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DATE
May 12, 2026 at 4:30 p.m. ET
CALL PARTICIPANTS
- President and Chief Executive Officer — Mary T. Szela
- Chief Financial Officer — David Patience
- Medical Director — Dr. Richard Marshak
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TAKEAWAYS
- Revenue -- $8.9 million, down from $9.2 million, attributed explicitly to commercial organization transition.
- Gross margin -- 86%, up from 84%, driven by lower average unit cost and manufacturing improvements.
- Research and development expenses -- $3.2 million versus $3 million, with approximately $500 thousand from non-cash stock-based compensation.
- Sales and marketing expenses -- $7.4 million versus $6.7 million, reflecting costs from expanding the commercial footprint, onboarding, and training.
- General and administrative expenses -- $5.4 million versus $5.2 million, with $1.3 million of non-cash stock-based compensation.
- Net operating loss -- $8.4 million versus $7.3 million, reflecting lower revenue and increased commercial investment.
- Adjusted EBITDA loss -- Approximately $5.8 million compared to $5.5 million in the prior year.
- Cash and cash equivalents -- $56.6 million as of March 31, 2026, representing full funding of strategic plans.
- 2026 revenue guidance -- Revised to $54 million to $57 million, citing Q1 revenue impact from commercial expansion and delayed FDA clearance for TriNav Advance.
- FDA status for TriNav Advance -- Review is five months past the 30-day MDUFA review goal; clearance still expected in the second half but with no second-half launch revenue included in guidance due to uncertainty.
- Commercial organization expansion -- Sales territories more than doubled, with significant new leadership and onboarding completed as of May, including additional management layers for both hospital and payer outreach.
- Landmark PEDD real-world evidence study -- Data set includes 603 PEDD patients (515 TACE, 88 TARE) from a 300 million patient claims database and 16,200+ controls; published outcomes showed fewer complications, fewer hospitalizations, and $7,700 per patient cost avoidance.
- Key PEDD clinical results -- Statistically less fatigue (20.9% vs. 26.4%), nine-fold reduction in lymphopenia at high adoption centers (0.6% vs. 5.2%), over 48% more doxorubicin delivered per PEDD procedure, and 30-day inpatient admissions less than half (8% vs. 20.5%) for TACE group.
- Other emerging applications -- Retrospective analysis in uterine artery embolization showed 97.5% median dominant fibroid volume reduction versus 50% historical comparator; thyroid study demonstrated a 73% reduction in nodule size and normalization of function in 71% of patients.
- PEDD market opportunity -- U.S. addressable market of approximately $2.5 billion across liver and new non-liver applications stated as target for commercial focus.
- Nalotolimod program -- PERIO-1 consolidated readout targeted for 2026, combining three dose escalation studies and ongoing investigator data into a single dataset.
SUMMARY
TriSalus Life Sciences (TLSI 5.24%) reported a sequential revenue decline attributed specifically to the disruption from a major commercial expansion rather than demand softness. Management revised full-year guidance downward due to the combined effects of Q1 transition-related revenue drag and a multi-month FDA review delay for TriNav Advance, which removed late-year launch revenue from projections. A landmark, peer-reviewed real-world evidence study demonstrated PEDD’s statistically significant clinical benefits and cost avoidance in liver tumor therapy, supporting ongoing commercial adoption efforts. Management confirmed that the expanded sales force is now fully staffed and trained, with productivity gains expected throughout the year, and highlighted upcoming clinical trial catalysts across multiple new anatomical applications.
- The FDA review of TriNav Advance remains delayed by five months beyond normal benchmarks, with no confirmed timeline for clearance or market launch guidance in the second half.
- Retrospective data published in uterine artery embolization showed exceptional clinical results, which management stated are rarely seen in interventional medicine.
- Strong physician enthusiasm and validation from community and academic clinicians was directly stated as a driver in the adoption of PEDD.
- Management explicitly committed to advancing the nalotolimod and pancreatic PEDD programs through partnership models and reconfirmed unchanged strategic priorities in these segments.
INDUSTRY GLOSSARY
- PEDD (Pressure Enabled Drug Delivery): A technology for enhanced delivery of therapeutics to tumors, designed to improve drug penetration and outcomes in embolization procedures.
- TACE (Transarterial Chemoembolization): A procedure used to treat liver tumors by delivering chemotherapy directly to the tumor via the hepatic artery and blocking the tumor’s blood supply.
- TARE (Transarterial Radioembolization): A liver-directed treatment using radioactive beads delivered through blood vessels to target tumors.
- GAE (Genicular Artery Embolization): A minimally invasive technique for treating knee osteoarthritis by reducing blood flow to areas of inflammation within the knee.
- TAE (Thyroid Artery Embolization / Transarterial Embolization): An embolization procedure for non-oncologic conditions, such as thyroid nodules or certain benign and malignant neoplasms.
- MDUFA (Medical Device User Fee Amendments): U.S. regulation setting user fee targets and review timelines for medical device submissions to the FDA.
- Nalotolimod: An investigational immunotherapeutic agent developed by TriSalus Life Sciences targeting immuno-oncology applications in combination with pressure-enabled delivery.
Full Conference Call Transcript
Mary T. Szela, president and chief executive officer David Patience, chief financial officer; and Dr. Richard Marshak, medical director. Mary will provide an overview of our first quarter results and our strategy for the balance of the year. David will then walk through the financial results in detail. Dr. Marshak will join Mary and David for the Q&A portion of the call. Earlier today, TriSalus released its financial results for the quarter ended 03/31/2026. A copy of the press release is available on the TriSalus Investor Relations website. Today, TriSalus also announced the public real-world evidence study evaluating the clinical and economic impact of our pressure enabled drug delivery or PEDD technology. Mary will discuss that study in detail.
Before we begin, I would like to remind you that during today's call, management will make forward-looking statements within the meaning of the federal securities laws. These statements are made pursuant to the safe harbor provisions of the Private Securities Litigation Reform Act of 2000. Any statements other than statements of historical fact including, without limitation, statements regarding our sales and operating trends, business and hiring prospects, financial and revenue expectations, and future product development and approvals are forward-looking. They are based on current estimates and assumptions and involve material risks and uncertainties, including the impact of macroeconomic conditions and global events, that could cause actual results to differ materially from those anticipated.
You should not place undue reliance on these statements. For a description of the risks and uncertainties associated with our business, please refer to the risk factors section of our forms 10-Q and 10-K on file with the SEC and available on EDGAR as well as our other periodic filings. TriSalus disclaims any obligation except as required by law to update or revise any forward-looking statement whether due to new information, future events, or otherwise. This call contains time sensitive information and is only as of today's live broadcast 05/12/2026. And with that, I will turn the call over to Mary.
Mary T. Szela: Thank you, Jeremy, and good afternoon, everyone, and thank you for joining us. I will cover 4 topics today. First, our first quarter results. Second, the deliberate realignment and significant expansion of our commercial organization, creating a foundation to cap the multiyear growth that a cadence of new clinical and health economic evidence will unlock over the next 18 months. Third, our updated 2026 guidance and the outlook for the balance of the year. And fourth, in my view, the most important news of the quarter: the publication of landmark real world evidence on PEDD. The largest study of its kind ever conducted. Demonstrating fewer complications, fewer hospitalizations, and roughly $7.7 thousand per patient in cost avoidance.
This is meaningful news for TriSalus, and more importantly, for the patients we serve. David will then provide a detailed financial review and we will take your questions. As we previewed on our 2025 year-end call, our 2026 plan called for a disciplined investment in commercial infrastructure designed to deepen physician engagement, extend our footprint to cover new applications, and lay the foundation for future growth. And it is why we raised capital this quarter. After several years of significant growth, our territories were expanding beyond what individual representatives and our sales leaders could cover effectively And the gap was widening as the new applications began to emerge.
Continuing to operate at the prior scale, was simply not a path to capturing the full opportunity ahead of us. In the liver embolization market or the new applications. we are entering. The investment had 3 core dimensions. New commercial leadership, a meaningful expanded talent base across sales leadership, field management, and clinical specialist roles, a realigned significantly larger field footprint that scales for future growth. Anchoring the expansion is Chris Sowd, who recently joined us as senior vice president of sales and commercial operations. Chris brings more than 20 years of commercial leadership in diagnostics and life sciences. With senior roles at Roche, Ventana, Luminex, and most recently, Accelerate Diagnostics, where he led US commercial.
He has a proven track record of building and scaling high performing field organizations and securing strategic partnerships with leading health systems. An important initiative we wanna pursue. Chris is precisely the operator we need to lead our commercial organization through this next phase of growth, and we are fortunate to have him on our team. As of May, the new significantly expanded sales organization is largely in place. As with any expansion of this scale, Q1 revenue reflects the transition, the costs of territory realignment, representative onboarding, representative time out of the field for training, and the rebuilding of account relationships.
And roughly 60% of our territories, where the rep to physician relationship remained intact, sales performed in line with expectations. And the remaining 40%, we deliberately modified 2 critical relationships at the same time. Rep to physician and rep to manager. Both our primary drivers of execution and unit volume and modifying them simultaneously was the right strategic choice. We expect sales productivity to improve steadily throughout the balance of the year complemented by growing contributions from new clinical data, new account capture, and penetration into new applications. Q1 performance was not a function of softer demand or any change in the underlying fundamentals of our business.
It reflects the deliberate cost of a build out phase investing now in the commercial engine required to scale this organization for our next phase of growth. We are revising our full year 2026 revenue guidance to a range of $54 million to $57 million The driver of this revision includes both the lower Q1 revenues from the commercial expansion, and the delayed FDA clearance timing for TriNav Advance. Our next generation device was extends PEDD capability to small distal vessels via microcatheter. FDA review of TriNav Advance is now running 5 months past the 30 day MDUFA review goal.
We have been in active dialogue with the FDA, and while we still expect clearance in the second half of the year, we are taking a prudent approach to forecasting the launch given the inherent unpredictability of clearance timing and the appropriate market evaluation period that follows. This timing shift removes our advanced revenue expectations from the second half of the year due to the clearance delay. We remain enthusiastic about the launch. TriNav Advance creates an incremental market opportunity by enabling interventional radiologists to access the benefits of PEDD using the microcatheter of their choice. Today, physicians who employ a super selective approach prefer to track to the site of delivery with their existing microcatheter.
TriNav Advance meets them where they are already in practice. Revising guidance is an adjustment that TriSalus team nor high take lightly We remain fully committed to our investors, and to executing against the goals we set We believe taking a measured posture on TriNav advance is the right 1. Once Advance is in our hands, we will have a complete portfolio supporting the full range of liver embolization procedures. I wanna spend a moment on the development of quarter that matters most for TriSalus and, more importantly, the patients we serve. Today, we published the largest real world evidence study of PEDD ever conducted.
It includes 603-PEDD patients matched against more than 16.2 thousand non-PEDD patients drawn from a 300 million patient population based claims database covering 96% of US payers with data spanning January 2020 through March 2024. The cohort comprises 515-TACE patients and 88-TARE patients. Making it the largest TARE PEDD dataset ever published and the most comprehensive PEDD dataset across both embolization modalities. The analysis used a rigorous 2-stage matching design coarsened exact matching paired with propensity score matching applied to both the overall cohort and to each modality subgroup. The headline result was compelling.
Despite higher baseline disease burden the data is demonstrating that PEDD is simply not a device, but a highly differentiated therapeutic delivery capable of improving liver embolization outcomes. Reducing health care utilization, and expanding treatment possibilities across multiple indications. PEDD treated patients achieved statistically better outcomes across every measure. 4 takeaways stood out. Number 1, less fatigue and preserved immune function. Across the full cohort. Significantly less post procedure fatigue across the full cohort, 20.9% versus 26.4%. Roughly, 9-fold reduction in lymphopenia at high adopter centers. 0.6% versus 5.2%. Preserving lymphocyte counts is clinically critical since lymphopenia is a known barrier to downstream immunotherapy.
Bottom line: PEDD patients leave the procedure with their immune systems more intact, and remain eligible for follow on immunotherapy treatment. Number 2, lower 30 day readmissions in the TACE subgroup, Driven by significantly improved tumor targeting. PEDD delivered approximately 48% more doxorubicin per procedure. PEDD procedures had 30 day inpatient admissions cut by more than half. 8% with PEDD, versus 20.5% without. Bottom line: direct evidence of improved tumor targeting with less off target toxicity. Number 3, the more a center uses PEDD, the better the outcomes. At top 5% adoption facilities, the lymphopenia gap widens further and further and liver metastatic outcomes improve sharply across both the TACE and TARE practice patterns.
In secondary liver metastases, patients at high adopter centers fatigue was cut by more than half. 19.2% versus 39.7%. And lymphopenia was nearly eliminated. 0% versus 8.2%. Bottom line: the more a center uses PEDD across either TACE or TARE, the better the outcomes get. Call adoption and institutional experience compound the benefit. Number 4, downstream cost avoidance. Per patient cost avoidance of approximately $7.7 thousand across the full 603-patient PEDD cohort. Roughly $3.1 thousand from fewer inpatient stays and $4.6 thousand from fewer post procedure complications. Cost avoidance holds across both care and TACE, and is not isolated to 1 modality.
Higher and more durable response rates may further reduce total procedures per patient compounding the economic benefit over time. Bottom line: PEDD effectively reduced downstream costs in both TACE and TARE cases. This large landmark publication validates what we have been saying for years about the clinical rationale for PEDD and it does so in patients representative of everyday clinical practice. For our physician customers, it reinforces that the investment in PEDD competency pays compounding dividends. For our commercial team, it is a peer reviewed evidence at scale that accelerates institutional adoption. Beyond this publication, we continue to generate new clinical evidence on the patient impact of PEDD.
We now have 10 active studies underway across 24 clinical sites generating data on more than 400 TriNav-treated patients. 2 new prospective investigator initiated trials are set to begin enrollment this quarter. Study called pressure at Stanford is a randomized study of TriNav and TARE for liver metastases comparing tumor absorbed dose response rate and disease control to the current standard delivery. Predict, at MD Anderson, a prospective study evaluating PEDD impact in hypovascular tumors. Both are designed to generate exactly the kind of prospective head-to-head data that drives clinical adoption at top academic centers. We are also preparing to publish results from 2 completed investigator initiated trials, the TETHER study at Massachusetts General Hospital.
And TRI-FI 90 at MD Anderson both have completed data analyses are targeting publication submission this quarter. We believe these readouts will be a meaningful catalyst for second half commercial momentum. Lastly, we initiated 2 large retrospective studies during the quarter, examining TriNet delivered TARE in HCCs. This will provide cost efficient evidence on outcomes, and target populations and will provide the basis of the clinical trial design of our larger prospective clinical trials we plan to initiate in 2026. Beyond liver, we continue to build meaningful momentum across our new applications: uterine artery embolization, thyroid artery embolization, and genicular artery embolization, each a significant independent growth factor. At SIR in 2026, Dr.
Francis King of Rutgers Robert Wood Johnson Medical School presented a retrospective analysis of PEDD in uterine artery embolization. The headline is the kind of number you rarely see in interventional medicine. Median dominant fibroid volume reduction of 97.5%. Versus a historical literature comparator of approximately 50%. This is a step change in clinical effect achieved with less embolic material and shorter procedure time. Exactly what you would expect from a more targeted delivery mechanism. The study also reported 100% technical success with no device related complications and sustained reductions in pain and heavy menstrual bleeding at both 1- and 6-month follow-up.
In Q1, we approved expanding the study to 50 patients, and we are actively designing a prospective trial to further evaluate TriNav's potential to streamline workflow. Reduce procedure and fluoroscopy time, and improve outcomes in uterine artery embolization. Our PROTECT Registry continues to roll across multiple centers, evaluating PEDD for patients with thyroid nodules or goiters, who are not candidates for conventional therapy. Preliminary results published in the Journal of Endocrine Society demonstrate 100% technical and clinical success. A 73% reduction in thyroid size, and normalization of thyroid function in 71% of participants with no neurovascular complications. These are remarkable results for minimally invasive outpatient procedure.
In February, doctor Juan Camacho and his colleagues published a review of thyroid artery embolization in seminar in interventional radiology, highlighting PEDD's unique ability to enhance distal distribution and reduce the need for carotid circulation catheterization. We now have enrolled more than 50% at our 11 sites who are actively recruiting patients. PROTECT is on track to deliver the first multicenter US data on thyroid artery embolization and to position PEDD-TAE as the leading approach for this procedure. We just concluded a pilot registry, and now are preparing to launch a formal clinical trial evaluating genicular artery embolization for knee osteoarthritis, a condition affecting more than 30 million adults in the United States.
GAE represents a novel, minimally invasive approach to pain management and mobility preservation with the potential to delay or avoid knee arthroplasty in appropriate patients. This is an emerging field we believe our PEDD platform is uniquely positioned to drive the clinical rigor needed to establish it as standard of care. Collectively, these indications represent a US addressable market of approximately $2.5 billion, and we are methodically building both the clinical evidence base and the commercial infrastructure to address all of them. A brief update on our nalotolimod program. Remain on track to deliver our consolidated PERIO-1 readout in 2026.
As a reminder, that readout will combine data from 3 completed dose escalation studies along with emerging data from an ongoing investigator initiated study. And deliver them as a single complete dataset rather than a series of sequential partial releases. This approach reflects our commitment to a rigorous, internally validated package, 1 we believe will most clearly demonstrate the program's potential. The timing is not driven by any safety signal, or by any efficacy concern or by any change in our strategic priorities. In parallel, we continue to advance our broader pancreatic strategy.
Pancreatic cancer remains 1 of the most significant unmet needs in oncology, and we believe our novel pancreatic PEDD device is uniquely suited to overcome the delivery barriers that have long limited therapies in this disease. As we prepare to share the nalotolimod data, we are also building the case for PEDD as an adjunct to current and next generation pancreatic regimens. We expect to have more to share as the year progresses. Our commitment to both nalotolimod and our broader pancreatic program is unchanged.
Consistent with the strategy we previously communicated we intend to advance these programs through a partnership structure, 1 designed to preserve their long term value while maintaining the capital discipline required to fund our near term commercial and clinical priorities. Before I turn the call over to David, let me summarize where we stand and what we are building towards. Entering the remainder of 2026, we have a substantially expanded commercial organization in place poised to accelerate multiyear growth. The most significant real-world evidence dataset in our history published in a peer reviewed journal confirming the statistically significant clinical and economic value of PEDD at scale. And a pipeline of new applications and clinical readouts that build throughout the year.
Our near term milestones include generating differentiated clinical data across UAE, TAE, and GAE, releasing a nalotolimod data update in the second half, delivering our full year 2026 revenue of $54 million to $57 million. And lastly, subject to FDA clearance, launching TriNav advance in the second half. We are executing against all of these priorities from a position of financial strength with the growth capital we raised in Q1 fully supporting our strategic road map. I remain deeply confident in our team, our platform and the long term value we are creating for both patients and shareholders. With that, I will turn the call over to David.
David Patience: Thank you, Mary. and good afternoon, everyone. Let me walk through the results for the first quarter ended March 31, 2026. Revenue, for the first quarter was $8.9 million compared to $9.2 million in the prior year period. The lower revenues were due to the transition related to the expanded commercial organization. Gross margin for the quarter was 86% compared with 84% in the prior year period. The improvement was driven by lower average unit cost on TriNav and our continuous manufacturing improvement. Research and development expenses were approximately $3.2 million compared to $3 million in the prior year period. The increase was driven by noncash stock based compensation expense.
The current period includes approximately $500 thousand of non-cash stock based compensation expense. Sales and marketing expenses were approximately $7.4 million compared to $6.7 million in the prior year period. The increase reflects our deliberate investment in expanding our commercial footprint, including headcount, onboarding, expanded training and territory development costs associated with the sales force expansion. The current period includes approximately $500 thousand non-cash stock based compensation expense. General and administrative expenses were approximately $5.4 million compared with $5.2 million in the prior year period. The increase was driven by higher noncash stock based compensation expense. The current period includes approximately $1.3 million of such expense.
Consistent with prior years, we expect first quarter G&A expenses to be higher than subsequent quarters as many annual public company expenses materialize in the first quarter. Net operating loss for the quarter was $8.4 million compared to $7.3 million in the prior year period. The increase reflects 2 factors. Lower revenue from the commercial expansion and a deliberate increase in sales and marketing investment associated with our commercial expansion. Adjusted EBITDA loss for the quarter was approximately $5.8 million compared to $5.5 million in 2025. As of 03/31/2026, cash and cash equivalents totaled $56.6 million. In closing, the fundamentals of the business are strong.
Gross margins remain durable in the mid-80s, and our cash position fully funds our strategic growth plan. The investment we made in Q1 in our commercial organization and as we continue to make in PEDD clinical evidence are foundational and will compound. They allow TriSalus to scale successfully and fully execute for the next phase of growth. We look forward to demonstrating that progress as the year unfolds. Thank you all for your continued support, And with that, operator, we will open the line for questions.
Operator: Thank you. And wait for your name to be announced. To withdraw your question, please press 1-1 again. 1 moment for questions. And our first question comes from Frank Takkinen with Lake Street Capital Markets. You may proceed.
Analyst (Frank Takkinen): Was hoping to start with 1 on the quarter and then kind of forward-looking from there. On the quarter, maybe specifically, the 40% called out that were disrupted in the Salesforce, can you help quantify just maybe how much disruption that caused? And then maybe more importantly, as you are looking at the business now and as you were exiting the quarter, and into second quarter now, what can you tell us to give us a little bit of confidence really in the recovering trajectory of the business to achieve the guidance range, for the year.
Mary T. Szela: So hi, Frank. How are you? So let me let me talk first about the 60%. So 60% of our sales territories were not disrupted. And we saw them perform as expected. Think of that as a control group. So we are very comfortable that there is been really no fundamental change in demand no fundamental change in terms of the--and continued growth in the business. Now in the remaining 40%, we changed 2 dynamics. We changed rep-to-manager and rep to physician. And it was largely a result of just our growth. You know, it got to the point where the territories had grown so substantially that it was inadequate for those reps to cover them.
So that caused some disruption in sales because we disrupted those territories. We also had some new reps coming in, which was time out of the field. So that was the driver of Q1 performance. We are largely in place today, and we are really happy with what we are seeing. You know, I have been through many different sales expansions in the past. You always have a short term hit when you make these transitions. But if you do it in the right way, which I think we have the right talent, the right territory footprint now, we will start to see that ramp continuously throughout the rest of the year.
Analyst (Frank Takkinen): Okay. that is helpful. And then maybe as my follow-up, I think last call, you were talking about effectively doubling the sales organization. Maybe an update related to that. Have you achieved that level of hiring? Is there still a portion that needs to be hired to hit that doubling? And if that is the case, maybe when will that is that expected to be complete?
Mary T. Szela: Yeah. Thank you for asking that question. 1 of the things that occurred during Q1, this was largely due to the capital raise, just the level of talent of who we were attracting to the company was really unprecedented for us. And that drove us to make the decision to slightly expand even further. than what we originally envisioned. So, you know, we are doubling of the organization, but we think that was the right decision to make at this point. We have just enormous growth potential. You know, a $2.5 billion market across liver and all the new applications.
So we now have the right footprint of organization, the right combination of management, clinical specialists, reps, that really allow us to scale this company far beyond where we are today.
Analyst (Frank Takkinen): Okay. that is helpful. I will hop back in queue.
Mary T. Szela: Thank you. Thank you.
Operator: Our next question comes from William Plovanic with Canaccord Genuity. You may proceed.
Analyst (William Plovanic): Hey. Great. Thanks. Good evening. Thanks for taking our questions. Just like to start out first, I was wondering if you could level set us with what was the composition and size of the commercial organization prior to the expansion and kind of numbers, where does that sit now as we look at, you know, managers like, you know, VP, regional managers, territory managers, that are quota carrying, and then, obviously, the clinical. Kind of what were those kinda numbers generally pre- and post this transition?
Mary T. Szela: So Hi, Bill. How are you? We are not giving specific numbers but let me give it to you in a qualitative standpoint. Over the last 3 years, we have been adding kind of very marginally a couple reps at a time. We had really started to stretch the manager to rep relationship where it got above double digits, which was too much. So in this new reorganization, we expanded the number of territories, more than double.
We also really changed the rep to manager level, and then we added another executive level management, which we think is really important because in light of the data that we are producing, we now have the opportunity for them to reach out to hospital systems and payers We think this is going to be an important catalyst for us as we move forward because the data is so strong. So we now have an organization that sized for the full 400 accounts. That we wanna pursue both in the liver and the new applications.
Analyst (William Plovanic): And it sounds like this started in early March and you feel like you completed this by May. What is the typical ramp time for a rep And then how should we think about revenue cadence for the year? Is Q2 up year-over-year? Kind of my numbers it is probably gonna be down closer to about $10.5 million. And then, you know, the ramp through the rest of the year, because I think you mentioned the cadence would be pretty linear and consistent, at least I mean, those are my words, not yours, but that was my takeaway. Thanks. Yep.
Mary T. Szela: No. You are exactly right. We typically see with our reps. Now the talent of these reps are just outstanding. We see a 6- to 9-month ramp. All the reps are largely in place. So we are we anticipate for the remainder of the year just to see month-over-month continual growth. And I think we have been really reasonable in our assumptions. However, what we are seeing is some of these reps come out of the gate pretty strongly. I will hand it over to David to talk about the ramp, but we feel confident about the rest of the year.
The caliber and the quality of these reps that we were attracting just to give you a little bit of color on that, we never were really able to get people away from the big companies who have been there 15, 18 years that is the type of reps that we were getting here that were coming to us. Just deep you know, relationships with the interventional radiologist, a lot of interventional radiology knowledge really excited about the company and where we were going. We think that is gonna bode well in terms of performance throughout the year.
David Patience: Yeah, Bill. This is David. And to provide some context on the second half of the year, you know, we are thinking about exactly the expansion and the fact of the doubled size is largely in place, and that includes both reps that carry quotas and specialists that are also in the territory supporting those quotas as well. And so as that productivity is ramping, you know, we also are bringing online additional capacity. And that is what is going to drive the step-up, from prior periods in the second half of the year. We are very excited about the capacity that we have built.
We feel that the second half ramp is structurally built, we are very excited to see those reps start contributing in a meaningful way.
Analyst (William Plovanic): But, David, how should we think about Q2? I mean, I think with the reset, we just wanna make sure that we are thinking the same way you are And, you know, any comments on the 10 and a half estimate or number I am thinking of?
David Patience: Yeah, Bill. For the second quarter, we are thinking that would be marginal sequential gain quarter over quarter as these--as these reps are coming out of training. I think where you are is a fair point, and then we would see that meaningful progress as they reach Productivity, you know, in Q3 and Q4.
Operator: Thank you. And as a reminder, to ask a question, please press Our next question comes from Justin Walsh with JonesTrading. You may proceed.
Analyst (Justin Walsh): Hi. Thanks for taking the question. I would love to hear your thoughts on where you see the new PEDD data having the most direct impact. I am curious about the balance of clinical versus economic benefit and how that will resonate with physicians and institutions to help drive additional adoption.
Mary T. Szela: Really good question. I think we are really proud of this data. In fact, we, right before this call, just got off a call with 1 of the physicians who I would characterize as really the father of interventional radiology and I think what we are starting to see in this specialty is really begin to value the real world data. How does this technology work not only in the, expert academic centers, but how does it work across all the community centers? And the way he characterized this data, he was just incredibly enthusiastic. And I will have Dr. Marshall talk about it as well. is just validates a lot of our prospective clinical data.
So together, this dataset with all the other studies that we have conducted, it just strengthens that this delivery platform is really significant, and it has both clinical--both clinical benefits and cost effective data. And we believe by building this database that is so interrelated in this way, that we can begin to create a dataset that really creates this as standard of care and the inclusion in the NCCN guidelines. Dr. Marshak, you want to comment on it? Because I think as a practicing interventional radiologist, I think you will have some thoughts on this data as well.
Richard Marshak: I do. I think the most interesting part about this data is that it is real data. And this is from physicians who have been practicing. This is not prospective study that is designed with tight parameters to ensure good data. This is actually what is happening in the US. And so it does validate a lot of the things that we have been saying. The things that we know about TriNav. And it is a different way of thinking about looking at data and interventional radiology, and this is something that we see large drug companies do, is use HEOR data to help understand the economic value of their products.
So we are shining a light on some of the things about interventional interventions that these procedures bring to patients.
Mary T. Szela: And I thought I would comment on 1 aspect that I thought was really profound and that we have heard from some of the other interventional radiologists who have looked at the data. 1 of the things in terms of having no effect on lymphopenia, that to oncologist has been resonates really strongly. And 1 of the things that is critical in these treatments, there is always been a question about whether embolization can be used in combination with some of the other immunotherapy regimens. If you have elevation in liver enzymes, if you have lymphopenia, often that could disrupt a patient's treatment.
When they saw this data, this is just giving them validation that this type of approach can be really impactful for patients and they do not have to disrupt the treatment. And this is the first time we have had this type of data before. So we think this could not only impact the interventional radiology community, we think it could have real impact in the oncology community as well.
Analyst (Justin Walsh): Great. Thanks for taking the question.
Operator: Thank you. I would now like to turn the call back over to Mary for any closing remarks.
Mary T. Szela: Well, thank you for your time today. I really appreciate it. Thank you again for the support of the company.
Operator: Thank you. This concludes the conference. Thank you for your participation. You may now disconnect.
