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Date

Thursday, May 7, 2026 at 4:30 p.m. ET

Call participants

  • President and Chief Executive Officer — Christian Henry
  • Chief Financial Officer — James Gibson

Takeaways

  • Total Revenue -- $37.2 million, unchanged from the comparative period.
  • Instrument Revenue -- $9.7 million, representing a 12% decrease, mainly due to lower average selling prices (ASPs) for Revio and Vega systems, partially offset by higher Revio shipments.
  • Revio Systems Shipped -- 15 units, up from 12; cumulative shipments reached 346 systems.
  • Vega Systems Shipped -- 27 units, versus 28 year over year; cumulative Vega shipments now total 174.
  • Consumable Revenue -- $21.8 million, a record and up 9%, driven by over 100% growth in clinical account shipments, which now make up a mid-teens percent and have doubled their share year over year.
  • Revio Consumable Pull-Through -- Annualized at approximately $229,000 per system, in line with guidance.
  • Service and Other Revenue -- $5.6 million, a 7% decrease.
  • EMEA Revenue -- $10.8 million, up 17%, led by deeper adoption in clinical settings and higher test volumes, despite some shipment issues in the Middle East.
  • Americas Revenue -- $16.7 million, a 2% increase, supported mainly by consumable revenue and an expanding installed base.
  • Asia Pacific Revenue -- $9.7 million, down 16%, as Chinese customers deferred purchases awaiting SPRQ-Nx launch.
  • Non-GAAP Gross Profit -- $13.8 million, for a non-GAAP gross margin of 37%, down from 40%; margin decline stems from increased memory/component costs, Vega promotional pricing, and Q1-specific inventory/warranty charges.
  • Non-GAAP Operating Expenses -- $49.9 million, a decrease of 19%, including $3.8 million in share-based compensation.
  • Non-GAAP Net Loss -- $35.9 million, or $0.12 per share; improved from $44.4 million and $0.15 per share.
  • Unrestricted Cash, Cash Equivalents, and Investments -- $276 million, reflecting receipt of $48.1 million from the sale of assets to Illumina.
  • Headcount -- 492 employees at quarter-end, compared to 485 previously.
  • 2026 Revenue Guidance -- Lowered high end by $5 million; new range is $165 million to $175 million, based on continued consumable growth and persistent weakness in academic/government funding.
  • 2026 Gross Margin Guidance -- Now viewed at the lower end of a previously stated 100 to 400 basis-point improvement range, limited by rising input costs.
  • 2026 Non-GAAP Operating Expenses Guidance -- Projected at $220 million to $225 million, below prior-year levels.
  • SPRQ-Nx Beta Program -- Expanded due to "double-digit improvement in yield" and substantial early access demand, with launch set for later in the month for Revio and anticipated summer launch for Vega.
  • Strategic Asset Sale -- Closed sale of short-read sequencing assets to Illumina, resulting in $48.1 million of net cash proceeds.
  • Litigation Resolution -- Concluded outstanding legal matter with Personal Genomics of Taiwan.
  • Basecamp Research Collaboration -- Announced large-scale AI-focused project to sequence roughly 100,000 metagenomic samples for Basecamp’s Trillion Gene Atlas initiative, the largest in company history.

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Risks

  • James Gibson said non-GAAP gross margin "First quarter non-GAAP gross profit of $13.8 million represented a non-GAAP gross margin of 37% compared to a non-GAAP gross profit of $15 million or a gross margin of 40% in the first quarter of 2025. Non-GAAP gross margin decline in the quarter was impacted by 3 primary factors: First, we continue to see increased computing component costs, specifically memory, which we flagged on our Q4 call as a potential headwind in 2026 and which we believe will persist throughout the year. Second, we held a temporary Q1 promotion for Vega to drive placements, which compressed instrument margins. Third, there are unique onetime dynamics at play in Q1, including inventory adjustments and warranty-related charges. We want to be clear. Gross margin pressure in Q1 was primarily driven by nonrecurring and timing-related factors, and we expect gross margins to improve in the second quarter.
  • Christian Henry said, "instrument revenue, particularly Vega, was lower than we had expected. This was driven by continuing pressure on academic funding, particularly in the United States," noting persistent market headwinds as a structural constraint.
  • Asia Pacific revenue declined 16% year over year, primarily due to Chinese customers delaying orders in anticipation of the SPRQ-Nx commercial launch.
  • 2026 revenue guidance reduced by $5 million at the high end in response to "dynamics that Christian cited," including soft Vega demand and a challenging funding environment.

Summary

Pacific Biosciences (PACB 14.54%) reported flat total revenue, with record consumable sales offsetting declines in instrument and service revenue. Gross margin compressed due to higher memory costs, lower Vega pricing, and Q1-specific charges, but management anticipates improvement as temporary factors recede and SPRQ-Nx launches. Cash flow was supported by the Illumina asset sale, enabling continued investment amid a strategic shift away from academic markets. Executives underscored over 100% growth in consumable shipments to clinical accounts, increased clinical focus in both the Americas and EMEA, and substantial traction from new collaborations—including the Basecamp Trillion Gene Atlas project and expanded rare disease initiatives. The revised 2026 guidance reflects a cautious near-term outlook, emphasizing consumable-led growth and limited academic/government funding recovery.

  • Management highlighted aggressive strategic pivoting toward clinical and commercial customers as academic segment contribution wanes.
  • SPRQ-Nx is expected to reduce customer costs while raising company gross margin on consumables as adoption grows.
  • Clinical accounts are now the largest contributors in the Americas, illustrating a material business mix shift.
  • EMEA growth stems from rare disease whole-genome sequencing gaining status as a first-line test across multiple countries.
  • Basecamp’s project will leverage HiFi sequencing for foundational AI biology models, marking new application territory.
  • Vega ASPs are expected to normalize after the conclusion of Q1 promotional pricing, with no similar discounts planned going forward.
  • Majority of 2026 consumables guide is anchored to ramping utilization from current customers, with incremental upside possible via SPRQ-Nx-driven orders.
  • Executives expressed confidence in continued expansion in the clinical end market, targeting more than half of consumables revenue to be clinically driven over the medium to long term.

Industry glossary

  • ASPs (Average Selling Prices): The mean sales price achieved per instrument, net of discounts and promotions.
  • HiFi Sequencing: PacBio’s proprietary high-fidelity long-read sequencing technology, emphasizing accuracy and variant detection in a single assay.
  • SMRT Cell: PacBio’s consumable flow cell used in sequencing runs; the Multi-Use SMRT Cell allows multiple uses per unit, improving economics.
  • SPRQ-Nx: Next-generation chemistry for PacBio’s sequencing systems, enabling multi-use SMRT Cell capability and higher throughput.
  • Pull-Through: The annual value of consumable purchases generated per installed instrument.

Full Conference Call Transcript

Christian Henry, President and Chief Executive Officer; and Jim Gibson, Chief Financial Officer. On today's call, we will make forward-looking statements, including, among others, statements providing predictions, estimates, expectations and guidance. You should not place undue reliance on forward-looking statements because they are subject to assumptions, risks and uncertainties that could cause our actual results to differ materially from those projected or discussed. Please review our SEC filings, including our most recent Form 10-Q and 10-K and our press releases to better understand the risks and uncertainties that could cause results to differ. We disclaim any obligation to update or revise these forward-looking statements, except as required by law.

We also present certain financial information on a non-GAAP basis, which is not prepared under a comprehensive set of accounting rules and should only be used to supplement an understanding of the company's operating results as reported under U.S. GAAP. Reconciliations between historical U.S. GAAP and non-GAAP results are presented in our earnings release, which is available on the Investors section of our website. For future periods, we're unable to reconcile non-GAAP gross margin and non-GAAP operating expenses without unreasonable effort due to the uncertainty regarding, among other matters, certain acquisition-related items that may arise during the year. A recording of today's call will be available shortly after the live call in the Investors section of our website.

Those electing to use the replay are cautioned that forward-looking statements may differ or change materially after the completion of the live call. I will now turn the call over to Christian.

Christian Henry: Thank you, and good afternoon, everyone. Our first quarter of 2026 was highlighted by record consumable revenue, greater than 100% year-over-year growth in consumable shipments to clinically focused accounts and significant progress on our strategic objectives, including entering our first significant AI-related project with Basecamp Research. On the other hand, instrument revenue, particularly Vega, was lower than we had expected. This was driven by continuing pressure on academic funding, particularly in the United States. Additionally, we were unable to deliver some products to the Middle East because of the conflict in the region. I'll start by diving into our consumable performance. Once again, we achieved record consumable revenue, marking our third consecutive record quarter.

In Q1, this was highlighted by more than 100% year-over-year growth in shipments to clinically focused accounts. This growth offset the fact that some customers held off consumable shipments to wait for the SPRQ-Nx commercial launch. Overall, consumable revenue grew 9% year-over-year, and clinical shipments now represent a mid-teens percentage of total consumable shipments, doubling year-over-year. We expect clinical shipments to continue growing as customers transition from testing and validation to full commercialization. Consumable pull-through was within our expected range of $225,000 to $250,000 Revio system. Additionally, there was strong demand to participate in our SPRQ-Nx early access program during the quarter. Turning to instruments.

We shipped 15 Revio systems in the first quarter compared to 12 in the first quarter of 2025. While Revio demand remains constrained by the funding environment in the Americas, we are encouraged by the fact that half of Revio placements went to new customers globally, and we continue to see multisystem orders from clinical accounts building their capacity. We ended the quarter with cumulative Revio shipments of 346 systems. We shipped 27 Vega systems in the first quarter compared to 28 in the first quarter of 2025. The revenue contribution from Vega was impacted by 2 primary factors: lighter demand in the United States, where academic funding remains under pressure and promotional pricing geared towards attracting new customers.

Specifically, during the quarter, we launched a limited time Vega promotion to expand our Vega installed base and unlock several new accounts. We concluded the promotion at the end of the first quarter, and we expect Vega ASPs to normalize in the second quarter. The good news is that more than 85% of Vega placements went to new customers this quarter, expanding the reach of HiFi sequencing. Cumulative, Vega shipments stand at 174 systems. From a regional perspective, EMEA was a highlight in the first quarter, delivering 17% year-over-year growth. We are seeing clinical customers who were in pilot and validation mode now make the transition into sustained production scale sequencing.

That shift is creating demand for more Revio placements and is driving sustained consumable pull-through. The EMEA pipeline for Revio continues to be strong, and we believe that instrument sales in EMEA will remain an important driver for our business. As we saw in 2025, we expect that EMEA will be the fastest-growing region in our business in 2026. In the Americas, we continue to aggressively shift our strategy to clinical and commercial accounts where the funding dynamics are more favorable. In fact, in Q1, our largest accounts are now commercial service providers and clinical accounts.

Revenue in Asia Pacific declined 16% year-over-year due primarily to our largest customers in China waiting for the commercial launch of our SPRQ-Nx kits, which are expected to ship later this month. Looking ahead, we remain confident in delivering revenue growth for the year. Although Vega demand remains softer than we anticipated, Revio opportunities are increasing with the imminent launch of SPRQ-Nx. As I communicated previously, we believe the introduction of SPRQ-Nx makes HiFi sequencing the most affordable long-read sequencing technology. These favorable economics have been enabled by both the Multi-Use SMRT Cell and an increase in SMRT Cell yield.

We will commercialize SPRQ-Nx with the ability to use the SMRT Cell 3x, and our beta customers have seen double-digit improvement in yield. In fact, the beta program has gone so well that we significantly expanded the program in the first quarter. However, as I previously indicated, some of the customers are waiting for the full launch of the new chemistry, which will occur later this month. Ultimately, we believe that SPRQ-Nx will drive demand for both more Revio systems and more consumables, but SPRQ-Nx isn't limited to Revio. Later this summer, we expect to launch the SPRQ-Nx chemistry on the Vega platform.

On Vega, SPRQ-Nx will enable significantly more throughput, and it will unlock some of the key features of the SPRQ chemistry, including lower DNA input quantities. This will immediately increase the utility of the platform and increase its value, which we believe will accelerate demand for Vega. Now I'd like to highlight a few significant strategic developments from the first quarter and areas where we have made encouraging progress in support of our long term goals. First, we completed 2 significant strategic actions in the quarter. We closed the sale of our high-throughput short-read sequencing assets to Illumina, generating approximately $48.1 million in net cash proceeds and meaningfully strengthening our balance sheet.

Additionally, we resolved outstanding litigation with personal genomics of Taiwan. Taken together, these actions sharpen our focus, strengthen our position and allow us to concentrate entirely on what we believe to be our true competitive advantage, long-read sequencing. We are also making real progress in our clinical opportunity, which we believe remains the most compelling long-term driver of our business, with shipments to clinical accounts increasing more than 100% year-over-year. Our goal is clear: lower the barriers of adoption and enable clinicians worldwide to deliver more complete answers to patients and their families. Our core thesis is straightforward.

HiFi is the only commercially available sequencing technology that we believe can comprehensively characterize substantially all classes of variants in a single assay. As a comparison, short-read approaches require multiple tests to achieve a similar result. As demand for comprehensive genomic testing continues to grow, we're focused on expanding the clinical utility of HiFi sequencing because our system's faster time to answer, comprehensive genomic output, and altogether less expensive total testing costs can provide the insights that meaningfully change outcomes for patients. Specifically, we continue to believe that the rare disease market will be a major driver for clinical adoption of HiFi sequencing.

Of the estimated 300 million people living with a rare disease, many remain undiagnosed or misdiagnosed, which we believe to be a reflection of the limitations of historic sequencing technology. What makes the rare disease market particularly compelling from a business perspective is that we believe we are in the early phase of the adoption curve. Patients getting sequenced today represent a small fraction of those who could benefit. It is clear to our team that we are in the early innings of a very large opportunity, and we have the chance to make a big impact with HiFi technology. We've made notable progress across our recently announced collaborations in rare disease.

Ambry Genetics is on track to assess 1,000 patients in their once study. With Ambry, we believe we are proving that HiFi has the power to find what other sequencing technologies have missed. Our collaboration with n-Lorem and EspeRare continues to advance with HiFi sequencing across dozens of ultra-rare diseases. HiFi has the potential to help inform therapy recommendations, another important validation point for clinical utility beyond the initial diagnosis. Additionally, the University of Washington program studying sudden unexplained death in childhood by sequencing across 200 families is well underway, further building our evidence base.

As utilization of HiFi to sequence rare disease cases continues to expand, the ability to connect the data across customers and sites becomes a valuable tool for understanding each rare disease. This is why in late February, we announced a collaboration with DNAstack to launch the first global federated HiFi whole genome data set. Through the HiFi Solves consortium, which includes nearly 30 clinical and research institutions across 15 countries, the collaboration enables secure international research and allows genomic insights to travel across borders. Members have connected or have committed to connect more than 10,000 HiFi whole genome sequences, which would form one of the largest and most diverse federated HiFi data sets dedicated to rare disease research.

We expect that collaboration will accelerate discoveries for patients and further drive our strength in the clinical research setting. Beyond rare disease, we're seeing a tremendous opportunity in the carrier and newborn screening markets. For example, in the fourth quarter of '25, we announced the Babies and focus project led by Eurofins Genomics U.K. to sequence at least 2,000 samples. This study aims to demonstrate that long-read whole genome sequencing provides clinically meaningful improvements within a newborn screening setting, particularly in detecting complex and structural variants.

We believe that this study will generate real-world evidence at population scale that can justify adoption of long-read sequencing in newborns in national health care programs and demonstrate the value created by long-read sequencing over short-read approaches. I'm happy to report that this is advancing as planned, and we expect 1,000 samples to be sequenced on the PacBio technology between April and September of this year. We believe this work is foundational for building the evidence base for potential inclusion of long-read sequencing in a national newborn screening program in the United Kingdom. Before I turn the call over to Jim, I want to discuss our recently signed collaboration with Basecamp Research to deeply sequence approximately 100,000 metagenomic samples.

This will be the largest project using HiFi technology in the history of PacBio and the first scaled use of HiFi for the development of a biological foundation model. The team at Basecamp believes that model performance and biology scales disproportionately with data quality and diversity, not just model size. As a result, Basecamp is ambitiously targeting to create a Trillion Gene Atlas, which may end up expanding known genetic diversity by as much as 100-fold by sequencing up to 100-plus million species globally.

The Trillion Gene Atlas will be used to train a new class of biological foundation model, Basecamp's Eat-in model, which is already demonstrating the ability to move beyond simple prediction into generative biology, designing therapeutics directly from sequence and disease prompts, including gene insertion systems, antimicrobial peptides and cell therapies with high experimental hit rates. Basecamp selected PacBio for this groundbreaking project because HiFi technology offers the most accurate and comprehensive view of the genome, which will be critical for this new class of biological foundation model.

Additionally, with the launch of SPRQ-Nx, we now have the ability to not only sequence at scale, but also offer the economics required to meet the needs of ambitious projects like the Trillion Gene Atlas. I look forward to keeping you updated on this project as we expect sequencing to begin scaling up over the course of 2026. I'll now hand the call over to Jim, to detail our financials. Jim?

James Gibson: Thank you, Christian. I'll discuss non-GAAP results, which include noncash stock-based compensation expenses. I encourage you to review the reconciliation of GAAP to non-GAAP financial measures in our earnings press release. Unless otherwise noted, all growth rates are year-over-year. We reported total revenue of $37.2 million in the first quarter of 2026, roughly flat compared to $37.2 million in the first quarter of 2025. Instrument revenue in the first quarter was $9.7 million, a 12% decrease from $11 million in the first quarter of 2025. The year-over-year decline was primarily driven by lower Revio ASPs as we continue to prioritize placements in strategic accounts and lower Vega ASPs associated with our Q1 promotion.

This dynamic was partially offset by an increase in Revio instruments shipped. In total, we shipped 15 Revio systems and 27 Vega systems, bringing cumulative shipments to 346 Revio systems and 174 Vega systems. Turning to consumables. Revenue reached a record $21.8 million in the first quarter, up 9% from $20.1 million in the first quarter of 2025. Annualized Revio pull-through per system was approximately $229,000, reflecting consistent utilization across an expanding installed base. Finally, service and other revenue declined approximately 7% to $5.6 million in the first quarter compared to $6 million in the first quarter of 2025. From a regional perspective, Americas revenue of $16.7 million increased by 2% year-over-year.

The performance was primarily driven by growth in consumables revenue related to an increase in our installed base. For Asia Pacific, revenue of $9.7 million decreased by 16% compared to the first quarter of 2025. The year-over-year decline reflected a weaker academic funding environment and the fact that some of our Chinese service providers are waiting for the launch of SPRQ-Nx. EMEA revenue of $10.8 million increased by 17% compared to the first quarter of 2025 despite some challenges delivering product to the Middle East. The year-over-year increase was driven by consumables demand, reflecting both account expansion and higher utilization, particularly in clinical settings where increased test volumes drove incremental pull-through. Moving down the P&L.

First quarter non-GAAP gross profit of $13.8 million represented a non-GAAP gross margin of 37% compared to a non-GAAP gross profit of $15 million or a gross margin of 40% in the first quarter of 2025. Non-GAAP gross margin decline in the quarter was impacted by 3 primary factors: First, we continue to see increased computing component costs, specifically memory, which we flagged on our Q4 call as a potential headwind in 2026 and which we believe will persist throughout the year. Second, we held a temporary Q1 promotion for Vega to drive placements, which compressed instrument margins. Third, there are unique onetime dynamics at play in Q1, including inventory adjustments and warranty-related charges. We want to be clear.

Gross margin pressure in Q1 was primarily driven by nonrecurring and timing-related factors, and we expect gross margins to improve in the second quarter. Non-GAAP operating expenses were $49.9 million in the first quarter of 2026, representing a 19% decrease from non-GAAP operating expenses of $61.7 million in the first quarter of 2025. Operating expenses in the first quarter of 2026 included noncash share-based compensation of $3.8 million compared to $8 million in the first quarter of 2025. Regarding headcount, we ended the quarter with 492 employees compared to 485 at the end of 2025.

Non-GAAP net loss was $35.9 million, representing $0.12 per share in the first quarter of 2026 compared to a non-GAAP net loss of $44.4 million, representing $0.15 per share in the first quarter of 2025. We ended the first quarter with approximately $276 million in unrestricted cash, cash equivalents and investments compared with $280 million at December 31, 2025. Our cash position reflects the January closing of the sale of intellectual property and other assets related to our short-read DNA sequencing technology to Illumina for which we received $48.1 million in net cash proceeds. Turning to 2026 guidance.

Given the dynamics that Christian cited, we are lowering the high end of our outlook for 2026 revenue by $5 million and now expect revenue in the range of $165 million to $175 million. Our revised outlook continues to assume that consumables are the primary driver of growth, supported by continued utilization from clinical customers and the ongoing expansion of the Revio and Vega installed base. We continue to assume no meaningful recovery in academic and government funding, particularly in the Americas. We expect non-GAAP gross margin improvement in 2026 to be towards the lower end of our previously communicated range of 100 to 400 basis points.

While higher consumable mix and the introduction of SPRQ-Nx remain important drivers of margin expansion, rising compute costs will temper the pace of margin improvement in the near term. Non-GAAP operating expenses are expected to be in the range of $220 million to $225 million, down from 2025 levels. I'll now hand it back to Christian, for closing remarks.

Christian Henry: Thanks, Jim. The first quarter certainly had its challenges. But when I look at what we have accomplished to start the year, record consumables revenue, continued sequential strength in EMEA, increasing clinical adoption, the Basecamp Trillion Gene Atlas win and the promising results of our SPRQ-Nx beta program, which will enable full commercialization later this month, I see that we are executing on the initiatives that are expected to drive meaningful sustained growth. We are well positioned to advance the field of sequencing, making an impact for the better and delivering long-term value across stakeholders. We believe that HiFi sequencing remains the most comprehensive and accurate way to sequence the genome.

We remain focused on increasing the adoption of HiFi through both increasing the throughput of the sequencers and dramatically improving the economics of leveraging the technology through SPRQ-Nx. With these improvements, we expect to continue creating new opportunities and expanding our clinical opportunity, especially. Additionally, HiFi is increasingly becoming recognized as an obvious choice as large data sets are created to train advanced AI models for drug discovery. As a result, I'm confident in the trajectory of our business and growth as we advance through 2026. We look forward to updating you as the year continues to unfold. With that, we will now open it up for questions. Operator?

Operator: [Operator Instructions] The first question comes from Dan Brennan with TD Cowen.

Unknown Analyst: [ Pradeep ] on for Dan. What does your guide for instruments imply? And what sort of visibility do you have going forward?

Christian Henry: Can you repeat the first part of the question for me?

Unknown Analyst: Yes. What does your guide for instruments imply for the rest of the year?

Christian Henry: Yes. So our guide for instrument, the guide for instruments continues to be strengthening Revio's and a little bit of uncertainty around the Vega platform. Vega, we're finding, particularly in the Americas, is really more sensitive to the academic and government funding environment. And as we've turned our focus to really driving clinical and commercial accounts, we're seeing more demand for the Revio system. And so on balance, we expect them to somewhat balance out, and that's why you can see in the guide, we still believe we're going to achieve -- we're going to still be in the range of the guide that we provided back in February.

From a visibility perspective, we do have funnels for both platforms of course. The platform for Revio has been improving. And Vega, particularly in the Americas, has been a bit more challenging. And so that's kind of where we sit today.

Unknown Analyst: Can you discuss clinical traction, including U.S. versus outside U.S.? And what does progress in the U.S. look like and outlook for 2026 and even 2027?

Christian Henry: Yes. So U.S. versus the U.S., if we look at clinical traction, I'll start outside the United States because really, we're seeing in EMEA, very, very strong traction with the Vega platform being really the platform for whole genome sequencing for rare disease. And we're seeing the customers in EMEA go from the validation phase to increasing full commercialization. And so we expect that to be an important core driver. In the United States, we're actually seeing much of the same thing. And one of the things we said in our written remarks is that our biggest customers now have become the clinical and commercial accounts.

And what's exciting about that is those clinical accounts -- some of them have gone commercial, but many of them are kind of ending their validation phase at this point in time. And we expect to see them ramping in full commercial production with both the carrier screening assays as well as whole genome sequencing in the rare disease setting. So we do expect our growth prospects in clinical to continue and quite frankly, keep moving forward, both in the United States and in Europe, in particular. So very encouraging results. We also indicated that we saw over 100% growth quarter year-over-year for the clinical side of our business and consumables, which will help us all around.

Operator: The next question comes from Doug Schenkel with Wolfe Research.

Unknown Analyst: This is [ Austin ] on for Doug. Just a quick one on input costs. Within cost of product sales, what is your exposure to memory pricing? And given the rise in memory chip costs, are you expecting a material gross margin headwind? And if so, how should we think about the impact on margin cadence for the rest of the year?

Christian Henry: Yes, it's a great question. Thank you, Austin. We do -- our instruments are heavy compute instruments, both for DRAM and for storage as well as GPUs. We've mitigated some of that risk over the for 2026, but we do expect that to impact our gross margin some this year. And as Jim pointed out, we expect to be more on the lower end of gross margin growth than the higher end of gross margin growth really as a result of these input costs. So they are having an impact. There's a lot of variability there. We're seeing prices increase pretty regularly here. And so we're managing it. But we're managing it through.

We already have supply on hand, and we're also looking at R&D solutions, which take a bit longer to get into the system, but over the long run, as DRAM prices kind of normalize, those R&D solutions actually will help us with gross margin in the long run. So in the short run, we're managing it will have some impact in 2026. We still are expecting to improve our gross margins over 2025. And in the long run, R&D solutions will help us lower those costs overall.

Unknown Analyst: Great. And then just one on the discounting you mentioned. Where did ASPs for Revio's and Vegas land in the quarter? And are there any similar discounting activities planned for the rest of the year? Or should we expect improving ASPs from here?

Christian Henry: Yes. We -- there are no additional discount programs that are ongoing or going forward. That Vega was really a onetime promotion. And what we were trying to do with that promotion is get some new accounts, and we are very successful at that. 85% of the Vega sales were to brand-new customers. But we've decided to kind of back off of that discount in Q2. Revio ASPs are reasonably consistent with where they've been and Vega was certainly lower this quarter because of that promotion. We would expect Vega to return to kind of more normalized levels in Q2.

Operator: The next question comes from Kyle Mikson with Canaccord Genuity.

Unknown Analyst: This is [ Alex ] on for Kyle Mikson. So I understand you're facing 2 pressured instruments, but I'd like to focus on some areas of strength and potential growth. Just to start here, congrats again on the consumables growth in the quarter. Aside from rare disease, you had your pure target panels. Any plans to launch additional pure target panels in the near term? And of course, it's no secret that you shifted a good deal of focus towards the clinical end market. Do you have any internal targets regarding where you can envision what clinical might make up as a percentage of total revenue in the medium- to long-term?

Christian Henry: Yes. Those are great questions, and we're actually very happy with the pure target performance that we've had with the company, and that's really enabling us to get into the carrier screening market, for example. Where we're seeing the fastest growth though in clinical really is in a whole genome context in rare disease. But the pure target panel itself is great for carrier screening. We are developing variations of it, so that customers can customize their panels somewhat, which I think will help spread that opportunity out for us.

And when we start to look at the long run, we do believe that a very substantial proportion of our business, perhaps as much as more than half of our consumable revenue over time will be clinically driven. And we'll reserve to figure out when does that actually occur.

But we are certainly seeing that the clinical business is making up for some of the weakness in the academic segment, particularly on the consumable side, and we're very happy to see that we've got 3 sequential quarters in a row of record consumables which I think will -- not only is demonstrating the power of the platform, but it's also going to, in the long run, help our gross margins as that product mix continues to improve.

Of course, the one thing I will also say is with the imminent launch of SPRQ-Nx, SPRQ-Nx, because of its multi-use capability is one of those rare situations where we can improve the economics for the customer, but we can also increase our gross margin for consumables. And so as that product starts to take hold over the second half of the year and into 2027, that's another real opportunity for gross margin expansion. So very excited about what's going on in consumables right now.

Unknown Analyst: Great. And just one more for me. This is on the upcoming ultra-high throughput sequencer. So just thinking about multiple dynamics here in the near to medium term, the launch of SPRQ-Nx and the reusable SMRT Cells. But also you have customers thinking about this ultra-high throughput sequencer as well. So how should we factor that into potential slowdown of Revio orders near the ultra-high throughput launch as well as the benefit you're going to get from the full broad commercial launch of the reusable SMRT Cells. Moreover, do you envision yourself as a multiple product tools vendor in the long term? Or realistically, do you think maybe ultra-high throughput and Vega would become the main stage of the portfolio?

And perhaps what is customer feedback on potential new sequencers indicated to you about how you think about this dynamic?

Christian Henry: Yes. It's an interesting question. And what our strategy has been is that we believe we need that having 3 platforms in the market gives customers a lot of choice for what levels of volume that they want to pursue. What our intent is, is to keep improving the Revio platform through improvements to the reagents to the consumables, which is what we've done with the SPRQ chemistry and now with SPRQ-Nx chemistry, we will keep creating more value for those Revio customers.

That said, for those customers that want to operate at very significant scale, the ultra-high throughput system will be the way to go because it will be -- it will drive cost down for them in terms of not only the economics of the sequencing, but the logistics and everything behind that. And so over the long run, we believe that all 3 platforms will find their place in the market with the mid-throughput kind of customers being long-term Revio users. And then, for example, the larger clinical accounts all moving to the ultra-high throughput. Vega will continue to improve as well.

As I said in my written remarks, we're going to increase the throughput pretty substantially later this summer and also introduce all of the features of SPRQ, so Ultra or so low DNA input amounts, for example. And that will add value to that platform and help it become a mainstay. It is -- it will have the right level of throughput for lots of different applications like AAV and microbial and other types of applications like that. So we do think it will find its footing not only in the academic setting, but perhaps in some of the -- some aspects of the clinical market as well.

So we see very strong prospects for all 3 platforms in the market going forward.

Operator: The next question comes from David Westenberg with Piper Sandler.

Unknown Analyst: This is [ Peron Patel ] on for David. Maybe just one on EMEA growth. Maybe could you characterize the type of clinical applications that are driving that growth? Is it primarily rare disease germline? Or are you seeing meaningful contribution from oncology rare disease?

Christian Henry: Yes. So we grew 17% in EMEA. So we're really pleased with how EMEA is moving forward. And it really is on the back of rare disease testing in going -- becoming first-line tests in different countries. Structurally, Europe is a perfect market for us and for Revio for this, a single-payer health care system with a lot of innovative leaders that have really gotten behind the fact that with long-read sequencing and particularly HiFi, you can eliminate several other tests relative to short-read approaches and you can increase your diagnostic yield at the same time. And so they're demonstrating this in multiple countries now, and we're starting to see that push.

That's really what really what is propelling our growth in that part of the world right now. Interestingly, they grew substantially even though we did have some challenges getting some shipments out to the Middle East, which would have counted in the EMEA scorecard. So that region is really doing quite well, and I fully expect it to be our fastest-growing region again in 2026.

Operator: The next question comes from Mason Carrico with Stephens.

Mason Carrico: Maybe first, within the 2026 guide, how much visibility do you have today into consumable revenue that's baked in maybe from the existing installed base ramping utilization versus consumables associated with maybe new placements this year?

Christian Henry: Yes, that's a great question. And the reality is that we have -- most of our guide is predicated on existing customers and their utilization because here we are in May. And as we place new systems, there is a ramp-up time for utilization, particularly if they're going to have a meaningful contribution to consumables in 2026. So when you think about the guide, we're really taking the majority of it coming from existing customers as they grow and expand. The launch of SPRQ-Nx is the one variable that we are evaluating, and we'll see how that unfolds over the next 2 or 3 months as we kind of get that off the ground.

As I did say, some of our customers held off their shipments in March for regular SPRQ reagents in anticipation of the SPRQ-Nx launch. And so I suspect as some of those -- as we get SPRQ-Nx out to market, some of those customers perhaps will place bigger orders earlier, which will help us and get us off and moving. But overall, when we think about the visibility to the guide in consumables, it really is driven off of the existing installed base, what we know about the existing installed base expanding their utilization and then to a lesser extent, the new placements of instruments that we expect. Hopefully, that helps.

Mason Carrico: Yes. No, that's really helpful. And -- we're juggling a few tonight, so sorry if you've talked about this, but could you share any additional feedback on the Vega promotional program in Q1 and how we should be thinking about Vega placements for the balance of the year? I think you had a high percentage of new customers in Q1 for Vega. How much of that demand was driven by that promotional program?

Christian Henry: Yes. The promotional program was successful. It's always difficult. Once you put a promotion in place, it's always difficult to know which customers would have purchased the system without the promotional price. But we did have a substantial portion of our 27 units shipped under the promotion. And where the promotion was most successful was in APAC, in particular, where that's certainly a more price-sensitive market. And so we're seeing that.

But it also kind of gave us some insight that it really is a tough academic and -- academic and government tough funding environment, particularly in the Americas because even with the promotion, there wasn't that many customers that took advantage of the promotion in the United States, and it's really due to funding. And so it helped us understand that a little better. When I think about going forward demand, I do think that the funnel allows us to kind of certainly achieve our guidance. That's why we put the guidance out the way we did. And I do think that Vega will be volatile from quarter-to-quarter. It typically is. It varies.

If you look at last year, the numbers varied quite a bit. But I do expect us to start moving in a more normalized direction with respect to ASPs, and we'll see how the unit volumes react to that.

Operator: This concludes our question-and-answer session. I would like to turn the conference back over to Christian Henry, for closing remarks.

Christian Henry: Yes. Well, I appreciate everyone's participation on today's call. We look forward to providing you updates at the various conferences this quarter and on our next call, and we appreciate your support of PacBio. So have a great day.

Operator: The conference has now concluded. Thank you for attending today's presentation. You may now disconnect.