Although we don't believe in timing the market or panicking over market movements, we do like to keep an eye on big changes -- just in case they're material to our investing thesis.

What: Shares of Dendreon (NASDAQ:DNDN), a biopharmaceutical company focused on developing immunotherapy vaccines to treat cancer, dipped as much as 15% after reporting disappointing first-quarter earnings results, and receiving a subsequent analyst downgrade.

So what: For the quarter, Dendreon delivered product revenue from its late-stage prostate cancer vaccine Provenge, of $68.8 million, up slightly from the $67.6 million it reported in the prior-year period. Net loss was nearly halved, to $36.4 million, or $0.24 per share, from $72 million, or $0.48 per share, following its second restructuring in as many years aimed at cutting costs. It also ended the quarter with approximately $170 million in cash, cash equivalents, and investments. Comparatively, Wall Street expected a wider loss of $0.28 per share, but had been expecting $69.1 million in revenue. In spite of the revenue miss, it was the first quarter of year-over-year sales growth in some time.

In response to its earnings release, Maxim Group downgraded the company to hold from buy, and set a $1 price target on shares. However, if someone can explain Maxim's logic of how a greater-than-50% expected drop in Dendreon's share price equates to a hold rating, I'd love to hear it!

Now what: On the surface, there are snippets of good news for optimists to wrap their hands around, including Dendreon's reduced cash burn rate of $30 million for the quarter, and its improved year-over-year sales. But the reality is that the competition in the advanced prostate cancer space is so fierce that even with a second round of cost cutting, it's not ensured that Dendreon will ever be profitable. Investors and I were both looking for a much bigger boost from Provenge sales given that its top-line targeted accounts surged to 93 in Q1 2014 compared to 54 in Q1 2013. Based on this data, I see no enticing reasons to buy into Dendreon's shares here, and would suggest staying away from this still-sinking ship.

Dendreon may still have a chance to rebound; but even if it does it'll likely be no match for this top stock over the long run
Give me five minutes, and I'll show how you could own the best stock for 2014. Every year, The Motley Fool's chief investment officer handpicks one stock with outstanding potential. But it's not just any run-of-the-mill company; it’s a stock perfectly positioned to cash in on one of the upcoming year's most lucrative trends. Last year, his pick skyrocketed 134%. And previous top picks have gained upwards of 908%, 1,252%, and 1,303% during the subsequent years! Believe me, you don't want to miss what could be his biggest winner yet! Just click here to download your free copy of "The Motley Fool's Top Stock for 2014" today.

Sean Williams has no material interest in any companies mentioned in this article. You can follow him on CAPS under the screen name TMFUltraLong, track every pick he makes under the screen name TrackUltraLong, and check him out on Twitter, where he goes by the handle @TMFUltraLong.

Try any of our Foolish newsletter services free for 30 days. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.