A Cholesterol-Treatment Contender Partners Up

Watch stocks you care about

The single, easiest way to keep track of all the stocks that matter...

Your own personalized stock watchlist!

It's a 100% FREE Motley Fool service...

Click Here Now

The Medicines Company (NASDAQ: MDCO  ) wants in on Alnylam's (NASDAQ: ALNY  ) early-stage cholesterol treatment ALN-PCS. A new deal requires Medicines Company to make an initial $25 million payment followed by $180 in potential milestones, and double-digit global royalties upon release.

ALN-PCS belongs to the rising class of PCSK9 inhibitors hoping to find a place in the statin-dominated market. Other contenders include late-stage projects from Amgen (NASDAQ: AMGN  ) and the partnership of Sanofi (NYSE: SNY  ) and Regeneron (NASDAQ: REGN  ) . Will Alnylam's drug secure a place in this crowding market?

Same end, different means
PCSK9 inhibitors block a protein that would lead to an abundance of LDL, or "bad" cholesterol, if left unchecked. Amgen's AMG 145 and Sanofi-Regeneron's REGN727 stop the existing protein from doing its damage. Alnylam's drug stops things at the gene that would produce those proteins.

As I've written before, PCSK9 drugs won't dominate high-cholesterol treatments because statins remain well tolerated and offer oral dosage at a low price. But Alnylam hopes their approach will better treat patients who don't respond well to statins.

Early data on the intravenous form of ALN-PCS seem promising. Alnylam presented phase 1 data last year showing the drug reduced LDL levels up to 50% on its own. A subcutaneous injection is in preclinical trials.

The dealmakers
The terms of the new agreement mean that Medicines Company will take over both versions of ALN-PCS when they hit the phase 2 stage. The company has three products approved in the U.S., but the majority of its revenues come from the anticoagulant Angiomax, which had net sales of $360.5 million in the first nine months of last year.

Alnylam is a development-stage company. Its pipeline features projects using technologies based on RNA interface, or RNAi. The treatments include a wide range of conditions that include hemophilia and liver cancers.  

Foolish final thoughts
If it makes it to market, Alnylam's medication will arrive far later than its competitors. Sanofi hopes to push REGN727 to approval in 2015 after the phase 3 initiated last year. Amgen's on the verge of launching the final trials for AMG 145.

But if Alnylam shows a vast efficacy improvement in statin-resistant patients, it could still get a place. I want to wait for mid- and late-stage data to better evaluate ALN-PCS's potential.

While you can certainly make huge gains in biotech and pharmaceuticals, the best investing approach is to choose great companies and stick with them for the long term. In our free report "3 Stocks That Will Help You Retire Rich," we name stocks that could help you build long-term wealth and retire well, along with some winning wealth-building strategies that every investor should be aware of. Click here now to keep reading.

Read/Post Comments (0) | Recommend This Article (1)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

Be the first one to comment on this article.

Compare Brokers

Fool Disclosure

Sponsored Links

Leaked: Apple's Next Smart Device
(Warning, it may shock you)
The secret is out... experts are predicting 458 million of these types of devices will be sold per year. 1 hyper-growth company stands to rake in maximum profit - and it's NOT Apple. Show me Apple's new smart gizmo!

DocumentId: 2234788, ~/Articles/ArticleHandler.aspx, 9/24/2016 7:04:40 PM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...

Today's Market

updated 21 hours ago Sponsored by:
DOW 18,261.45 -131.01 -0.71%
S&P 500 2,164.69 -12.49 -0.57%
NASD 5,305.75 -33.78 -0.63%

Create My Watchlist

Go to My Watchlist

You don't seem to be following any stocks yet!

Better investing starts with a watchlist. Now you can create a personalized watchlist and get immediate access to the personalized information you need to make successful investing decisions.

Data delayed up to 5 minutes

Related Tickers

9/23/2016 4:00 PM
ALNY $75.57 Down -1.52 -1.97%
Alnylam Pharmaceut… CAPS Rating: ****
AMGN $174.80 Down -0.82 -0.47%
Amgen CAPS Rating: ****
MDCO $40.45 Down -1.05 -2.53%
The Medicines Comp… CAPS Rating: ***
REGN $410.39 Up +2.38 +0.58%
Regeneron Pharmace… CAPS Rating: ****
SNY $38.35 Down -0.22 -0.57%
Sanofi CAPS Rating: *****