Track the companies that matter to you. It's FREE! Click one of these fan favorites to get started: Apple; Google; Ford.



Pfizer's Sutent Fails. Again!

Don't let it get away!

Keep track of the stocks that matter to you.

Help yourself with the Fool's FREE and easy new watchlist service today.

Another large market, another failure for Pfizer's (NYSE: PFE  ) Sutent.

The pharma giant announced yesterday that it was ending a trial testing Sutent in prostate cancer. The trial was supposed to continue through next year, but an interim peek at the data by the independent Data Monitoring Committee determined that Sutent wasn't going to be able to show an effect compared to placebo in prostate cancer patients that had failed sanofi-aventis' (NYSE: SNY  ) Taxotere.

Sutent isn't a complete failure, but the fact that it doesn't work in prostate cancer is a big loss for Pfizer. In fact, despite some successes, most of Sutent's failures have been big.


Estimated New Cases, 2010

Status of Sutent



Approved for a rare stomach cancer called gastrointestinal stromal cancer after Novartis' (NYSE: NVS  ) Gleevec.

Kidney and renal pelvis


Approved for advanced kidney cancer.



Positive results for a rare type called pancreatic neuroendocrine tumors.



Failed multiple trials on its own and in combination with other drugs.

Lung and bronchus


Failed to extend lung cancer survival when combined with Roche and OSI Pharmaceuticals' (Nasdaq: OSIP  ) Tarceva.

Liver and intrahepatic bile duct


Trial in liver cancer stopped early because it wasn't as efficient as Bayer and Onyx Pharmaceuticals' (Nasdaq: ONXX  ) Nexavar.




Source: American Cancer Society.

The incidence numbers don't translate perfectly with market size since they don't take into account cancer subtypes that might have different treatment options, but the trend is fairly obvious; Sutent hasn't performed well in the cancer types that could have boosted sales the most.

In the press release announcing the prostate cancer trial ending, Pfizer highlighted a trial testing Sutent in kidney cancer after surgery. Treating patients before they reach the advanced stage would boost sales, and the fact that Sutent already works against kidney cancer should give patients confidence that the trial might actually succeed.

Until the results are in, investors will just have to dwell on what could have been.

Alex Dumortier warns you not to buy stocks for the wrong reason.

Pfizer is a Motley Fool Inside Value selection. Novartis is a Motley Fool Global Gains recommendation. Try any of our Foolish newsletter services free for 30 days.

True to its name, The Motley Fool is made up of a motley assortment of writers and analysts, each with a unique perspective; sometimes we agree, sometimes we disagree, but we all believe in the power of learning from each other through our Foolish community.

Fool contributor Brian Orelli, Ph.D., doesn't own shares of any company mentioned in this article. The Fool has a disclosure policy.

Read/Post Comments (0) | Recommend This Article (0)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

Be the first one to comment on this article.

Compare Brokers

Fool Disclosure

Sponsored Links

Leaked: Apple's Next Smart Device
(Warning, it may shock you)
The secret is out... experts are predicting 458 million of these types of devices will be sold per year. 1 hyper-growth company stands to rake in maximum profit - and it's NOT Apple. Show me Apple's new smart gizmo!

DocumentId: 1315014, ~/Articles/ArticleHandler.aspx, 10/27/2016 6:59:33 AM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...

Today's Market

updated 9 hours ago Sponsored by:
DOW 18,199.33 30.06 0.17%
S&P 500 2,139.43 -3.73 -0.17%
NASD 5,250.27 -33.13 -0.63%

Create My Watchlist

Go to My Watchlist

You don't seem to be following any stocks yet!

Better investing starts with a watchlist. Now you can create a personalized watchlist and get immediate access to the personalized information you need to make successful investing decisions.

Data delayed up to 5 minutes

Related Tickers

10/26/2016 4:02 PM
NVS $71.13 Down -1.50 -2.07%
Novartis CAPS Rating: ****
ONXX.DL $0.00 Down +0.00 +0.00%
Onyx Pharmaceutica… CAPS Rating: **
OSIP.DL $0.00 Down +0.00 +0.00%
OSI Pharmaceutical… CAPS Rating: **
PFE $32.40 Up +0.12 +0.37%
Pfizer CAPS Rating: ****
SNY $37.06 Down -0.33 -0.88%
Sanofi CAPS Rating: *****