Track the companies that matter to you. It's FREE! Click one of these fan favorites to get started: Apple; Google; Ford.



Why Agios Pharmaceuticals Inc. Shares Spiked Higher

Don't let it get away!

Keep track of the stocks that matter to you.

Help yourself with the Fool's FREE and easy new watchlist service today.

Although we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.

What: Shares of Agios Pharmaceuticals (NASDAQ: AGIO  ) , a clinical-stage biopharmaceutical company developing cancer therapies, vaulted higher by as much as 27% after the company on Sunday released initial data on its phase 1 study of AG-221, an oral inhibitor of IDH2 mutations, in patients with hematological malignancies (i.e., blood cancers).

So what: According to its press release, Agios' preliminary data for AG-221 demonstrated that the drug was well-tolerated and safe. More importantly, though not the initial goal of its phase 1 study, AG-221 demonstrated promising clinical activity, including complete clinical remissions, even at the lowest-tested dose. Overall, six of seven evaluable patients had an objective response, with three complete responses and two complete remissions with incomplete platelet recovery, and one patient with a partial response.

Now what: I know this is an early stage study that hasn't even had a maximum tolerated dose established yet, and shareholders should really keep this in mind while reviewing the press release so as not to allow their emotions to get the best of them, but WOW -- three complete responses out of seven evaluable patients is incredible! Obviously I'd like to see how well AG-221 translates into a much larger trial as the current sample size is small, and the only true focus of this initial study was safety and tolerability, which look to be met based on its initial data.

This also looks like it could be a nice win for Celgene (NASDAQ: CELG  ) , which is partnered with Agios in the development of AG-221. Celgene hasn't been shy about partnering up with smaller clinical-stage companies, and it appears that, in the early stages at least, this partnership could be paying off. While I would still urge investor caution as these are merely early-stage initial results, I would also waste no time in at least getting Agios added to your watchlist.

Agios shares are skyrocketing today, but even it could struggle to keep up with this top stock in 2014
There's a huge difference between a good stock and a stock that can make you rich. The Motley Fool's chief investment officer has selected his No. 1 stock for 2014, and it's one of those stocks that could make you rich. You can find out which stock it is in the special free report "The Motley Fool's Top Stock for 2014." Just click here to access the report and find out the name of this under-the-radar company.

Read/Post Comments (0) | Recommend This Article (2)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

Be the first one to comment on this article.

Sponsored Links

Leaked: Apple's Next Smart Device
(Warning, it may shock you)
The secret is out... experts are predicting 458 million of these types of devices will be sold per year. 1 hyper-growth company stands to rake in maximum profit - and it's NOT Apple. Show me Apple's new smart gizmo!

DocumentId: 2905609, ~/Articles/ArticleHandler.aspx, 8/28/2015 8:29:12 PM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...

Sean Williams

A Fool since 2010, and a graduate from UC San Diego with a B.A. in Economics, Sean specializes in the healthcare sector and in investment planning topics. You'll usually find him writing about Obamacare, marijuana, developing drugs, diagnostics, and medical devices, Social Security, taxes, or any number of other macroeconomic issues.

Today's Market

updated Moments ago Sponsored by:
DOW 16,643.01 -11.76 -0.07%
S&P 500 1,988.87 1.21 0.06%
NASD 4,828.33 15.62 0.32%

Create My Watchlist

Go to My Watchlist

You don't seem to be following any stocks yet!

Better investing starts with a watchlist. Now you can create a personalized watchlist and get immediate access to the personalized information you need to make successful investing decisions.

Data delayed up to 5 minutes

Related Tickers

8/28/2015 4:00 PM
AGIO $90.69 Up +0.67 +0.74%
CELG $124.04 Up +1.00 +0.81%
Celgene CAPS Rating: *****