In this edition of The Motley Fool's "Ask a Fool" series, Motley Fool analysts Jason Moser and Brendan Mathews take a question from a reader who asks, "I believe marijuana is going to made legal in most states. Is the Motley Fool looking at any of these stocks?"

According to Brendan, there are no large, reputable, publicly traded companies that will directly benefit from the recent reforms in marijuana laws made by Colorado and Washington. Of course, this is a well-publicized issue, and there is no shortage of penny stock promoters have surfaced to capitalize on the hype (and take advantage of individual investors).

Unfortunately, a large number of penny stocks and micro-cap stocks tend to work out badly for investors. Many of them have limited business operations, and their "potential" is just hype generated by unscrupulous promoters. Thus, Brendan and Jason suggest treading with caution -- or bet yet, avoid investing in any marijuana-related penny stocks. Investing in penny stocks (whether related to marijuana or not) is the most sure-fire way to lose money in the market.

Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.