Track the companies that matter to you. It's FREE! Click one of these fan favorites to get started: Apple; Google; Ford.



No Guts, No Glory

Don't let it get away!

Keep track of the stocks that matter to you.

Help yourself with the Fool's FREE and easy new watchlist service today.

Elan's (NYSE: ELN  ) message to partner Transition Therapeutics: It's time to decide whether you want to fish or cut bait.

Transition jumped over the side of the boat with a pile full of cash.

The duo's 2006 deal allowed Transition to continue to pay 30% of the development cost for its Alzheimer's drug ELND005, increase its share to 40%, or relinquish its share in exchange for lower milestone payments and a royalty on future sales.

In August, Elan gave Transition until Dec. 1 to make the decision and then gave it an indefinite extension at the end of November. It looks like the time is up, as Transition announced yesterday that it would take door number three: a royalty agreement.

It should be noted that the press release says the companies "mutually agreed to modify their collaboration agreement," but we know who's in charge here. Elan is a $3.5 billion company with $426 million in cash and short-term investments in the bank. Transition's market cap is so low it doesn't register on many stock screens and only has around $24 million in cash to play with.

Elan learned from the best. You'll recall that Johnson & Johnson (NYSE: JNJ  ) twisted Elan's arm when it needed to renegotiate its partnership, after Biogen Idec (Nasdaq: BIIB  ) convinced a court that one aspect of the J&J-Elan deal allowed Biogen to gain full control of Tysabri, which it markets with Elan.

While Elan looks to be making out well here by gaining full control with lower milestone payments, it's also likely taking on more risk because it'll have to cover the full cost of the phase 3 trials. ELND005 didn't produce a statistically significant change in cognitive and functional measurements in its phase 2 trial. But the drug reduced amyloid-beta protein in the cerebrospinal fluid, which the duo figured was a good sign to bring the drug into phase 3.

That of course assumes that the amyloid-beta protein causes Alzheimer's disease, which is somewhat debatable after Eli Lilly's (NYSE: LLY  ) semagacestat died in phase 3 development. Semagacestat is an inhibitor of a protein that releases amyloid. No amyloid, no amyloid plaques, no Alzheimer's progression -- or so the theory went.

Elan's no-guts-no-glory mantra worked with Tysabri. Biogen and Elan got the multiple sclerosis drug back on the market when things looked bleak, and investors were rewarded handsomely. It remains to be seen whether it'll work for ELND005 or its other Alzheimer drug, bapineuzumab, which Elan and Wyeth -- now Pfizer (NYSE: PFE  ) -- sent into phase 3 trials despite not having phase 2 data in hand.

Interested in keeping track of Elan as it tackles Alzheimer's disease head on? Click here to add it to My Watchlist, which will help you keep track of all our Foolish analysis on Elan.

Fool contributor Brian Orelli, Ph.D., doesn't own shares of any company mentioned in this article. Elan is a Motley Fool Rule Breakers recommendation. Pfizer is a Motley Fool Inside Value pick. Motley Fool Options has recommended a diagonal call position on Johnson & Johnson, which is a Motley Fool Income Investor selection. The Fool and Motley Fool Alpha both own shares of Johnson & Johnson. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Fool has a disclosure policy.

Read/Post Comments (0) | Recommend This Article (4)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

Be the first one to comment on this article.

Compare Brokers

Fool Disclosure

Sponsored Links

Leaked: Apple's Next Smart Device
(Warning, it may shock you)
The secret is out... experts are predicting 458 million of these types of devices will be sold per year. 1 hyper-growth company stands to rake in maximum profit - and it's NOT Apple. Show me Apple's new smart gizmo!

DocumentId: 1412085, ~/Articles/ArticleHandler.aspx, 10/26/2016 11:14:03 AM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...

Today's Market

updated Moments ago Sponsored by:
DOW 18,186.25 16.98 0.09%
S&P 500 2,144.02 0.86 0.04%
NASD 5,263.40 -20.00 -0.38%

Create My Watchlist

Go to My Watchlist

You don't seem to be following any stocks yet!

Better investing starts with a watchlist. Now you can create a personalized watchlist and get immediate access to the personalized information you need to make successful investing decisions.

Data delayed up to 5 minutes

Related Tickers

10/26/2016 10:58 AM
BIIB $298.21 Up +12.21 +4.27%
Biogen CAPS Rating: *****
ELN.DL2 $0.00 Down +0.00 +0.00%
Elan CAPS Rating: ***
JNJ $114.93 Up +0.97 +0.85%
Johnson and Johnso… CAPS Rating: ****
LLY $77.03 Down -0.72 -0.93%
Eli Lilly and Co. CAPS Rating: ***
PFE $32.45 Up +0.17 +0.53%
Pfizer CAPS Rating: ****