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Date

Thursday, April 30, 2026 at 4:30 p.m. ET

Call participants

  • Chairman & Chief Executive Officer — Robert A. Bradway
  • Executive Vice President, Global Commercial Operations — Murdo Gordon
  • Executive Vice President, Research and Development — James E. Bradner
  • Executive Vice President & Chief Financial Officer — Peter H. Griffith

Takeaways

  • Six key growth drivers -- Generated $5.6 billion in sales for the quarter, accounting for 70% of total product sales, with aggregated year-over-year growth of 24%.
  • Total product sales growth -- Increased 4% year over year, driven by diversified, fast-growing products offsetting exclusivity losses.
  • Repatha sales -- Achieved $876 million, up 34% year over year, following increased treatment urgency and expanded guidelines.
  • Evenity sales -- Delivered $562 million, reflecting 27% year-over-year growth; achieved 35% U.S. sales growth and 65% U.S. market share.
  • Test Buyer sales -- Reported $343 million, a 20% increase, with new indication adoption supporting expansion.
  • Prolia and XGEVA sales -- Combined sales totaled $1.1 billion, a decline of 32% year over year, attributed to exclusivity loss and anticipated continued erosion.
  • Rare disease portfolio -- Delivered $1.2 billion, up 25% year over year; Eplizna sales surged 188% to $262 million.
  • TEPEZZA sales -- U.S. revenues reached $490 million, growing 29%, supported by interest in new subcutaneous delivery data and expanded specialist prescribing.
  • TAVNEOS sales -- Realized $119 million, up 32%, reflecting robust volume growth and continued patient uptake since launch.
  • Innovative oncology portfolio -- Produced $1.8 billion in sales, up 25% year over year, led by IMDELTRA ($258 million) and BLINCYTO ($415 million).
  • Biosimilars portfolio -- Contributed $835 million, a 14% year-over-year increase; PABLUE registered $280 million.
  • Non-GAAP operating margin -- Reported at 45% for the quarter; management expects similar margin next quarter.
  • Non-GAAP R&D spending -- Rose 16% year over year, attributed to late-stage investments (Meritide, IMDELTRA, and opazirand).
  • Non-GAAP cost of sales -- Reached 19.5% of product sales due to higher profit share, royalty expenses, and sales mix changes, with further pressure expected.
  • Free cash flow -- Generated $1.5 billion amid ongoing business momentum.
  • Capital expenditures -- Totaled $700 million, with $2.6 billion forecast for the year, primarily for manufacturing expansion including Meritide launch readiness.
  • Dividend -- Paid $2.52 per share in the quarter, increasing 6% from 2025.
  • 2026 revenue guidance -- Raised to a range of $37.1 billion–$38.5 billion, reflecting confidence in portfolio execution.
  • 2026 non-GAAP EPS guidance -- Increased to $21.70–$23.10.
  • 2026 non-GAAP operating margin outlook -- Confirmed at 45%–46% of product sales.
  • 2026 non-GAAP tax rate guidance -- Updated to 15%-16.5%.

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Risks

  • Prolia and XGEVA sales decline -- Management expects "accelerated sales erosion over the remainder of 2026 driven by increased competition from multiple biosimilars."
  • Non-GAAP cost of sales pressure -- CFO Griffith stated ongoing drivers will "continue to negatively impact the cost of sales in future quarters."
  • Tax disputes -- CFO Griffith disclosed receipt of a draft Notice of Proposed Adjustment from the IRS for tax years 2016–2018 and warned, "If sustained in full, the adjustments set forth in the draft NOPA could have a material impact on our financial statements."
  • TAVNEOS regulatory uncertainty -- The company noted the FDA has "proposed to withdraw the approval of Tabneos" and will engage further on the issue.

Summary

Amgen (AMGN +2.44%) delivered fiscal first quarter results featuring broad-based growth across multiple product lines and raised its 2026 guidance for both revenue and non-GAAP earnings per share. The Meritide clinical program advanced, launching multiple Phase 3 switch and maintenance studies, and reported incremental progress in differentiated dosing and improved tolerability. Tangible adoption and new evidence propelled Repatha, Evenity, Test Buyer, and TEPEZZA, while biosimilars and rare disease portfolios continued contributing to sales expansion. Innovative pipeline advancement was highlighted by late-phase programs for Meritide, Olpasiran, and IMDELTRA, as well as AI-driven R&D and operational initiatives targeting increased efficiency. Operational and financial risks were cited, including cost of sales pressure, ongoing accelerated legacy brand erosion, and heightened uncertainty related to IRS tax disputes.

  • The Meritide program initiated two Phase 3 studies to evaluate longer-term maintenance dosing and switch from weekly GLP-1 therapies, with new data indicating increased tolerability and patient persistence potential.
  • Updated results from the VESALIUS-CV study documented a 31% reduction in major adverse cardiovascular events for Repatha in high-risk diabetes patients, reinforcing leadership in both primary and secondary cardiovascular prevention segments.
  • Positive Phase 3 data for the subcutaneous on-body delivery of TEPEZZA demonstrated efficacy equivalent to intravenous administration and supported future global launches and expanded patient access.
  • The innovative oncology pipeline saw expanded efforts for IMDELTRA and new enrollment in next-line studies, including real-world trial pilots with the FDA focused on accelerated clinical evidence gathering using electronic health records.
  • Amgen detailed AI adoption in manufacturing and R&D, with reported 50% faster antibody lead optimization and a threefold improvement in clinical trial enrollment at select sites.
  • Biosimilars portfolio cumulative sales surpassed $14 billion since initial approvals in 2018, extending reach for affordable biologics and supporting continued top-line growth.
  • The company confirmed that guidance does not reflect any potential business development deals that may arise later in the year.

Industry glossary

  • PCSK9 inhibitor: Drug class that lowers LDL cholesterol by targeting the PCSK9 protein, used in cardiovascular prevention (e.g., Repatha).
  • GLP-1 therapy: Glucagon-like peptide-1 receptor agonists, a class of drugs mainly for diabetes and obesity; allows appetite suppression and glycemic control.
  • Biosimilar: A highly similar, lower-cost version of an approved biologic medicine, matching safety, purity, and efficacy.
  • BiTE: Bispecific T cell engager, a type of antibody construct designed to direct T cells to target and kill cancer cells.
  • Lp(a): Lipoprotein(a), a genetically determined cardiovascular risk biomarker targeted by agents such as Olpasiran.
  • On-body injector: A drug delivery device attached to the patient’s body to enable subcutaneous administration of therapeutics.
  • ESSDAI: EULAR Sjogren's Syndrome Disease Activity Index, measures systemic disease activity in Sjogren's syndrome clinical trials.
  • ESSPRI: EULAR Sjogren's Syndrome Patient Reported Index, quantifies symptoms in patients participating in Sjogren’s syndrome studies.
  • NOA: Notice of Proposed Adjustment; preliminary IRS communication proposing tax liability changes following an audit.

Full Conference Call Transcript

Robert A. Bradway: Good afternoon, and thank you for joining us. We had a strong first quarter and are well positioned to achieve our objectives for the year. Recall, we previously described 2026 as a springboard year for Amgen Inc., a year in which we expect our rapidly growing products to offset the financial impact of patent expirations and increased competition while our next generation of molecules progress through the R&D pipeline, setting the stage for sustained long-term growth. As you can see from our progress thus far, we are on track to achieve these objectives.

With steady execution through the rest of the year, we expect once again to demonstrate that we can grow through a period of patent expiration, and deliver attractive performance for our shareholders with a strong portfolio of innovative medicines and biosimilars that meet the needs of patients with serious diseases. As you listen to Murdo’s presentation in a moment, note the momentum of our six key growth drivers. Together, they generated 70% of our sales in the quarter and grew in aggregate by 24%. That strong performance sets us up well for the year and well beyond.

Turning to the pipeline, our focus this year is on disciplined data generation and execution across a number of important Phase 3 programs, again we expect will drive attractive long-term growth for Amgen Inc. Our confidence in Meritide as a differentiated treatment for obesity, type 2 diabetes, and obesity-related conditions continues to build. We are executing effectively across the company, building the capabilities we need to bring this medicine to market. As Jay will discuss in a moment, we are disclosing additional Phase 3 studies of Meritide, one of which will evaluate switching from the weekly injectables to Meritide on an every eight or twelve week schedule.

In other words, we will evaluate switching from medicines which are injected 52 times a year to one which can be injected as few as four or six times a year. In addition, we will evaluate weight maintenance for Meritide on a schedule of four or six injections a year as well. Expect there to be a great deal of interest in these data. Beyond Meritide, we see strong potential across a number of other programs in late-stage development, including opazirand, and other innovative programs in Phase 3. We have talked about the excitement we feel about the convergence of technology and biology including the application of artificial intelligence across the company. Here too, we are making great progress.

And there is no question we are in a period of tremendous change and we are encouraged by the progress we are making in embedding new capabilities. We are doing this across the company and we took steps early on to have Dave Reese lead these efforts, and we are grateful to him for the success he has achieved with this initiative. And we are encouraged that James E. Bradner will build on Dave’s accomplishments leading our artificial intelligence and data activities across the company. I will have more to say about Dave at the end of the call.

But before we turn to Murdo, let me just thank my Amgen Inc. colleagues around the world for their dedication to our mission to serve patients and the quality of their work again this year. Murdo?

Murdo Gordon: Thanks, Bob. As mentioned, in 2026, 16 products achieved double-digit or better sales growth and 17 products are now annualizing at sales of $1 billion or more. Overall, we delivered 4% growth in product sales driven by a diversified portfolio of fast-growing products that continues to outpace the impact of losses of exclusivity. The evolution of our business is now well underway, with our six key growth drivers, which include Repatha, Evenity and Testfire, three innovative medicines delivering significant clinical benefit for large populations of undertreated patients. Also included are our rare disease, innovative oncology, and biosimilars portfolios.

Collectively, these growth drivers delivered 24% year-over-year sales growth and generated $5.6 billion in sales in the first quarter, representing almost 70% of total product sales. Starting with general medicine, Repatha delivered $876 million in first quarter sales, up 34% year over year. Growth was driven by increased urgency to treat patients in both secondary prevention and high-risk primary prevention, where intensive LDL-C lowering with Repatha significantly reduces major cardiovascular events. The ACC/AHA updated their dyslipidemia guidelines now reinforcing earlier risk identification, lower LDL-C levels and targets, and earlier use of therapy like Repatha. These guidelines do not yet reflect the practice-changing VESALIUS-CV data, leaving a clear opportunity to further evolve clinical guidelines and quality measures.

We expect these additional changes will further encourage cardiologists and primary care physicians to manage LDL-C levels below 50 milligrams per deciliter, alongside lifestyle modification to reduce cardiovascular risk in both primary and secondary prevention. Physician response to our landmark VESALIUS-CV study has been strong with sustained increases in new-to-brand prescribing across cardiology and primary care, particularly in support of high-risk primary prevention patients with diabetes. At the recent ACC meeting, the VESALIUS-CV subgroup analyses in patients with diabetes and without known significant atherosclerosis was presented and simultaneously published in JAMA. These data further reinforce the consistent and significant benefit of Repatha, delivering a 31% reduction in cardiovascular events. A trend in lowering mortality rates was also observed.

The body of evidence is now very clear. Treating patients earlier with Repatha can lower cardiovascular events. In the U.S., Amgen Inc. now is further strengthening access to Repatha by offering a simplified cash-pay option to patients. We are seeing encouraging patient interest in this direct access model which now also includes Enbrel, Otezla, Aimovig, and Amjevita. Repatha is now the only PCSK9 inhibitor with positive outcomes data in both high-risk primary and secondary prevention patients. These data, along with Repatha’s broad access, create an imperative to close the treatment gap for millions of patients for whom Repatha can help reduce heart attacks and strokes and potentially save lives. Evenity sales increased 27% in the first quarter to $562 million.

U.S. sales grew 35% year on year and Evenity maintains leadership of the U.S. bone builder market with a 65% market share. To date, approximately 320,000 U.S. patients have been treated with Evenity, supported by increased investment and an expanded field force. However, the unmet need remains significant with more than 90% of the 2 million women at very high fracture risk remaining untreated, presenting a clear opportunity to expand the market and drive additional Evenity growth and impact. In Japan, Evenity has been prescribed to more than 900,000 patients since launch, and it leads the bone builder category with over 55% market share.

We see a positive reaction to the treatment guideline updates by the Japan Osteoporosis Society, which further improves Evenity’s positioning and potential. Moving to inflammation, Test Buyer sales grew 20% year over year, reaching $343 million in the first quarter, driven by robust patient demand and solid execution across both pulmonology and allergy specialties, partially offset by a burn in channel inventory. Test Buyer remains well positioned to reach more patients in the U.S. given its differentiated TSLP mechanism that targets multiple inflammatory pathways driving uncontrolled asthma, including in those patients with coexisting chronic rhinosinusitis with nasal polyps. This new indication is gaining traction and helping expand Test Buyer’s reach across a broader patient population.

Prolia and XGEVA combined delivered $1.1 billion in sales in the first quarter, a decrease of 32% year over year. Erosion since loss of exclusivity remains in line with our expectations; we anticipate accelerated sales erosion over the remainder of 2026 driven by increased competition from multiple biosimilars. Our rare disease portfolio grew 25% year over year to $1.2 billion. Eplizna sales increased 188% year over year to $262 million in the first quarter, reflecting growing demand across all three approved indications. We are encouraged by the pace of growth and the potential that Oplizna has to help patients living with rare autoimmune conditions with significant unmet need.

The plasma’s uptake in gMG has been strong across both bio-naïve and switch patients, supported by broad access for most covered patients with requiring a step through another approved biologic. Given this momentum, we see a meaningful opportunity for Eplisna to become the first line and first switch choice for appropriate patients living with gMG. Momentum in IgG4-related disease continues, the plasma adoption led by rheumatologists and increased prescribing by GI specialists and nephrologists. In NMOSD, Iplisna continues to maintain its leadership as the most prescribed FDA-approved therapy in the U.S. TEPEZZA sales grew 29% in the first quarter, to $490 million in the U.S.

More than 25,000 patients have been treated since launch with growing interest from both new and returning prescribers, increased prescribing from endocrinologists and a broadening specialist base. We see rising awareness of moderate thyroid eye disease in the U.S. This positions TEPEZZA for growth, supported by its best-in-class efficacy, well-established safety profile, industry-leading patient services, and broad payer coverage. We are also encouraged by the positive Phase III data for the on-body injector, which demonstrated comparable efficacy to IV TEPEZZA and supports a clear path to subcutaneous administration without compromising clinical benefit. This convenient dosing option will enable TEPEZZA administration in additional sites of care and expand access for more patients in the future.

Following our launch in Japan in 2025, we expect additional global launches of TEPEZZA in 2026 and beyond. TADNIO sales were $119 million in the first quarter, up 32% year over year driven by strong volume growth. Since its launch in 2021, more than 8,000 patients have been treated with Tavneos, and Jay will comment on recent regulatory events in just a few moments. Our innovative oncology portfolio, which consists of Blincyto and Deltra, Vectibix, Kyprolis, Lumicraz and Enflate, grew 25% year over year generating $1.8 billion of sales in the first quarter. INDELTA delivered $258 million in first quarter sales driven by deep clinical conviction and continued adoption across care settings.

More than 1,800 U.S. sites now administer Imdeltra with a majority of doses delivered in the community setting. This progress has been supported by the combined efforts of our commercial, medical, and access teams to remove operational barriers that physicians encounter in practice, helping expand patient access to treatment. Imdeltra has become the standard of care in second-line small cell lung cancer, an aggressive disease with poor survival outcomes and few effective options to extend life. Blincyto sales were $415 million in the quarter, increasing 12% year over year, driven by broad prescribing across both academic and community settings. Blincyto is widely recognized as the standard of care in combination with multi-agent chemotherapy for patients with Philadelphia chromosome-negative B-cell ALL.

Our biosimilar portfolio delivered 14% year-over-year growth, generating $835 million in sales in the first quarter. PABLUE, our biosimilar to EYLEA, delivered $280 million in first quarter sales. Adoption continues to expand among retina specialists who appreciate PABLUE’s ready-to-use prefilled syringe and Amgen Inc.’s track record of manufacturing biologics and delivering reliable supply. Since our first product approvals in 2018, our biosimilars have generated more than $14 billion in cumulative sales, contributing meaningful growth while expanding patient access to high-quality, lower-cost biologics. Our first quarter results reflect both the strength of our key growth drivers and the commitment of our commercial, medical, and policy colleagues globally to improving the lives of patients facing serious disease.

And we remain focused on extending the reach of our medicines to even more patients in 2026. And now I will hand it over to Jay.

James E. Bradner: Thank you, Murdo, and good afternoon, everyone. Let me begin with Meritide, a new paradigm in the management of obesity, obesity-related conditions, and type 2 diabetes. The unique antibody-peptide conjugate design of Meritide delivers a potential for strong efficacy with monthly or less frequent dosing and favorable tolerability to improve long-term treatment. With existing obesity medicines, treatment burden and dosing frequency remain barriers to long-term persistence on therapy. For individuals with chronic conditions, sustained treatment is often required to realize the full health benefit of therapy. Meritide’s unique properties, particularly its potential for monthly or less frequent dosing, may help reduce treatment burden and improve persistence on treatment over time.

Towards this objective, we are excited to announce two new Phase III studies that focus on longer-term maintenance therapy with Meritide. We have initiated two long-term extensions of our ongoing Phase III chronic weight management studies to evaluate Meritide maintenance for durable weight loss. Participants who completed 72 weeks of treatment in the parent trial will enter a 48-week extension treatment period, where they will receive a monthly, every eight-week, or quarterly dose of Meritide. To date, our clinical trials have studied Meritide in the initial management of obesity and overweight. We recognize that many patients may wish to switch to Meritide from weekly injectables.

Today, we announced the initiation of another new Phase III study that will evaluate switching from weekly injectable GLP-1 therapies to Meritide following dose escalation to a convenient every eight-week or quarterly dosing schedule. Combined with our ongoing pivotal chronic weight management Phase III trials, the Meritide program will inform physicians on how to start a new patient on Meritide, and how to switch to a more convenient, less frequent dosing. Previously, we described the importance of dose escalation for improving initial tolerability with Meritide. We observed marked improvements in GI symptoms progressing from one-step to two-step dose escalation. Our accumulating experience with three-step dose escalation is quite positive.

For example, we recently completed one of our standard Phase I physiology studies in preparation for potential regulatory filings that utilized three-step dose escalation. As anticipated, three-step dose escalation further decreased the rates of nausea and vomiting as compared to prior experience with two-step dose escalation. We believe that three-step dose escalation and less frequent dosing are effective and well tolerated because of the unique antibody backbone of Meritide. The long-lived stability of an antibody creates a gentle and smooth stepwise increase in sustained drug exposure. Stable drug levels avoid the frequent peaks and troughs of daily orals and weekly injectables that may contribute to intolerability.

We remain confident and excited by Meritide, and are focused on delivering high-quality clinical data to support future regulatory filings. The studies are enrolling well, indicating strong physician and patient interest in Meritide. Meritide is emerging as a new paradigm for patients with obesity, diabetes, and related conditions as a well-tolerated first monthly or less frequently administered medicine. Turning from one major public health challenge to another, we continue to build on the landmark findings from Repatha, the prevention of cardiovascular events. In March, a new pre-specified subgroup analysis from the Phase III VESALIUS-CV trial was presented at the American College of Cardiology and simultaneously published in the Journal of the American Medical Association.

In this subset of high-risk patients with diabetes, and without known significant atherosclerosis, Repatha demonstrated a significant 31% reduction in major adverse cardiovascular events including heart attack. Repatha also demonstrated a nominal 32% reduction in the risk of cardiovascular death and a nominal 24% reduction in all-cause death. Taken together with the VESALIUS-CV data presented last fall, these findings reinforce the breadth and magnitude of benefit from Repatha in the primary prevention of cardiovascular disease. We look forward to sharing additional insights and analyses from VESALIUS with the scientific community, notably at the upcoming American Diabetes Association Annual Meeting.

Olpasiran, our potentially best-in-class small interfering RNA medicine that delivers greater than 95% reduction in Lp(a) with a quarterly dosing schedule, continues to progress in Phase III clinical investigation for secondary prevention of cardiovascular events. We have recently initiated the OCEANA CCTA study that evaluates the effect of olpasiran on the burden of non-calcified plaque in coronary arteries, as measured by coronary CT angiography. Attention to Lp(a) in medical practice is rising, reflected by the recently updated ACC/AHA lipid guidelines that now recommend broader Lp(a) testing. Moving to rare disease, we continue to build strong momentum across our portfolio. For APLISNA, we recently received European Commission approval for generalized myasthenia gravis.

Supported by a strong biological rationale, we expect to initiate two pivotal Phase III studies of aplisna in autoimmune hepatitis and chronic inflammatory demyelinating by the second half of this year. We are also advancing TEPEZZA, where we recently reported positive Phase III top-line data for subcutaneous administration via an on-body injector. These data demonstrated robust efficacy in patients with thyroid eye disease consistent with intravenous administration alongside a favorable safety profile. Subcutaneous administration of TEPEZZA represents an important step forward in improving convenience, and expanding treatment options for patients with thyroid eye disease. Dazodalibet, our first-in-class CD40 ligand-targeting fusion protein, continues to progress with two Phase III studies in Sjogren’s disease now fully enrolled.

These studies address both systemic and symptomatic disease, and both are expected to complete later this year. As publicly disclosed, the FDA proposed to withdraw the approval of Tabneos. We continue to believe that Tabneos is an important medicine for patients with ANCA-associated vasculitis, a rare life-threatening disease with limited treatment options. We are confident in the benefit-risk profile of this medicine and expect to engage further with the FDA on this topic. Turning to oncology, our bispecific T cell engager, or BiTE, platform continues to deliver meaningful impact for patients with advanced cancer.

Imdeltra is emerging as a standard of care in second-line extensive-stage small cell lung cancer, delivering an unprecedented survival benefit in a disease that has seen very little innovation for decades. As we work to advance Imdeltra into earlier lines of therapy, we are encouraged by the apparent improvement in median overall survival in the first-line maintenance setting to 25.3 months, observed in the Phase 1b DELPHI-303 study. Frontline maintenance with Imdeltra is now being studied in the ongoing Phase III DELPHI-305 study. Zeliridomig, our first-in-class STEAP1-targeting bispecific T cell engager, is advancing rapidly with two ongoing Phase III studies in metastatic castration-resistant prostate cancer.

Multiple ongoing Phase 1b studies are underway where we have taken a deliberate and differentiated approach toward earlier stages of disease to maximize long-term patient benefit. First, in biochemical recurrence, where patients experience a rising PSA without clinically evident disease, we are evaluating Xaloritomiga as monotherapy without androgen deprivation therapy. Second, we are advancing into metastatic hormone-sensitive prostate cancer, where we are evaluating zalaritamab on top of standard-of-care hormonal therapy with the goal of developing a more effective regimen without chemotherapy. One last but important note about our oncology portfolio: Following a comprehensive review, we have taken the decision to discontinue development of AMG 193, our MTA-cooperative PRMT5 inhibitor.

Over the last several years, amidst the rapid advances in artificial intelligence, we have taken a principled approach to reconsidering and augmenting drug discovery and therapeutic development. At the intersection of powerful AI models, developed both externally and internally with Amgen Inc. research, and insight-rich proprietary datasets, we are beginning to see meaningful, tangible advances across Amgen Inc. R&D. Integrated multi-omics data resources at Amgen Inc. deCODE Genetics identify new targets for therapeutic consideration, in particular non-coding regions of the human genome studied at population scale. Antibody lead optimization has accelerated by 50% from contributions both to lead discovery and lead optimization.

In clinical development, we have designed and implemented a proprietary site selection model that improves clinical trial enrollment with a significant, and in some cases up to threefold, improvement in enrollment rates. Leveraging large language models and agentic AI for regulatory filing preparation, we are seeing early promising results in data ingestion, integration, and document traffic. These are early innings. We are captivated by the potential for AI and data science to deliver measurable impact and value in R&D and across the enterprise, as Peter will highlight in a few moments.

With the retirement of our revered and beloved colleague David Reese, I am excited to lead the AI and data transformation across our business at the enterprise level, working in partnership with our leadership staff and collaborators. Let me close by saying that we are encouraged by the progress we have made in the first quarter. With a continued focus on disciplined data generation across the portfolio, with a robust pipeline and meaningful breadth and depth across four therapeutic areas, we are well positioned to deliver continued innovation for patients with long sustained value. I want to thank my colleagues across Amgen Inc. for their continued focus on patients and their commitment to advancing innovative medicines for serious diseases.

I will now turn it over to Peter for the financial update.

Peter H. Griffith: Thank you, Jay. We are pleased with our strong first quarter performance, executing through a full quarter of the patent expirations and losses of exclusivity. Our non-GAAP operating margin was 45%. We continue to invest in advancing our pipeline with non-GAAP R&D spending increasing 16% year over year in the first quarter. This reflects increased spending on our late stage by including continued investments in Meritide, IMBELTRA and opasiran. Our non-GAAP cost of sales as a percentage of product sales was 19.5%, driven by higher profit share and royalty expenses and changes in our sales mix. We expect these factors will continue to negatively impact the cost of sales in future quarters.

We further expect second quarter operating margin to be in line with the first quarter operating margin. Our non-GAAP OI&E resulted in $480 million of expense for the quarter, including a gain of about $90 million from retiring debt through open market repurchase. Our non-GAAP tax rate decreased one percentage point year over year to 13.6%, primarily due to net favorable items in the current year period, partially offset by the change in earnings mix. We generated $1.5 billion in free cash flow in the first quarter, reflecting continued momentum across the business. We spent $700 million in the first quarter on capital expenditures, driven by investments across our U.S. manufacturing sites, including Ohio, North Carolina, and Puerto Rico.

We continue to expect capital expenditures of approximately $2.6 billion in 2026, reflecting significant investment in our business to scale manufacturing capacity for volume growth, including for Meritide’s launch. We see technology and artificial intelligence as increasingly important tools to help Amgen Inc. operate with greater speed, productivity, and scale across the enterprise. Beyond what Jay described, we are also seeing tangible benefits in other parts of the business. In AI-enabled automation, it has reduced production line clearance time at one of our manufacturing sites from approximately 30 minutes to about two minutes per batch run. We are also seeing promising results as our colleagues across Amgen Inc. use AI to enhance productivity.

In addition, we returned capital to shareholders through competitive dividend payments of $2.52 per share, representing a 6% increase compared to 2025. Let us turn to the outlook for the business for the remainder of 2026. As we said last quarter, we expect 2026 to be a springboard year for future growth. Our strong first quarter performance reinforces that outlook, and we are raising our 2026 guidance ranges for both revenue and non-GAAP earnings per share. We expect 2026 total revenues in the range of $37.1 billion to $38.5 billion and non-GAAP earnings per share to be between $21.70 and $23.10. These ranges reflect our confidence that the emerging growth drivers will more than offset the outgoing legacy brands.

Note, our guidance does not include any potential business development transactions that may occur throughout the remainder of the year. Let me highlight a few updates to our outlook for the remainder of the year. For the full year, we now expect other revenue to be in the range of $1.7 billion to $1.8 billion. We now anticipate non-GAAP OI&E to be in the range of $2.2 billion to $2.3 billion of expense in 2026. We now expect a non-GAAP tax rate in the range of 15% to 16.5%. And let me remind you of prior items that have not changed.

We continue to expect the full-year non-GAAP operating margin as a percentage of product sales to be roughly 45% to 46%. This reflects our commitment to investing in the best innovation as we continue to rapidly advance the Meritide Phase III program and additional key late-stage assets. We expect share repurchases not to exceed $3 billion. Finally, in regard to our ongoing tax litigation, the tax court litigation covering tax years 2010 through 2015 remains ongoing, and while we expect a decision no earlier than the 2020, we remain confident in the case we presented at trial. We are currently under audit by the IRS for the 2016 to 2018 tax years.

In April 2026, we received a draft Notice of Proposed Adjustment, or NOPA, from the IRS for 2016 to 2018, asserting significant adjustments primarily related to the allocation of profits between the United States and Puerto Rico. The approach taken by the IRS is similar in nature to our 2010–2015 dispute with the IRS currently pending in tax court. If sustained in full, the adjustments set forth in the draft NOPA could have a material impact on our financial statements.

We disagree with the draft NOPA and have informed the IRS audit team that its draft calculation methodology is inconsistent with the positions asserted by the IRS and the Tax Court, which positions were more favorable to Amgen Inc. than the draft calculation methodology taken by the IRS audit team. We firmly believe that the IRS positions are without merit and we also believe that our tax reserves are appropriate. We intend to continue to vigorously defend our position, just as we have throughout our entire dispute with the IRS.

We remain focused on delivering sustained long-term growth and creating value for patients, staff, and shareholders by doing what we said we would do: executing on our growth drivers, advancing innovation in areas of high unmet medical need, and maintaining rigorous financial discipline. I am grateful to work with all of our colleagues worldwide in our mission to serve patients. This concludes our financial update. I will now hand it over to Bob for Q&A.

Robert A. Bradway: Thank you, Peter. Julianne, why do you not open up the lines for questions. I know it has been a long day for many of our callers, so let us jump straight in and try to get to everybody’s, or as many questions as we can. We will limit you to one question each please. But let us get started, Julianne.

Operator: Thank you. If you would like to ask a question, please press star followed by one on your telephone keypad. If for any reason you would like to remove that question, please press star followed by one again. To ask a question, press star 1. Our first question comes from Yaron Werber from TD Cowen. Please go ahead. Your line is open.

Yaron Benjamin Werber: Great, thanks so much. Maybe, Jay, unsurprisingly first question on the Meritide switch studies. Can you give us a little bit of a sense: Are you switching sort of one to one to one to months every two months and every three months? And are you looking at superiority or noninferiority? And sort of what is the noninferiority sort of margin? Thank you.

James E. Bradner: Yaron, thank you for the interest. As I just shared, people are naturally very interested to know what it will take to switch from a weekly injectable to a medicine potentially quite a bit more convenient and quite active. And so the SWITCH study is designed to provide that experience. There will be 300 subjects on study with obesity or overweight. There will be a run-in on weekly semaglutide or tirzepatide, and then they will switch to Meritide on an every eight-week or quarterly basis. The primary endpoint of this trial will be change from baseline body weight after 52 weeks of Meritide treatment. We look forward to these results. Thank you, Yaron.

Operator: Our next question comes from Salveen Richter from Goldman Sachs. Please go ahead. Your line is open.

Salveen Jaswal Richter: Good afternoon. Thanks for taking my question. Could you just comment on the Meritide switching study and why it only evaluates every two months and three months and not every one month? And then as you think about the profile today, how significant do you expect the maintenance opportunity to be for Meritide? Thank you.

James E. Bradner: Thanks. Why do I not start with the question around the design of the switch study, and then Murdo, you can talk about the opportunity thereafter. We have a lot of experience with monthly Meritide in this program, which is featured today in all of the enrolling Phase III programs. We have had a really good experience in the maintenance setting in our Phase II part two.

In that regard, the long-term extensions that we have just described, where we switch from Meritide to Meritide, give us a chance to explore less frequent dosing after effective dosing and, comparably, in the switch study, we are focusing that trial on the learnings of going from weekly to an every eight-week and every twelve-week treatment regimen, which can make Meritide quite attractive to patients if successful.

Murdo Gordon: Thanks, Jay, and thanks, Salveen. Obviously, the goal here for weight loss is to lose weight and then sustain it over multiple years so that you can get the full medical benefit of the treatment. And given that we are coming later into this market, and there will be many, many patients already on other weekly treatments, we thought it would be helpful to prescribers, to clinicians, and patients to understand how to convert, how to switch from those weekly agents to, as Jay mentioned, a more convenient regimen like Meritide.

Importantly, it will also be necessary to describe once you reach your weight loss goal on monthly Meritide, how you would want to modify that dose interval either to Q8 week or to Q12 week for even more convenience. And so we have taken the opportunity, given the timing of our launch and order of entry, to fully describe how to start patients on Meritide and then how to switch from other treatments that patients may be on and they may be dissatisfied.

Robert A. Bradway: Okay, let us go to the next question.

Operator: Our next question comes from Luca Issi from RBC Capital Markets. Please go ahead. Your line is open.

Luca Issi: Hi, Jay. Thanks so much for taking our question. This is Cassie on for Luca. We have a question for INVELTRA. The drug has clearly done very well so far in second-line setting. Can you tell us more about what is next for INVELTRA? Not only in terms of the opportunity you get once you move to the front lines, but also now with Indaltro selected as part of the real-time clinical trial pilot program, could you help us understand the process?

Is the idea basically FDA will look at your data and scientists together as a study is going, and for indications with no healthy volunteers, you essentially can go straight from first-in-human to approval without pausing for safety or end-of-phase reviews? And curious what made FDA pick INVELTRA as the pilot program? Thanks so much.

James E. Bradner: Well, let me please start. Thank you for the question. Imdeltra has really emerged as the standard of care for patients with second-line small cell lung cancer because, as I mentioned moments ago, the unprecedented efficacy afforded by Imdeltra on just the most important endpoint, overall survival. As for so many medicines in advanced cancer, medicines that work in later stages of the disease tend to confer even more clinical benefit when they are moved to earlier lines of therapy and earlier stages of lower disease burden, especially when they are used in combination. And so we are advancing Imdeltra quite actively and aggressively into frontline induction as well as frontline induction and maintenance.

The maintenance experience with Imdeltra and the frontline experience will be in extensive-stage small cell lung cancer, and these studies are rapidly progressing. Further, we have the DELPHI-306 study which studies triladumab versus placebo after chemotherapy and radiation, in frontline limited-stage small cell lung cancer. We are hopeful for these trials and just cannot wait to read them out. As you have described, we have had a chance to collaborate with Commissioner McKary and members of the FDA on imagining what a clinical study might look like in the real-world prospective practice.

And we have a very fine design coming together with the FDA that will give us a chance to characterize Imdeltra in a clinical trial setting but in the real world, leveraging things like electronic health records and real-time data capture as opposed to the way the clinical trials are conducted today. It could be a very important experiment for us and for others, because so many clinical trials initiated do not complete. Enrollment is very challenging. Managing data and packaging it and submitting it to regulators is quite a big book of work. And if there is a way to do this in more real time, we would all benefit from having this learning.

We are looking forward to working with them on that.

Murdo Gordon: Thanks, Jay. The other thing that I would add here is we have seen very good progress in where patients are treated for their small cell lung cancer with Imdeltra. We have seen really good uptake in the U.S. in community oncology. We have seen a very good launch in Japan. We expect to be launching in the second-line indication across multiple markets this year. And then, as Jay said, we have a nice randomized clinical program reading out through the balance of this year into next to further expand the use of this product. Imdeltra seems to have very durable survival as we have seen in our Phase I data.

And importantly, in these innovative trial designs that the FDA is in discussion on, this will further help the physicians, primarily those in community settings in regional hospitals or in community oncology practices, better care for their patients closer to their homes, which is a really exciting opportunity. Thank you.

Robert A. Bradway: All right. Let us move on.

Operator: Our next question comes from Michael Yee from UBS. Please go ahead. Your line is open.

Michael Yee: Thank you. Great. Maybe a question on Olpasiran. And obviously, you guys have a well-designed study and potentially superior drug. I am wondering if you think that background therapies such as GLP-1 or PCSK9 either would impact your trial design or your competitor trial design, how you think about that impacting the overall results of what we might see from a competitor soon. Thank you.

Robert A. Bradway: Jay, why do you not answer that?

James E. Bradner: Yes. Thank you for the question. We see it the same way. The OCEANA-ACE study is a very well-designed study, a randomized controlled trial of almost 7,300 patients with Lp(a) over 200 and a medicine, olpasiran, with best-in-class performance characteristics, as you cite, 95% reduction in Lp(a) with every 12-week dosing. So we are really looking forward to reading out this event-driven trial. We have built this study around a very high-risk group of patients. Elevations in Lp(a) are genetically defined, and as such, one in five individuals will have elevated Lp(a). Unfortunately, to your question, you cannot take a GLP-1 medicine or a statin, even Repatha, and meaningfully reduce levels of Lp(a).

This independent risk factor maps to a very atherogenic and inflammatory characteristic of the Lp(a)-containing particle, which is actually six times more inflammatory and atherogenic than the LDL-C containing particle, which, of course, we and others have shown to be a dramatically and importantly modifiable risk factor. And though we observed improvements in the standard of care for patients with cardiovascular disease, and we contribute to that with Repatha, we are very confident in the study as defined, which focuses on a high-risk, high-leverage elevated Lp(a) population treated with direct and targeted therapy to Lp(a) itself.

Robert A. Bradway: Okay, thank you. Let us move on.

Operator: Our next question comes from Terence Flynn from Morgan Stanley. Please go ahead. Your line is open.

Terence C. Flynn: Great, thanks for taking the question. Bob, I was just wondering, we have seen a pretty active M&A year thus far in the sector. Just as we think about Amgen Inc.’s needs, potential size of opportunity, how are you thinking about BD and M&A right now given your current needs, but also your strength and your balance sheet? Thank you.

Robert A. Bradway: Terence, I am not sure I would use the word needs the way you have in your question, but we are very active in business development as we always have been, looking for innovation that we think we can add value to. So that remains the case. I think the areas where we are interested are very clear to you and to our investors, and we will continue to see if there are things that line up in a way that we can take over programs and still add value to our shareholders. Thank you, Julianne. Next question.

Operator: Our next question comes from Geoff Meacham from Citi. Please go ahead. Your line is open.

Geoffrey Christopher Meacham: Great, thanks for the question, guys. Murdo, Repatha has been consistently strong, but I want to get some perspectives from you on penetration into primary prevention and where it could go. And as you look to the olpasiran data, how do you think primary prevention looks as a key market within the Lp(a) segment? Thank you.

Murdo Gordon: Thanks for the question, Geoff. We are really excited about what is happening in primary care. As you recall, we expanded promotion and coverage of our primary care sales team at the beginning of last year. We expanded our medical teams in anticipation, of course, of some of the news flow that we have seen: new data from the VESALIUS-CV trial that we presented last November at the AHA meeting, and then, as Jay mentioned, subsequent sub-study in diabetes patients without atherosclerosis also showing significant benefit with a 31% reduction in three-point MACE and a 31% reduction in four-point MACE. So we have a clear opportunity to help these patients who are in the care of the primary care physician.

The average diabetes patient without documented atherosclerosis is someone who is not being referred to a cardiologist, and so since the change in our label occurred actually just prior to the VESALIUS trial being presented, we have been out there talking to primary care physicians. We have seen really, really good uptake. In the quarter, we had strong overall growth in Repatha globally. If you look at new-to-brand prescription evolution in the U.S., we were up 44% in the quarter, and that is being driven by increased depth of prescribing by cardiologists and increased breadth of prescribing by primary care physicians. So very strong foundation, very pleased with the momentum.

But we still have a huge opportunity ahead of us in primary prevention promotion of Repatha, the only PCSK9 with that data generation now. So real opportunity for us. Now when we look at Lp(a), the one thing I will say that helps us is the new treatment guidelines that came out from the ACC/AHA. They have recommended that everyone who is at risk of cardiovascular disease be tested. As you know, this is a genetically determined level, so you really only need to do the test once. It is affordable. It is accessible. And so that bodes well for having some population of patients who will know their Lp(a) level.

And I do think that primary care physicians will play a significant role in treating those patients, in lowering their Lp(a) levels with, hopefully, a product like olpasiran should the data bear out.

Robert A. Bradway: Okay. Good. Let us move on to the next question.

Operator: Our next question comes from David Risinger from Leerink Partners. Please go ahead. Your line is open.

David Reed Risinger: Thanks very much. So my question is for Murdo, please. Congrats on the launch of Amgen Now. I think that occurred last fall. Could you provide some quantification on the uptake of Repatha by cash-pay patients and, I do not know if it is meaningful enough yet, but possibly the current mix of sales between cash pay and covered given the strong ramp of Amgen Now? And then, is Amgen Inc. considering leaning into offering Repatha as a cash-pay product ex-U.S.? Thanks so much.

Murdo Gordon: Thanks for the question, David. We have been pleased with overall response to the Amgen Now offering. As you will recall, Repatha is offered at a $239-a-month price point, and we are seeing cash-paying patients interested in pursuing Repatha. Now at the same time, however, it is important to note, we have opened up access substantially for Repatha, and so many patients now can access Repatha without much friction and their physician can simply attest that the patient meets the criteria for the indication of the product. So I would not expect the cash-paying component of patients going through Amgen Now to be substantial.

We are in the kind of the 8,000 to 9,000 patient range of patients moving through the Amgen Now program, and we continue to see more and more interest there. So it has been a success, but as a percentage of total Repatha, as you will note, it is relatively small.

Robert A. Bradway: Julianne, next question, please.

Operator: Next question comes from Matt Phipps from William Blair. Please go ahead. Your line is open.

Matthew Christopher Phipps: Hi, thanks for taking my questions. I was wondering on some of the blinatumomab updates. First off, you noted in the press release that enrollment has stopped in the SLE trial. Can you give us any updates on that status? And it also looks like you are pausing enrollment of the subcu administration in ALL. Any additional reasoning for that pause? Thank you.

Robert A. Bradway: Sure. Thanks, Matt. I am happy to take the question.

James E. Bradner: Blinatumomab is proving to be an important component of standard of care for adults and children with relapsed and refractory B-cell leukemia, and its current instantiation is delivered by intravenous continuous infusion. We have studied and characterized subcutaneously administered blinatumomab in the past, and there is a chance with this medicine for even higher remission rates, as we have previously shown at presentation. We observed 89–92% remission rates with manageable safety in adults with relapsed and refractory B-ALL. And so we are very encouraged by the efficacy seen with subcutaneous blin and are moving subcutaneous blin to earlier lines. As you shared, we have a potential registration-enabling Phase II initiated in adults and adolescents.

We have a Phase Ib/II study of subcu blin as well initiated in pediatric patients there with relapsed and refractory and MRD-positive B-cell ALL. As you noted, we have paused some of these studies for enrollment. BiTEs are known to have inflammatory side effects. We prioritize patient safety, especially in the conduct of clinical investigation. And observing a handful of inflammatory reactions, we are at this moment collecting some patient data and having a dialogue with the FDA. We expect to be able to open these studies back for enrollment shortly.

Robert A. Bradway: Next question, Julianne.

Operator: Next question comes from Chris Schott from JPMorgan. Please go ahead. Your line is open.

Christopher Thomas Schott: Great, thanks so much for the question. I just want to come back to Meritide. Sounds like some encouraging earlier-stage data on the titration. Are you able to provide any more color on what levels of vomiting and duration of vomiting you are seeing with the three-step titration from some of these earlier studies? Or if you cannot provide specific numbers, just maybe directionally, where that is shaking out versus a Wegovy or is that bound? Thanks so much.

James E. Bradner: Yeah, Chris, thanks. The level of nausea and vomiting observed with three-step dose escalation is lower than we have seen before. Dose escalation works for GLP-1 agonist-based therapy. That is known. In our experience, one step improved GI tolerability significantly. Two-step improved it further. And today we share the unsurprising but accumulating data that provide clinical confirmation that three-step dose escalation further improves GI tolerability. Now we await efficacy and tolerability data from the ongoing Phase III studies, but we are quite encouraged by what we have seen.

Robert A. Bradway: Jay, on the question of duration, you may help him understand what we see, help Chris understand what we see and how it is different from what we are observing from the weekly and dailies in terms of the side effect duration, side effect profile.

James E. Bradner: Before we started this research, we did not know whether a long-acting medicine like Meritide that can be delivered monthly or every eight weeks or every twelve weeks would enjoy durable efficacy owing to high time on target. This antibody backbone leads to very smooth and stable exposure over a long period of time, engaging GLP-1 receptors and GIP receptors in the brain and peripheral tissues. Would that durable efficacy be associated, when there was a side effect, with a long-term side effect? And that we do not see. When we do observe nausea and vomiting, it tends to be quite short in its duration, over the course of one or several days. No different than the weekly GLP-1s.

But different than the weekly GLP-1s and different than oral GLP-1s that are short half-life medicines. This trough-to-peak spike that is experienced every time these medicines are taken we believe can be associated with intolerable side effects in the GI and otherwise. And this can be avoided with a steady, stable, long-acting medicine like Meritide. We see this at target dosing of Meritide, by Manhattan plots versus what is reported in the field with more frequent dosing. So, in the fullness of time, this could prove to be a very important attribute, keeping patients on the medicine for the length of time that they have these diseases, which is for many of them a lifetime.

Julianne, we probably have time for two more questions.

Operator: Thank you. Our next question comes from Akash Tewari from Jefferies. Please go ahead. Your line is open.

Analyst: Hey, thanks so much. For DAZZO’s Phase III Sjogren’s programs, you are making an interesting bet, splitting it up into systemic and symptomatic patients. What kind of drove that decision? And which one of those trials are you more confident will work? And can you go over any of the biological differences between DASO and then the Novartis CD40, but also Sanofi CD40L, which both ended up discontinuing their programs? Thank you.

James E. Bradner: Yeah, Akash, I love your questions because they invite a mechanistic characterization of these molecules, but I will try to keep this brief, though it will be hard for me. We observed in Phase II very strong activity of dazodalibep, as you comment, which is a CD40 ligand Fc fusion protein targeting fusion protein. And the performance against the ESSDAI score in Sjogren’s syndrome is quite a unique situation. It has proven very hard to develop effective medicines in Sjogren’s disease. But seeing movement in the ESSDAI score made us very motivated to follow this up in Phase III clinical investigation. The presentation of this heterogeneous disease can be quite different clinically.

And so we thought to segregate, in order to have clear clinical outcomes in these clinical trials, into two Phase III studies: patients with what we will call systemic disease, but then also a separate study of moderate to high symptomatic disease, but there with low systemic disease activity. In the case that these two populations might be considered differently, we aim to observe meaningful differences attributable to those biological and clinical presentations. These studies have completed enrollment and completion of both studies is expected in the second half of this year. Dazodalibep is a product of a long-sought-after drug discovery campaign, honestly, in the field of immunology. CD40/CD40 ligand signaling is fundamental T cell/B cell co-stimulation.

CD40 ligand is on T cells; CD40 is on many, many different kinds of cells. And that makes this molecule very different than CFZ533 from Novartis. What is true of Sjogren’s disease, whether or not it is systemic or symptomatic, is that T- and B-cell activation is the primary driver. This is not a dry gland disease; it is enriched with inflammatory cells. And so we believe that CD40 ligand is the right lever to press on, as it will impact all downstream signaling by targeting the upstream CD40 ligand on T cells.

So we look forward to reading out these studies, one with the ESSDAI score, another with the ESSPRI score, appropriate for a symptomatic study, in the second half of this year. But Julianne, let us take one last question and then I will have a couple of remarks and we will be finished.

Operator: Thank you. Our last question today will come from Louise Chen from Scotiabank. Please go ahead. Your line is open.

Louise Chen: Hi. Thanks for taking my question. I just wanted to ask you, if you get Meritide approved, what are you playing for here? Do you want to be the number three player behind Novo and Lilly, or are you assuming a higher position than that with your product? Thank you.

Robert A. Bradway: Louise, that is a tempting question to consider a softball pitch over the middle of the plate here at the end of the day. But Murdo, do you want to offer any quick thoughts for Louise and then we will wrap up?

Murdo Gordon: Well, I think we are going to be the best monthly or less frequently dosed agent. But no, in all sincerity, this is a highly differentiated product. I think the opportunity is substantial to come into a market with something that really is a new paradigm-changing opportunity for a massive category.

And our focus is going to be on helping as many patients as possible in that category, whether they are de novo patients who have yet to attempt a weight loss treatment and they will be new to Meritide, or whether they are on another therapy and they are not achieving the results they like, or they are not enjoying the frequency of injections, or they are having side effects and they want to try another treatment. And we will, across the business, across the company, be ready to go into that market and compete with all of the other companies that are already there.

Robert A. Bradway: I know some of our competitors have risen to the bait of that question, Louise, but we will resist and wait instead until we have the data in hand. As you know, we are working diligently to try to generate the necessary data to register this molecule and, as Murdo said, help as many patients as possible. There are very many who need a differentiated therapy like this and we are looking forward to having the data so that we can appropriately talk to it.

But before we wrap up, as I mentioned earlier in my remarks, I just wanted to take a moment and acknowledge that Dave Reese will be retiring from Amgen Inc. at the end of the second quarter. And I wanted to thank him publicly for his contributions to Amgen Inc. over the past 20 years. As a longstanding leader and former head of R&D, Dave’s legacy here, as you all know, includes a generation of innovative medicines. What you may not be as familiar with is that Dave has been a persuasive champion for change and new technologies at Amgen Inc. and recognized, long ahead of many others, the growing importance of AI and what he called the hinge moment.

Dave both raised his hand to be Amgen Inc.’s first Chief Technology Officer and helped attract Jay Bradner to be his successor as Head of R&D. So we are thrilled and excited about the progress that we made in artificial intelligence and data under Dave’s leadership, as well as the other businesses that Dave has had responsibility for. And again, we are grateful that Jay will build on what is a very solid foundation following Dave’s retirement at the end of the second quarter. Dave is both a close colleague and friend to many of us and we will all miss him and wish him well in what we are sure will be a very active retirement.

So Dave, on behalf of all of Amgen Inc., thank you, and let me thank all of you for joining our call as well. Thank you.

Operator: This concludes our Amgen Inc. Q1 2026 earnings conference call. You may now disconnect.