If you're looking to invest in marijuana stocks, the U.S. is where the big money lies. In this brief Fool Live video, Healthcare and Cannabis Bureau Chief Corinne Cardina and longtime Motley Fool contributor Keith Speights discuss which stock is the best pure-play U.S.-based marijuana stock. Two candidates rise to the top.

Corinne Cardina: One question before we wrap up the hour. Mike would like to know who you consider to be the best positioned pure-play in the U.S. market? Is there one with better balance sheets and management that you consider to be at the top?

Keith Speights: Wow. That's a tough question. I'm going to answer in two ways really quickly.

At this moment in time, I would say that Trulieve Cannabis (OTC:TCNNF) would probably be the top. They're profitable, they absolutely dominate the Florida medical cannabis market, and they're looking to expand into other states.

Over the longer term, a stock that I would really keep my eye on is Cresco Labs (OTC:CRLBF). Cresco, they're very similar to Green Thumb Industries. They're based in Illinois. They have a lot of growth opportunities.

Watch two states voting in November -- Arizona and New Jersey. I think Cresco is positioned well to move into both of those states if they legalize recreational marijuana.

This article represents the opinion of the writer, who may disagree with the “official” recommendation position of a Motley Fool premium advisory service. We’re motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.