Warren Buffett's first rule of investing is: "Never lose money." To this, he often adds rule No. 2: "Never forget rule No. 1." Of course, following these rules is easier said than done. But Buffett's done pretty well, so it seems unwise to simply dismiss his advice as the semi-coherent ramblings of a man who's read way too many 10-Ks.

I take those rules to heart in my investment strategy. I try to focus my investment dollars on sustainable, undervalued businesses that I can easily understand. Buffett has made more than $60 billion for himself using that strategy, and he's made even more for his partners and shareholders over the years. Do you really need to assume a lot of risk to make more than $60 billion? My answer, and the answer of my colleagues at Motley Fool Inside Value, is "Heck, no!" If I make only $60 billion, I'll be perfectly satisfied.

People spend a lot of time discussing the companies Buffett buys. But in the spirit of not losing money, it's equally worthwhile to understand the types of businesses that Buffett does not buy in order to steer clear of potential duds. I see five main categories:

1. Businesses that bet the farm
In some industries, companies occasionally have to make critically important decisions. If the company makes the wrong choice, it will be dealt a crippling blow. This is terrible for a shareholder, because even if the company makes the right decision one month, it might fail to do so the next. Although Vonage (NASDAQ:VG) seemed like a great idea for investment dollars a few years back, the market quickly realized that there wasn't much substance to this one-trick pony and lost interest. There's no "three strikes and you're out" policy in this market. One strike, and it's game over -- your money's gone.

2. Businesses dependent on research
It's quite reasonable to believe that research can be a competitive advantage for certain companies. In fact, one reason Genentech (NYSE:DNA) has been so successful is that it has devoted so much to top-notch research and development. Nevertheless, there is a downside to research. Often, innovative companies are required to do research simply to maintain their competitive position. And if the research dries up, the company suffers.

For instance, consider the plight of Electronic Arts (NASDAQ:ERTS). Like all of the major video game companies, EA has had periods of stellar performance and great earnings growth. But in the past five years, EA has been more than unimpressive -- and has significantly lost to the market. Why? Certainly a good part of the reason why the company has been so lackluster is that the company must devote so much of its time and energy to researching the next big game. When innovation dries up a bit, the blockbusters become fewer and farther between -- and rivals like Activision (NASDAQ:ATVI) are given the chance to seize market share.

This is in stark contrast to a company like UnitedHealth (NYSE:UNH), which could develop nothing for a decade and still have a healthy business. While I don't think this is sufficient reason to sell off all your tech or biotech stocks, I can understand why Buffett avoids such investments.

3. Debt-burdened companies
In general, Buffett avoids companies with a lot of debt. This makes sense. During the best of times, large amounts of debt mean that cash that could be put toward growing the business or rewarding shareholders is instead servicing the debt. In a crisis, debt greatly limits a company's options and can sometimes lead to bankruptcy.

A more subtle point is that great businesses throw off piles of cash. Great businesses generally don't need to use huge amounts of debt leverage to achieve an acceptable return for shareholders. So, if a company needs debt to achieve reasonable returns, it's less likely to be a great business. You can see this with Comcast (NASDAQ:CMCSA) and Time Warner Cable (NYSE:TWC). Both have billions of dollars in debt at levels which nearly meet their respective market caps. More importantly, they rely on this debt to build out their productive capacities -- it's a necessity. Now that these companies are in a horrible economic environment, the two must pay back that money while trying to compete in a miserable competitive landscape.

4. Companies with questionable management
Management has incredible power. If executives want to enrich themselves at the expense of shareholders, either directly or by misrepresenting the company's prospects, individual shareholders have almost no hope of stopping them. I strongly recommend avoiding companies where there's even a hint that management lacks integrity. Some clues to look for here include excessively optimistic press releases, overly generous compensation or options grants, and frequently blaming external circumstances for operational shortcomings. WorldCom and Enron shares may have risen for years, but at the end of the day, shareholders received almost nothing. That's why I think questionable management is the worst flaw a company can have.

5. Companies that require continued capital investment
Over the long term, shareholders make spectacular returns by buying businesses that are able to achieve extraordinary returns on capital. This leads to excess capital that the company can use to repurchase shares, pay a dividend to shareholders, or reinvest in further growth. Companies that constantly need to make additional capital investment to keep the business going are the antithesis of this ideal -- the main beneficiaries will be employees, management, suppliers, and government. Take a look at Sprint Nextel and its performance over the last five years to substantiate this point. In other words, everyone profits except shareholders.

The upshot
These characteristics don't necessarily make a company a bad investment.Qualcomm, for instance, has been a great long-term investment despite ongoing R&D and capital expenditures. But a solid understanding of why these types of companies may be undesirable can help you identify whether a company that looks good on the surface might actually cost you money later.

We use similar techniques at Inside Value. With every stock, we cautiously evaluate each of these factors -- focusing on competitive advantages, potential threats, the balance sheet, and anything we can glean from SEC filings -- to determine whether the business is likely to provide a solid return for shareholders in the future. In our initial recommendation of any company, we discuss the risks the company faces and provide updates when new risks appear on the horizon.

By focusing on great businesses and understanding the potential risks of any company, we endeavor to achieve Buffett's first rule -- "Never lose money." To see the companies we've identified, take a 30-day guest pass to Inside Value. There's no obligation to subscribe.

This article was originally published on Oct. 7, 2005. It has been updated.

Fool contributor Richard Gibbons has forgotten what rule No. 2 is. He owns shares of UnitedHealth Group. Electronic Arts, Activision, and UnitedHealth are Motley Fool Stock Advisor recommendations. UnitedHealth and Sprint Nextel are Inside Value choices. The Motley Fool owns shares of UnitedHealth. The Motley Fool has a disclosure policy.