What Will You Regret Not Buying in 20 Years?

Feel like crying over missed opportunities? Check out the following returns for some notable stocks over the past two decades:

Company	20-Year Average Annual Return
EMC (NYSE: EMC  )	30%
Qualcomm (Nasdaq: QCOM  )	25%*
UnitedHealth Group (NYSE: UNH  )	26%
Intel (Nasdaq: INTC  )	16%
Altria (NYSE: MO  )	15%
US Bancorp (NYSE: USB  )	14%
Pfizer (NYSE: PFE  )	13%
ExxonMobil	12%
S&P 500	6%

Source: Yahoo! Finance.
*Over the past 18 years.

A $5,000 investment in Intel 20 years ago would be worth almost $100,000 today. The same investment in UnitedHealth would be worth nearly $600,000! Truly, one stock can change everything -- even in a recession.

So why didn't you buy them 20 years ago? (Or even 15 years ago -- it's rarely too late to buy a stock that's still a strong grower.) Why aren't these amazing returns yours? Why isn't your portfolio home to a few millionaire-maker stocks?

What stopped you?
There are many reasons you might not have bought these companies 20 years ago. Maybe you weren't yet awakened to the promise of the stock market. (I know I wasn't.) Maybe you didn't have money to invest, even if you wanted to. But even if you wanted to invest, and had the means to do so, you probably still didn't buy these companies for your portfolio. Why?

Perhaps you didn't expect some of them to keep generating strong returns. With others, though, you may not have seen their promise -- because you weren't imagining a future very different from the present.

You didn't anticipate how a company like EMC would make billions providing storage solutions to companies. You weren't aware of how Qualcomm would prosper by licensing critical technology for cell phones and more. You didn't understand that biotechnology companies would develop exciting new drugs and treatments. You didn't imagine how certain retail chains would prosper by focusing on specific niches, such as electronics.

Many of these companies succeeded in large part because they changed the status quo, breaking the rules about "how things are done" along the way.

And now, when such innovations are apparent to even the dimmest of us, those companies are household names. Their very ubiquity means they won't be maintaining those stratospheric growth rates going forward. They may still serve your portfolio well, but they aren't likely to blow its doors off anymore.

Don't kick yourself
Even though these companies are well past their rule-breaking stage, there are a bunch of small, growing up-and-comers poised to do the same thing. These businesses are breaking the rules, moving first in exciting new arenas, and creating new ways of doing things. Some might even deliver out-of-sight returns for you over the coming 20 years. (I know -- it can take some guts to invest in them. But that can pay off.)

How can you tell the difference between the companies that will deliver out-of-sight returns and companies that will simply sink out of sight? Fool co-founder David Gardner looks for companies that offer "the highest possible returns" -- companies that are top dogs in important and emerging industries and have sustainable advantages, strong past price appreciation, good management, and more.

Take video gaming, for example. The industry has enjoyed explosive growth, up 19% in 2008 and generating $21 billion, though it slipped a little during 2009's recession. Still, many gaming companies have been seeing sales soar. Both Activision Blizzard and Take-Two Interactive have been busy changing the rules of the game -- and setting new standards.

What will you regret not buying today?
Among many other exciting companies, David and his team have found a specialist in surgical robots, a company that runs China's premier search engine, and a business involved in commercial space systems. Each of these contenders has some key traits in common with the powerful performers in the table above.

If you'd like to see what David and his team are spotting today, I invite you to take advantage of a free 30-day trial of our Motley Fool Rule Breakers service. You'll get full access to all past issues and every previous recommendation, many of which are in cutting-edge fields such as biotech, alternative energy, and nanotechnology. Click here to learn more.

Give it some thought. You might want to park a little money in some of "the greatest growth stocks of the next generation."

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This article was originally published on March 4, 2009. It has been updated.

Longtime Fool contributor Selena Maranjian owns shares of Activision Blizzard. Intel, Pfizer, and UnitedHealth Group are Motley Fool Inside Value picks. Take-Two Interactive Software is a Rule Breakers recommendation. Activision Blizzard and UnitedHealth Group are Stock Advisor picks. Motley Fool Options has recommended a synthetic long position on Activision Blizzard and a buy calls position on Intel. The Fool owns shares of Activision Blizzard and UnitedHealth Group. The Motley Fool is Fools writing for Fools.