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Biotech Bargains for Your Portfolio

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Everyone is looking for bargains this time of year. That includes pharmaceutical giants looking to pick up some biotechs on the discount rack, and investors trying to get there first.

The easiest way to value a drug company is by looking at its enterprise value. That's simply the market capitalization, minus the company's cash and equivalents, plus its debt. Essentially, that's what it would cost for a pharmaceutical giant to buy the company at the current stock price since the acquirer would get the company's cash and assume its debt.

Companies with low enterprise values are usually that way for a reason and separating the loss-leader black-Friday bargains from the crowd isn't easy, but let's give it shot.

I ran a screen using the following criteria to get us started:

  • Market cap above $125 million to avoid the penny stocks.
  • Enterprise value of less than $600 million.
  • Four or five stars in Motley Fool CAPS -- using community intelligence to get an idea of what other investors think are bargains.

Here's a few that look interesting:

Company

Market Cap
(in millions)

Enterprise Value
(in millions)

CAPS Rating
(out of 5)

Myriad Pharmaceuticals

$127

($32)

*****

Spectrum Pharmaceuticals (Nasdaq: SPPI  )

$228

$85

*****

3SBio (Nasdaq: SSRX  )

$292

$185

****

ViroPharma (Nasdaq: VPHM  )

$603

$451

*****

Exelixis (Nasdaq: EXEL  )

$734

$555

****

Source: Capital IQ, a division of Standard & Poor's, and Motley Fool CAPS.

Free money!?!
That's not a typo. Myraid Pharmaceuticals is trading for less than the cash and short term investments on its books. When the company was spun off from Myriad Genetics earlier this year, the company was seeded with a drug pipeline and enough cash to tide it over for a while.

It's not that investors think its pipeline is completely worthless. Instead, they're valuing the company now based on what Myraid will look like in the future. Without a source of revenue, the company's bound to have a lot less cash in coming years than it has today.

Sure, some larger drug company could come along and offer to purchase the company -- it happened to Facet Biotech with Biogen Idec (Nasdaq: BIIB  ) -- but until investors are certain of that happening, Myraid will stay valued based on its projected future cash levels.

But ... but we have drugs on the market
Spectrum, 3SBio, and ViroPharma all have drugs on the market, but they're being valued like their drugless brethren.

In Spectrum's case, the low valuation is understandable; the company is still losing money, and the two drugs it does have are fairly low sellers -- just $23 million combined so far this year. Spectrum's Zevalin was recently approved as a first-line therapy for lymphoma, so there's potential to increase sales, which would naturally increase its enterprise value.

3SBio sells generic drugs in China. Sure, investing in China can be scary, but ascribing a $185 million value to drugs that sold for $44 million over the last year seems a little low. Sure the drugs are copycats of ones sold in the U.S., but 3SBio still manages gross margins near 92%, and it's been profitable for many years.

ViroPharma has two drugs on the market headed in the opposite direction. Vancocin hasn't been covered by a patent for years, but it's continued to enjoy a monopoly in the U.S., where the Food and Drug Administration has been reluctant to approve generic versions of the antibiotic. Unfortunately, it looks like that's going to change, after an advisory committee recommended approving generic versions of Vancocin.

With a $450 million enterprise value, the lost Vancocin sales are already priced in. Recently approved Cinryze, which treats hereditary angioedema, a rare swelling disease, has a current run rate of about $110 million a year, but management says it has many patients who are working on getting reimbursement completed, so that they can get on the medication.

A well-stocked pipeline
Exelixis is the most expensive of the bunch, and it doesn't have any drugs on the market, but it does have an outstanding pipeline. It's outlicensed five drugs to companies including GlaxoSmithKline (NYSE: GSK  ) and Bristol-Myers Squibb (NYSE: BMY  ) , and it has another eight oncology drugs that are fully or partially owned by the company. If any one of the compounds makes it through the marathon of clinical trials, Exelixis should fetch an enterprise value of a couple of billion dollars.

Before you go shopping
Enterprise values are a good way to determine what a pharmaceutical company would have to pay to purchase a company, but that doesn't mean that they'll come along and buy them. If you're going to invest in these companies, you should plan on holding them long enough for them to increase in value of their own volition.

Think you've found a biotech bargain that's being undervalued by the market? Share it in the comments section below.

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Exelixis and 3SBio are Motley Fool Rule Breakers recommendations. The newsletter is always on the hunt for hot drug stocks and other cutting-edge picks. Click here to see all of our latest discoveries with a free 30-day trial subscription.

Fool contributor Brian Orelli, Ph.D., doesn't own shares of any company mentioned in this article. The Fool owns shares of Exelixis and has a disclosure policy.


Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

  • Report this Comment On November 28, 2009, at 8:13 AM, BIGJIMT wrote:

    Brian, this was an interesting article. So many investors who are married to Biotech stocks, think their stock is a bargain if it is down almost 30% in 45 days.

    But as you know there is a reason for everything.

    Your selections make perfect sense. However, when a

    stock is down almost 30% recently, and there is no serious earnings revenues, no late stage phases with success, and a company chronically is always looking for Money to pay next years expenses, this is by far not a bargain stock. Especially when they receive warning letters from Nasdaq, letters of 'growing concern' from their own accountants, and the future year end earnings report will be below par.

    THIS IS NOT A RED TAG SALE PRESENT, BUT RED FLAGS FOR THE FURTHER REDUCTION IN STOCK PRICE. THROWING MORE MONEY AFTER A BAD CHOICE IS SIMPLY NOT THE WAY TO INVEST. ASTUTE MOTELY READERS KNOW THIS, BUT THERE ARE PLENTY OF FOOLS OUT THERE WHO CAN'T RECOGNIZE A BAD APPLE FROM A GOOD ONE.

    CASE IN POINT, MDRNA INC(MRNA) $.86 CENTS

    TO SHOW YOU MORE EVIDENCE OF HOW FOOLISH SHAREHOLDERS ARE, THIS WAS $20 DOLLARS LATE 2006, JUST THREE YEARS AGO.

    THIS IS NOT A BARGAIN! SIMPLY, A FOOLS STOCK!

  • Report this Comment On November 30, 2009, at 9:11 AM, horatioalger wrote:

    good article. i've been doing a lot of work on MYRX. Having done this for about 20 years, I have been lucky enough to survive with respectable profits. it is stocks like this one that have made me most of my money. it has everything i need. priced for failure, significantly below cash, great management, and no liabilities. this is now just a waiting game. their pipeline is very impressive and not well understood. something will trigger this for a big move. a takeout most likely, positive data or a big partnership. for me this is my early xmas present.

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2/10/2012 4:00 PM
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