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Better Buy: Cell Therapeutics or Sequenom?

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Today's match is a battle of the fallen, pitting Cell Therapeutics (Nasdaq: CTIC  ) and its Food-and-Drug-Administration-rejected pixantrone against Sequenom (Nasdaq: SQNM  ) and its employee-mishandled data.

Both have fallen considerably, off about 80% from their more recent highs. That doesn't necessarily make them buys. (Some companies do fall to zero, you know.)

Running out of cash
In Cell Therapeutics' case, the company needs to run an additional trial to get pixantrone approved to treat non-Hodgkin's lymphoma (NHL). That won't be cheap, and the company doesn't have much money in the bank. A special shareholder meeting to increase the share count in order to make a secondary offering has been suspended multiple times. Yesterday, the company sold some shares to a private investor, but it only raised about $4 million. That's hardly going to get the job done.

Even if the company can find more cash -- perhaps by mortgaging itself to the hilt -- there's no guarantee that the drug will pass the clinical trial. If pixantrone does clear that hurdle, the drug could find a home among other drugs that treat NHL -- Biogen Idec (Nasdaq: BIIB  ) and Roche's Rituxan, Cephalon's (Nasdaq: CEPH  ) Treanda, and Spectrum Pharmaceuticals' (Nasdaq: SPPI  ) Zevalin -- especially as a treatment of last resort. But those are a couple of big ifs.

Trying times for a tester
Sequenom has revenue coming in, but it's not turning a profit. Over the first quarter, its cash and short term investments fell by $13.5 million. A pathway to profitability isn't exactly clear-cut.

The company's ability to bring an accurate blood test for Down syndrome to market is equally unclear. Last year, the company seemed to have a test that could accurately read out fetal genetic material from the mother's blood. It turns out that the researchers knew the correct readout of the samples ahead of time, which made interpreting the results rather easy.

The company plans to push forward, validating the test with blinded samples. Will the tests come up accurate? It's fairly hard to handicap. We're talking about a new technology that may or may not be sensitive enough to make an accurate call.

And the victor is…
Between Cell Therapeutics and Sequenom, the winner is Sequenom, simply thanks to its slightly better financial footing. That said, there's no reason you have to buy either. As Tom Gardner pointed out yesterday, there are thousands of companies available for investing. If you're going to take a flier on either of these, make sure it's a very small percentage of your portfolio.

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Fool contributor Brian Orelli, Ph.D., doesn't own shares of any company mentioned in this article. The Fool has a disclosure policy.


Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

  • Report this Comment On July 27, 2010, at 2:59 PM, oracleatdelphi66 wrote:

    This article appears to rely on yesterday's "Fool's" piece on Cell's current cash position. That article presented incorrect data and claimed Cell's debt is more than its cash reserves---wrong again. This article also fails to point that CTI also plans to file for pixantrone approval in the EU come this fall. Dan Eramian, CTI

  • Report this Comment On July 27, 2010, at 3:26 PM, shivy1 wrote:

    They are both terrible companies, the fact you are recommending either is a bad idea. I wouldnt even invest a small percentage because more than likely their fate rests in the hands of the FDA, I have a better chance of playing slots in Vegas.

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