Amarin Corporation Plc's Rocky Road

Amarin (NASDAQ: AMRN  ) has been a roller coaster of a stock since the launch of its fish oil drug Vascepa. The drug competes with GlaxoSmithKline's fish oil Lovaza, but while Glaxo's drug is often used off label in patients with moderately high triglyceride levels, Amarin hasn't made much in roads into that population.

To get the drug approved for the expanded indication, the biotech signed a special protocol assessment with the Food and Drug Administration, agreeing to run an efficacy study with a surrogate endpoint -- lowering triglyceride levels -- and to substantially enroll an outcomes study measuring cardiac events, such as heart attacks and strokes.

Despite Amarin living up to its end of the bargain -- Vascepa looked even better that GlaxoSmithKline's Lovaza in terms of triglyceride and cholesterol levels -- the FDA decided it really wanted to see the outcomes data, citing data from trials testing Merck's  (NYSE: MRK  )  Cordaptive and AbbVie's Tricor, triglyceride-lowering drugs that work under a different mechanism of action. Both Merck's and AbbVie's drugs lowered triglyceride levels, but failed to improve outcomes.

In the video that follows, Max Macaluso, the Fool's health care bureau chief, and Fool contributor Brian Orelli discuss the biotech's latest predicament.

A company set up for a solid 2014
The Motley Fool's chief investment officer has selected his No. 1 stock for 2014, and it's one of those stocks that could make you rich. You can find out which stock it is in the special free report "The Motley Fool's Top Stock for 2014." Just click here to access the report and find out the name of this under-the-radar company.


Read/Post Comments (1) | Recommend This Article (3)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

  • Report this Comment On February 14, 2014, at 4:30 PM, Bidmark wrote:

    I think of a roller coaster as something that goes up and down. This stock has pretty much been downhill all the way since it's approval in 2012!

Add your comment.

DocumentId: 2840241, ~/Articles/ArticleHandler.aspx, 7/22/2014 4:16:49 AM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...


Advertisement