Moderna's (NASDAQ:MRNA) COVID vaccine made a fortune, then orders dried up, and the shares drifted for years. Then, on Wednesday, the stock jumped 177% on news of a clinical trial breakthrough. It gave back some gains on Thursday and closed at $133, still double where the week began, though far below its pandemic-era peak.
Moderna, a recommendation in Hidden Gems and Rule Breakers, makes medicines from mRNA, the same technology as its COVID shot. Its cancer vaccine candidate is built for each patient from their own tumor, then administered with Merck's (NYSE:MRK) drug Keytruda.
- A first in cancer medicine. The trial enrolled 1,137 melanoma patients whose tumors had been surgically removed. Those given the candidate with Keytruda saw cancer return less often than patients on Keytruda alone. The companies did not release specific figures, so we know it worked but not by how much. An earlier, smaller study showed a 49% lower risk of recurrence or death.
- Why one trial repriced the whole company. The approach can potentially target many cancers. Moderna is already testing it against lung, kidney, and bladder cancers.
- First comes FDA, then longevity evidence. The partners' next regulatory step is to file with the Food and Drug Administration, and CEO Stéphane Bancel thinks approval could happen in 2027. This week's data showed the drug candidate delays cancer's return; whether patients live longer will be answered in late 2029.