Patience is a lesson the stock market is more than willing to teach. Despite undergoing 38 crashes or corrections since 1950, the benchmark S&P 500 has eventually put every single decline firmly in the rearview mirror and blasted to new highs.

Patience can be especially valuable when putting your money to work in high-growth, innovative businesses. Allowing your investment thesis to play out over many years could turn a sizable sum of cash into a life-changing amount of money.

If you have $100,000 to invest that won't be needed to cover bills or emergencies, the following four stocks each have the potential to turn a $100,000 investment into $500,000 (or more) by 2030.

A messy pile of one hundred dollar bills.

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Teladoc Health

It's easy for investors to point to the coronavirus pandemic and proclaim that telehealth service giant Teladoc Health (NYSE:TDOC) was a one-off beneficiary. The company did, indeed, see virtual visits on its platform surge to almost 10.6 million from 4.1 million in 2019. But thinking this is just a one-time bump-up in demand would be a mistake. We're witnessing a transformation of personalized care in this country, and Teladoc Health is on the leading edge of this change

Telemedicine provides benefits up and down the healthcare treatment chain. Virtual visits are substantially more convenient for patients, and it can allow physicians to better keep in touch with chronically ill patients that need regular monitoring. Even though virtual visits can't replace in-person care or exams in all situations, it provides physicians with a powerful tool to improve patient outcomes. That means better quality of life for patients, as well as less money out of the pockets of health-benefit providers.

Teladoc Health also differentiated itself by acquiring leading applied health signals company Livongo Health during the fourth quarter of 2020. Livongo collects mountains of data on patients with chronic illnesses and leans on artificial intelligence to send tips or nudges to its members to help them lead healthier lives. Prior to being acquired, Livongo was already profitable on a recurring basis, and was well on its way to expanding its services to include people with hypertension and weight management issues, on top of its existing service for diabetics.

Teladoc is the face of sweeping healthcare innovation, and it could quintuple your initial investment by 2030.

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Sea Limited

Speaking of innovative companies that can seriously multiply your initial investment, say hello to Singapore-based Sea Limited (NYSE:SE). Sea's secret to success over the coming years will be its three rapidly growing operating segments.

For the time being, its gaming division is responsible for all of the company's positive earnings before interest, taxes, depreciation, and amortization (EBITDA). Last year, Wappier Games estimated that between 1.6% and 2% of gamers were converted to paying customers. At the end of March 2021, 12.3% of Sea's active quarterly users were paying to play, which is up from 8.9% in the prior-year period. 

While it's great to see such resounding success in the company's digital entertainment division, the future of Sea rests with its e-commerce operations. Online shopping platform Shopee is targeting a number of rapidly growing emerging markets, including Southeastern Asia and Brazil. Like Teladoc, it was a clear beneficiary of the pandemic, with consumers shopping online from the safety of their homes. But gross orders and gross merchandise value transacted on Shopee were rocketing higher well before the pandemic. Sea is quickly becoming a force within e-commerce.

Lastly, the company's nascent digital financial services segment is growing very rapidly. Since some of the markets Sea operates in are underbanked, being able to offer digital wallet services could prove a game-changer. The company already has over 26 million paying digital wallet customers.

Together, these segments could make Sea one of the largest companies in the world within the next decade.

A close-up of a flowering cannabis plant.

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Jushi Holdings

Investors with a nose for making money would be wise not to overlook marijuana stocks. But make no mistake about it, the U.S. is the cannabis epicenter where you'll want to consider putting your money to work. That's why small-cap U.S. multistate operator Jushi Holdings (OTC:JUSHF) can make investors rich.

Whereas most pot stocks are angling to have a presence in as many markets as possible, Jushi's core focus is on three markets: Pennsylvania, Illinois, and Virginia. At the moment, Jushi has 20 operational dispensaries, 13 of which are located in Pennsylvania.  Why these states? The simple answer is that they all limit the number of retail licenses issued. Pennsylvania and Illinois cap retail license issuance, while Virginia assigns licenses by jurisdiction. The point is this: Jushi is being allowed to build up its brand and a loyal following in these three states without being overrun by competition.

It may be small in stature ($945 million market cap), but Jushi isn't afraid to use its cash to its advantage. The company has increased its cultivation and/or retail presence in Virginia and Pennsylvania with acquisitions, and recently closed on the purchase of two dispensaries in California. The Golden State is the biggest cannabis market in the world.

Should you desire one additional reason to buy into the Jushi growth story, here it is: Executives and insiders ponied up $45 million of the first $250 million raised by the company. When insiders have skin in the game, positive things typically happen for shareholders.

A person inserting a credit card into a Square point-of-sale device.

Image source: Square.

Square

Another game-changing company that has all the tools necessary to turn a $100,000 initial investment into $500,000 by 2030 is fintech stock Square (NYSE:SQ). Square has two operating segments working in tandem that have it on the leading edge of innovation in the payment space.

Square's foundational operating segment is its seller ecosystem, which provides point-of-sale devices, loans, analytics, and other tools to help small businesses thrive. In the seven years leading up to the pandemic, the gross payment volume (GPV) traversing Square's network grew by an annualized rate of 49%. Although this payment network is predominantly designed to help out small businesses, payment data shows that a majority of GPV now originates from medium-and-large-sized companies. For a segment dependent on merchant fees, this is great news.

However, the bigger growth story is peer-to-peer payment platform Cash App. It took three years for Cash App's monthly active user count to more than quintuple to 36 million. This online app allows Square to collect revenue from bank transfer fees, merchant fees, and investment commissions/fees, including on Bitcoin, the world's largest cryptocurrency by market cap. 

Square might appear pricey following its epic post-coronavirus crash run higher, but its revenue is on track to more than triple by 2024. Like Sea, it could very well become one of the largest companies in the world sooner than you realize.

This article represents the opinion of the writer, who may disagree with the “official” recommendation position of a Motley Fool premium advisory service. We’re motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.