Better Buyout Candidate: Chelsea Therapeutics International Ltd. vs. InterMune Inc.

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As more key drugs come off of patent protection, one of the central themes in biotech this year is the buyout. Companies like AstraZeneca plc and Eli Lilly, that have been deeply stricken by the so-called patent cliff, will undoubtedly be on the lookout for new drugs or pipelines to compensate for falling revenue.

Fortunately, there are a fair number of smaller biotechs that could fill this need without breaking the bank. Chief among them, Chelsea Therapeutics  (NASDAQ: CHTP  ) and InterMune, (NASDAQ: ITMN  ) have bubbled to the top of many buyout lists. So, with this idea in mind, let's consider which company offers potential suitors the best opportunity. 

Chelsea offers its orphan drug Northera
Last month, the U.S. Food and Drug Administration, or FDA, approved Chelsea's drug Northera as a treatment for dizziness stemming from symptomatic neurogenic orthostatic hypotension, or NOH. The good news is that this is the first approved treatment for NOH.

The bad news is that the potential market is fuzzy because: NOH is poorly diagnosed, the FDA is requiring a large postmarketing study, and Northera's label will contain a black box warning about the increased possibility of hypertension. So, while analysts have suggested Northera could see peak sales anywhere from $300 million to $450 million, numerous hurdles lie ahead.

Because of these issues, Chelsea is said to be actively seeking either a partner to help commercialize Northera, or a buyer for the entire company. If management can't find either, the current plan is to launch Northera sometime in the second half of 2014.

That said, I think Chelsea is wise to seek a buyout here. At the end of the day, it would have to raise significantly more capital than the $45 million on hand to transition into a commercial operation and pay for a postmarketing study. Launching new drugs is expensive in its own right, and doubly so for companies brand new to this part of the business.

Besides Northera, Chelsea offers potential suitors an experimental drug, CH-4051, for Rheumatoid Arthritis that is currently in a mid-stage trial. 

InterMune counters with its orphan drug Esbriet
InterMune reported top-line data from a pivotal late-stage trial for Esbriet last month, where the drug easily met its primary and secondary endpoints as a potential treatment for idiopathic pulmonary fibrosis, or IPF. Investors and patients alike rejoiced over this news because IPF is a fatal disease with no treatment options approved by the FDA. InterMune shares have now risen 117% on the back of this stellar news, and the buyout rumors have started to swirl. Consequently, InterMune's market cap has ballooned to $2.8 billion, meaning that a buyout wouldn't come cheap. 

Why is InterMune a buyout target? Put simply, Esbriet is an orphan drug that is expected to become a blockbuster. Goldman Sachs analyst Terence Flynn believes Esbriet will see peak sales of around $1.3 billion. Beyond Esbriet, however, InterMune doesn't have a lot to offer a potential suitor. So, a deal would center chiefly around Esbriet's commercial value. 

Foolish wrap up
While I am optimistic about the upside potential of both companies, I think InterMune is a more attractive buyout candidate at the present time. Esbriet has a clearly defined target market and had stronger clinical trial results than Northera.

Presently, there are too many unknowns surrounding Northera's commercialization to get a good feel for how Chelsea should be valued. And I think the stock's volatile trading pattern, since Northera's approval, reflects this high degree of uncertainty.

That said, I think Chelsea would garner a higher premium than InterMune in a buyout scenario. Chelsea appears to be trading at a deep discount even under a pessimistic scenario for Northera's commercial prospects, which is probably because the market is anticipating a large secondary offering. In sum, I wouldn't be surprised if both companies end up getting bought out, but InterMune is this Fool's pick in a head to head comparison.


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Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

  • Report this Comment On March 18, 2014, at 1:17 PM, AndrewGreenBull wrote:

    At current price $6.18 and market cap 472 millions, who want to make a bid for the a drug with peak sale 330 millions in 2018 (according to JMP). If somebody does, that means he needs to bring at least 600 millions to the table to talk about potential 330 millions that may reach 4 years.

    So my conclusion is that there will be no deal for CHTP at this moment, all those buyout articles are just authors imagination or other purposes.

  • Report this Comment On March 19, 2014, at 9:25 AM, tomstav wrote:

    With all the falling revenues caused by loss of exclusivity Pharma companies are on the lookout for small biotech with potential for big revenues or at least something big enough that has a good chance of getting commercialized. For Pharma companies, an external deal has to provide a much better return than its own internal portfolio.

    Given all the uncertainty surrounding Chelsea Therapeutics' key drug and its revenue potential, the chance for a buyout of this company is unlikely. Intermune is a whole different story - its product is already marketed with high revenue potential and significant additional potential comes from upcoming US launch. Intermune is in a different league and comparing this company as a buyout candidate to Chelsea is like comparing apples to oranges.

  • Report this Comment On March 19, 2014, at 10:17 PM, Topdoginvesting1 wrote:

    Chtp has only 18 employees. Not nearly enough to get the Drug Out there. Merger or Buyout is in the works. Insiders have sold none. Sales between 400 to 600 million will help the bottom line of any big Pharma. As for ITMN, Shorts are up, but the huge insider selling is enough to scare me off. I wish the best to shareholders of both.

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George Budwell

George Budwell has been writing about healthcare and biotechnology companies at the Motley Fool since 2013. His primary interests are novel small molecule drugs, next generation vaccines, and cell therapies.

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12/31/1969 7:00 PM
CHTP $0.00 Down +0.00 +0.00%
Chelsea Therapeuti… CAPS Rating: **
ITMN $0.00 Down +0.00 +0.00%
InterMune CAPS Rating: **