The following video is part of our "Motley Fool Conversations" series, in which, David Williamson, health-care editor and analyst, and Austin Smith, consumer-goods editor and analyst, discuss topics around the investing world.

In today's edition, David and Austin take a look at the worst health-care performers of 2012, focusing on the worst performer of the year, Dendreon. This video reflects back on the year that was but also takes a look at what Dendreon needs to do to be successful in 2012 and the threats on the company's horizon.

Austin Smith owns no shares of the companies listed above. David Williamson owns shares of Dendreon and Johnson & Johnson. The Motley Fool owns shares of Devon Energy and Dendreon. Motley Fool newsletter services have recommended buying shares of Vertex Pharmaceuticals. Try any of our Foolish newsletter services free for 30 days. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.