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Technically, Human Genome Sciences (Nasdaq: HGSI) has one drug for sale, but it's between shipments of ABthrax, its anthrax treatment, to the government, so Human Genome's earnings release Thursday was rather dry.

The company recorded a measly $18.8 million in revenue from partnerships with GlaxoSmithKline (NYSE: GSK) and Novartis (NYSE: NVS) and lost a lot of money, though less than last year. You get the picture.

But don't let the nature of the (mostly) drugless biotech lull you to sleep. Like a good horror flick, there's something lurking in the woods, and it's going to send the stock moving in one direction or the other on the other side of Halloween.

On Monday, we'll get to hear the results from the second phase 3 trial of Benlysta in systemic lupus erythematosus (SLE) patients. The suspense has been growing since Human Genome and its partner Glaxo announced the release date a few weeks ago. It's rare that investors get more than an overnight warning of the release of phase 3 trial results. Usually companies want to get them out as soon as the data is compiled.

Just a few months ago, no one gave the drug much chance of working, but the first phase 3 trial was positive and the stock is up more than 500% since then. That success should give investors confidence that the second trial will work, but it doesn't guarantee success, as InterMune's (Nasdaq: ITMN) 50% success rate in phase 3 trials shows.

The risk of failure is also increased because Benlysta treats lupus -- the place where good drugs go to die. Biogen Idec (Nasdaq: BIIB), Teva Pharmaceutical (Nasdaq: TEVA), and BioMarin Pharmaceuticals (Nasdaq: BMRN) all have drugs in the lupus graveyard, and a new drug hasn't been approved specifically to treat it in decades.

The way I see it, there's less upside potential than downside risk at this point, and I'll take a pass and watch from the sidelines while munching on leftover Halloween candy Monday morning.

Got a different take? Let us know in the comments box below.

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BioMarin and InterMune are Motley Fool Rule Breakers recommendations. The newsletter team is always on the hunt for hot drug stocks and other cutting-edge picks. See all of our latest discoveries with a free 30-day trial.

Fool contributor Brian Orelli, Ph.D., buys the variety pack and then hands out all the candy he doesn't like first. He doesn't own shares of any company mentioned in this article. Novartis is a Global Gains selection. Despite eating a Snickers every day, the Fool's disclosure policy is never satisfied with protecting your interests.

Comments from our Foolish Readers

Help us keep this a respectfully Foolish area! This is a place for our readers to discuss, debate, and learn more about the Foolish investing topic you read about above. Help us keep it clean and safe. If you believe a comment is abusive or otherwise violates our Fool's Rules, please report it via the Report this Comment Report this Comment icon found on every comment.

  • Report this Comment On October 30, 2009, at 4:21 PM, wbcm wrote:

    You should change your name from "motley fool" to "Motley genius". Your article is well researched and full of logic. If you would not have posted just before the market close, nobody would doubt your well intentions too. Long live motley genius!

  • Report this Comment On October 31, 2009, at 7:34 AM, BIGJIMT wrote:

    Brian your article was humorous and almost 100%

    perfect in every way. But if you would have started off

    with 'MRNA', your article would have been flawless.

    To embellish a little, first you have to have the fairy tale shareholders who believe sincerely, that they have found the golden goose. The love affair between shareholders and the company is like a mother and son. In this case the company can do no wrong.

    Even though the stock has retreated from $20 dollars to $1.04, and between today, Oct.31st until the end of the year the logical trend is further downward, they remain loyal just like a cult of sorts.

    Terrible qtly earnings, No serious earnings revenues,

    early pre-clinical stage testing results, and stats that resemble a rap sheet of a convicted thug, shareholders hang on for dear life.

    Lastly, shareholders should only know the answer to one big question right now. And that is where will the company, 'MRNA', attain the money quickly, to be

    able to function further through all of 2010?

    The 2010 expenses is far from a small piece of change. The shareholders should receive the

    'FOOL OF THE YEAR AWARD".

    TRICK OR RETREAT

  • Report this Comment On November 02, 2009, at 7:19 PM, mauraannerudy wrote:

    BIGJMT - you must not know very much about HGSI or its biz model. And I say that as a scientist, not a serious investor! I'm glad I didn't take the advice mentioned herein. Even if Benlysta tanked; I bought my shares at 1.36. :)

  • Report this Comment On November 03, 2009, at 4:22 PM, LatifK wrote:

    Even after the fact, it was a good advice. The upside potential was limited and downside was...well a graveyard.

    Playing this outright with a stock purchase you would be putting $18 at risk for a possibility of an 80%-90% loss OR a possible 20% gain. NOT a good idea no matter how religious you are about this or any stock.

    That being said, you could have still played this to perfection with options. A simple call spread would have kept you in for the upside and a way out of the money put purchase would have covered you from any devastating news.

    The chances of it staying flat was virtually non-existent.

    Events like these are what option traders live for.

    Cheers-

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11/20/2009 4:00 PM
BIIB $46.38 Up +0.53 +1.16%
Biogen Idec, Inc. CAPS Rating: ****
ITMN $10.79 Down -0.09 -0.83%
InterMune, Inc. CAPS Rating: **
BMRN $16.97 Down -0.37 -2.13%
BioMarin Pharmaceu… CAPS Rating: ****
NVS $53.13 Down -0.16 -0.30%
Novartis AG (ADR) CAPS Rating: *****
GSK $41.53 Up +0.06 +0.14%
GlaxoSmithKline pl… CAPS Rating: *****
TEVA $52.72 Down -0.32 -0.60%
Teva Pharmaceutica… CAPS Rating: *****
HGSI $27.38 Up +0.16 +0.59%
Human Genome Scien… CAPS Rating: **

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