Researchers Select Eli Lilly's Drugs for Detection and Prevention of Alzheimer's Disease

Researchers from Brigham and Women's Hospital have selected Eli Lilly's (NYSE: LLY  ) solanezumab as the first drug to be tested in the previously announced Anti-amyloid Treatment in Asymptomatic Alzheimer's disease, also known as A4, prevention clinical trial.

Solanezumab is a monoclonal antibody that binds to amyloid beta, a protein which aggregates in the brain, forming plaques, a hallmark of Alzheimer's disease. The drug failed its phase 3 trials last year, but showed promise in patients with mild Alzheimer's disease. Eli Lilly recently announced plans to study solanezumab in that specific population.

The National Institutes of Health, and the private sector, will fund the three-year A4 trial that will enroll 1,000 patients ages 70 to 85. Patients will be enrolled in the trial before they show clinical symptoms of Alzheimer's disease, but will have evidence of the abnormal amyloid protein building up in the brain detected on PET scans using Lilly's Amyvid.

Researchers hope that treating patients before they show symptoms will slow cognitive decline, potentially preventing Alzheimer's disease from forming.


Read/Post Comments (0) | Recommend This Article (0)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

Be the first one to comment on this article.

DocumentId: 2204851, ~/Articles/ArticleHandler.aspx, 7/22/2014 6:31:10 PM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...


Advertisement