Track the companies that matter to you. It's FREE! Click one of these fan favorites to get started: Apple; Google; Ford.



2 Top Catalysts This Week: AstraZeneca and Merrimack

Let's take a look at next week's top health care and biotech catalysts. Keep an eye out AstraZeneca (NYSE: AZN  ) and Merrimack Pharmaceuticals (NASDAQ: MACK  ) .    

AstraZeneca's ovarian cancer drug set to be reviewed next week
AstraZeneca decided to repeatedly rebuff Pfizer's acquisition overtures largely because it has confidence in its clinical pipeline. Next week will be the first test of the company's faith, as its platinum-sensitive relapsed ovarian cancer with germline BRCA mutation drug dubbed "olaparib" is set to be reviewed by the Food and Drug Administration on June 25.

Per usual, we should see the all-important briefing documents released two days prior to the Advisory Panel. The drug's PDUFA target action date is presently scheduled for Oct. 3.   

What's key to understand is that olaparib has had a rocky developmental history, with AstraZeneca even shuttering its clinical trials at one point and taking a $285 million charge in the process. After restarting its clinical program by launching a late-stage trial last year, the company subsequently submitted a New Drug Application, or NDA, to the FDA based on the drug's midstage results. AstraZeneca has also launched a late-stage study for olaparib as a potential treatment for BRCAm breast cancer. 

Given that olaparib has blockbuster potential if approved for multiple indications, it is certainly worth keeping tabs on this Advisory Committee meeting next week. Moreover, olaparib is expected to be an important driver of top line growth going forward, as the company continues to lose patent protection for former top-selling drugs like Nexium. In sum, this could be the start of AstraZeneca's recovery from the so-called patent cliff that cost the company a reported $2.2 billion last year alone.  

Merrimack Pharmaceuticals will discuss late-stage study for pancreatic cancer drug
Merrimack Pharmaceuticals will give an oral presentation at the
European Society for Medical Oncology World Congress on Gastrointestinal Cancer on June 25, where it will reveal further details of its successful late-stage study for MM-398 as a second-line treatment for pancreatic cancer. 

MM-398 was previously reported to increased survival by 1.9 months when used in combination with 5-fluorouracil and leucovorin, which was statistically significant compared to the control arm of 5-FU and leucovorin. But MM-398 did not confer a significant clinical benefit in terms of increased survival when used as a monotherapy. 

Shares of this small-cap biotech have shot up close to 50% since announcing these top line results and investors are eagerly awaiting more news regarding a possible NDA filing with the FDA later this year. 

Merrimack is slated to provide an update on the drug's safety and efficacy at this upcoming meeting. That being said, investors should keep an ear open for details regarding the company's plans for a regulatory filing and the drug's estimated market opportunity. To date, we still don't know much about how Merrimack envisions MM-398 to fit into the current landscape of pancreatic cancer treatments or its commercial potential.

And with Merrimack losing its partner Sanofi last week for the development of MM-121, the company's outlook would appear to depend even more heavily upon MM-398 going forward. Merrimack will hold a conference call at 8 a.m. E.T. on June 26 to discuss the data being presented at the conference.  

Leaked: This coming blockbuster will make every biotech jealous
The best biotech investors consistently reap gigantic profits by recognizing true potential earlier and more accurately than anyone else. Let me cut right to the chase. There is a product in development that will revolutionize not how we treat a common chronic illness, but potentially the entire health industry. Analysts are already licking their chops at the sales potential. In order to outsmart Wall Street and realize multi-bagger returns you will need The Motley Fool’s new free report on the dream-team responsible for this game-changing blockbuster. CLICK HERE NOW.

Read/Post Comments (0) | Recommend This Article (1)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

Be the first one to comment on this article.

Sponsored Links

Leaked: Apple's Next Smart Device
(Warning, it may shock you)
The secret is out... experts are predicting 458 million of these types of devices will be sold per year. 1 hyper-growth company stands to rake in maximum profit - and it's NOT Apple. Show me Apple's new smart gizmo!

DocumentId: 3001485, ~/Articles/ArticleHandler.aspx, 8/27/2015 8:37:19 PM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...

George Budwell

George Budwell has been writing about healthcare and biotechnology companies at the Motley Fool since 2013. His primary interests are novel small molecule drugs, next generation vaccines, and cell therapies.

Today's Market

updated Moments ago Sponsored by:
DOW 16,654.77 369.26 2.27%
S&P 500 1,987.66 47.15 2.43%
NASD 4,812.71 115.17 2.45%

Create My Watchlist

Go to My Watchlist

You don't seem to be following any stocks yet!

Better investing starts with a watchlist. Now you can create a personalized watchlist and get immediate access to the personalized information you need to make successful investing decisions.

Data delayed up to 5 minutes

Related Tickers

8/27/2015 4:04 PM
AZN $31.61 Up +0.48 +1.54%
AstraZeneca plc (A… CAPS Rating: ****
MACK $10.43 Up +0.34 +3.37%
Merrimack Pharmace… CAPS Rating: ***