Lost in yesterday's hubbub about Merck
Schering's clinical trial -- dubbed IDEAL, an acronym invented by some guy with too much time on his hands -- was a post-marketing requirement from the FDA. It mandated testing for two doses of hepatitis C virus treatment Pegintron, to see if the lower dose worked as well with fewer side effects. Since it was going to have to spend all that time and money running the trial, Schering threw Pegintron's competitor, Roche's Pegasys, into the mix as well.
Around 40% of patients taking the two Pegintron doses -- as well as those taking Pegasys -- showed a sustained virologic response. That is, they didn't have detectable levels of the virus after treatment. For Schering, that's a win, since Pegintron isn't selling as well as Pegasys.
The better news for Schering was that fewer Pegintron patients relapsed compared to the Pegasys patients. Schering didn't give any statistics for the trial, so one has to wonder if the difference is due to chance alone.
Roche, however, is crying foul. The drugmaker claims that, by using different doses of ribavirin -- a drug used in combination with both of the drugs -- for Pegintron and Pegasys, Schering set up Pegasys for failure. Schering seems to have seen this argument coming, and noted that it used the "recommended doses in accordance with their approved U.S. labeling"; it even presented the data for just those taking comparable doses of ribavirin.
With so many potential new hepatitis C drugs in the clinic, now is the time for the two companies to try and establish dominance. Not only do these drugs have potential competitors in the works, but some of the new drugs, such as Vertex Pharmaceuticals'
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