In the following video, Motley Fool health care bureau chief Brenton Flynn highlights 2012 as a big year for the four biggest biotechs, but the biggest of the four, Amgen (NASDAQ:AMGN), tends to get lost in the mix. He shows us some of the biggest trends in the company's portfolio and pipeline that may be holding that multiple down at the moment. He also discusses information from the company's presentation at the JPMorgan conference this week about its pipeline that may be a needle-mover for the company's multiple back upwards.

Brenton Flynn has no position in any stocks mentioned. The Motley Fool recommends Gilead Sciences. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.