The company's phase 3 trial for AEZS-130, its diagnostic test for adult growth hormone deficiency, or AGHD, seems to have been a success. Orally administered AEZS-130 diagnosed patients just as well as a combination of Serono's Geref Diagnostic and Pfizer's
From a patient's perspective, an oral medication usually trumps one that has to be injected because most patients hate needles, but it's less of an issue for a diagnostic test that isn't given daily. The older drugs do have to be administered over 30 minutes, so the oral administration is more convenient for the person giving the test, which might be a competitive advantage.
Unlike a standard diagnostic test that uses a patient's blood to determine their status, AEZS-130 has to be administered internally, so safety becomes just as important as how well the diagnostic correctly diagnoses a patient. Aeterna Zentaris described AEZS-130 as "safe and well tolerated," so we'll just have to assume that it isn't an issue until we see more data.
Aeterna Zentaris plans to submit its marketing application for AEZS-130 fairly soon, so it'll likely beat perifosine to the market, but I still think the cancer drug is the one to watch. Even though Aeterna Zentaris out-licensed the rights to perifosine to Keryx Biopharmaceuticals
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