Today, Fool.com health-care analysts Brenton Flynn and David Williamson look at an unexpected downgrade of Amarin from Wedbush Securities. While Wedbush still believes the company makes for an attractive target, it's less optimistic that a Big Pharma buyout will happen as early as previously expected.

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Brenton Flynn and Dave Williamson have no positions in the stocks mentioned above. The Motley Fool owns shares of GlaxoSmithKline. Motley Fool newsletter services recommend GlaxoSmithKline. Try any of our Foolish newsletter services free for 30 days. We Fools don't all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.