you're moving forward. The title does not seem to be a reflection of the article's sentiment.

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