Why Neuralstem Inc. Shares Soared

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What: Shares of Neuralstem (NYSEMKT: CUR  )  a clinical-stage biopharmaceutical company fighting central nervous system disorders with neural stem-cell-based therapies -- spiked higher by as much as 15% after announcing intriguing study results for NSI-566 stem cells and their ability to improve poststroke symptoms in rats.

So what: According to Neuralstem's press release of study results that were also published in peer-reviewed journal, PLOS ONE, ischemic-stroke rats that were transplanted with Neuralstem's experimental NSI-566 cells into their brain "experienced functional improvement," and that the "grafts both survived and differentiated into neurons." The findings also appeared to demonstrate the dosing played an important role in functional improvement, with higher doses yielding better results. Neuralstem notes that there was a statistically significant difference in motor skills and neurological test improvement for rats that received 10,000 cells/ul to 20,000 cells/ul compared to rats that received 5,000 cells/ul.

Now what: As per the norm we have plenty of preclinical and early stage excitement surrounding stem-cell therapies, but many have failed to translate into late-stage success stories be it for safety, efficacy, or simply overbearing government regulations into stem-cell research. Smaller studies like this involving rats is encouraging, but it in no way guarantees success when transferring over the human trials. As I've said previously with Neuralstem, I'd much rather wait for later-stage concrete trial data before getting in an uproar about another stem-cell-based biopharmaceutical company. With that being said, I'll glad monitor it from the sidelines.

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  • Report this Comment On March 31, 2014, at 4:14 PM, biubbamoo wrote:

    I just want to point out that Neuralstem is currently underway with a Phase I/II Trial for stroke using the NSI-566 stem cells in China. The trial is anticipated to be completed at the end of 2015.

  • Report this Comment On March 31, 2014, at 4:35 PM, randyaivazis wrote:

    Sean may I suggest you reading the 10K on Neuralstem. This company has so much going for it in the ALS and Depression.Staying on the sidelines well good luck with that. CUR Known as Neuralstem is my largest stock investment. Great results so far.Again read the SEC Filing 10k oN NEURALSTEM

  • Report this Comment On April 07, 2014, at 5:01 PM, LouisTewl wrote:

    Anybody have an opinion on Benitec (BNIKF) - I got out after it doubled just before a $31M equity raise, but am still watching. It's RNAi with defended-in-court patents.

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