Track the companies that matter to you. It's FREE! Click one of these fan favorites to get started: Apple; Google; Ford.



No Drugs, No Rally

It didn't take investors too long to do the math. One drug in late-stage trials minus one drug failure equals zero drugs. That last number is also the price that Sonus Pharmaceuticals' (Nasdaq: SNUS  ) stock approached Monday, when it shed a whopping 84% of its value.

Sonus is developing Tocosol paclitaxel, a reformulated version of Bristol-Myers Squibb's (NYSE: BMY  ) Taxol, for treating breast cancer patients. Unfortunately for Sonus, the news out of the phase 3 trial couldn't have been any worse than it was.

To gain marketing approval, the drug just needed to work equally well, but have fewer side effects, than Taxol. Or the drug could also have done well in the market if it had performed better than the standard treatment with similar side effects. Instead, the drug did worse in both categories.

Based on the results, Sonus expects its marketing partner, Bayer (NYSE: BAY  ) , to drop it like a bad habit. The company is checking the data thoroughly to see if there's something different about the phase 3 trial that explains why it went so badly compared with the rather stellar phase 2 trial results. But I'm not holding out hope on that front; sometimes phase 2 trials just aren't big enough to give a true picture of the drug's effectiveness and safety.

The best chance for Sonus to find redemption in the stock market is a reformulated version of Camptothecin, based on the same Tocosol technology, in phase 1 clinical trials. Before the trial results were announced, the company had expected to have $22 million to $25 million in cash at the end of the year, but it should have more because it won't need to pay for the late-stage clinical trial. I'm not sure that will be enough money to get it through a phase 2 trial, so it will probably need to get a partner to take over the funding. I'd guess a dilutive financing is almost guaranteed at this point.

On the winning side of the trial results was Abraxis BioScience (Nasdaq: ABBI  ) . The company makes Abraxane, an albumin-based formulation of Taxol, which has been competing exceptionally well against Bristol-Myers' Taxol and Sanofi-Aventis' (NYSE: SNY  ) Taxotere. Without the added competition, Abraxis should have an easier time with its plunder of the taxane market.

Read/Post Comments (0) | Recommend This Article (3)

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

Be the first one to comment on this article.

Compare Brokers

Fool Disclosure

Sponsored Links

Leaked: Apple's Next Smart Device
(Warning, it may shock you)
The secret is out... experts are predicting 458 million of these types of devices will be sold per year. 1 hyper-growth company stands to rake in maximum profit - and it's NOT Apple. Show me Apple's new smart gizmo!

DocumentId: 537429, ~/Articles/ArticleHandler.aspx, 10/22/2016 9:29:41 PM

Report This Comment

Use this area to report a comment that you believe is in violation of the community guidelines. Our team will review the entry and take any appropriate action.

Sending report...

Today's Market

updated 1 day ago Sponsored by:
DOW 18,145.71 -16.64 -0.09%
S&P 500 2,141.16 -0.18 -0.01%
NASD 5,257.40 15.57 0.30%

Create My Watchlist

Go to My Watchlist

You don't seem to be following any stocks yet!

Better investing starts with a watchlist. Now you can create a personalized watchlist and get immediate access to the personalized information you need to make successful investing decisions.

Data delayed up to 5 minutes

Related Tickers

10/21/2016 4:01 PM
BMY $50.02 Down -0.34 -0.68%
Bristol-Myers Squi… CAPS Rating: ****
SNY $37.75 Down -0.32 -0.84%
Sanofi CAPS Rating: *****