Just not solid enough, judging by the 20% decline today. With shares up more than 15% from last year, high expectations were built into the price.
The biotech and partner Astellas Pharma tested their kidney cancer drug tivozanib against Nexavar, sold by Onyx Pharmaceuticals
Cancer drugs tend to be tested against placebo rather than head to head against an active comparator. Comparison to placebo makes it easier to prove that the drug works and get it approved, but also makes it harder to compare the new drug to what's already on the market. For instance, you'll often hear that Dendreon's
So kudos to AVEO for having the guts to test the drug against Nexavar; the gamble certainly paid off. Tivozanib delayed progression-free survival, the time it takes for the tumor to start growing again, by 11.9 months compared to 9.1 months for patients taking Nexavar. That's a solid win, especially since the Nexavar group performed better than expected.
The problem is that Nexavar isn't the top-selling kidney cancer drug. That honor belongs to Pfizer's
The take-home message here is that the data is good enough to get tivozanib approved and take much of the kidney cancer market being served by Nexavar. Whether it can push into Sutent's domain without head-to-head data is still up in the air. Going up against a powerhouse like Pfizer with an established drug won't be easy. Fortunately, AVEO signed up a solid partner in Astellas Pharma, which made a major move into the oncology field a few years ago with its purchase of OSI Pharmaceuticals.
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