Although we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.

What: Shares of GW Pharmaceuticals (NASDAQ:GWPH), a biopharmaceutical company engaged in the discovery of cannabinoids and effecting biologic pathway change through use of those cannabinoids, surged as much as 17% after announcing physician reports on investigational treatment-resistant epilepsy drug epidiolex in children and young adults.

So what: According to its early morning press release, of the 27 children and young adults evaluated by physicians in its study, which included nine cases of Dravet syndrome, patients that did respond to epidiolex demonstrated a high propensity to have a 50% or greater reduction in seizures, with 15% of patients going the entire 12-week treatment course seizure-free. As noted, mean overall reduction in seizure frequency from baseline was 44%, with 41% of all patients obtaining at least a 70% reduction in seizure frequency. Utilizing additional safety data from another study which allowed a look at a patient pool of 62 children and young adults, 80% of all adverse events were considered mild-to-moderate with no patient withdrawals due to adverse events. GW anticipates moving its epidiolex development program into phase 2/3 by the latter half of this year.

Now what: This is positive news for GW Pharmaceuticals and would appear to signal that epidiolex is, to some degree, effective at reducing seizure frequency, especially in Dravet syndrome patients where the average seizure reduction percentages were even higher. But as I've noted in the past, GW's potential on paper and its current valuation have never aligned. Sativex, its multiple sclerosis-related spasticity treatment has sold poorly throughout much of Europe, and the company could face backlash from physicians who are simply unwilling to prescribe something derived from the cannabis plant. Marijuana stocks are certainly all the rage, and none has more potential than GW Pharmaceuticals; I will give it that. However, at a valuation of nearly $1.6 billion, with zero guarantees that it'll infiltrate the highly profitable U.S. markets, I'd suggest passing on GW here.

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Sean Williams has no material interest in any companies mentioned in this article. You can follow him on CAPS under the screen name TMFUltraLong, track every pick he makes under the screen name TrackUltraLong, and check him out on Twitter, where he goes by the handle @TMFUltraLong.

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