Please ensure Javascript is enabled for purposes of website accessibility

Momenta Pharmaceuticals Contemplates Its Future

By Brian Orelli, PhD - May 15, 2018 at 1:49PM

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More

The company is undergoing a strategic review to determine its priorities.

After a delay in launching Glatopa 40 mg resulted in competition, Momenta Pharmaceuticals (MNTA) has decided to conduct a strategic review to determine where it should put its limited cash resources -- presumably partnering or selling the remaining less-important assets -- making for a rather abstract first-quarter earnings update.

Momenta Pharmaceuticals results: The raw numbers


Q1 2018

Q1 2017

Year-Over-Year Change


$4.85 million

$26.61 million


Income from operations

($49.0 million)

($32.6 million)


Earnings per share




Data source: Momenta Pharmaceuticals.

What happened with Momenta Pharmaceuticals this quarter?

  • Revenue decreased year over year due to lower sales of Glatopa 20 mg, the daily version of Teva Pharmaceutical's (TEVA -4.63%) multiple sclerosis drug Copaxone, after Mylan (MYL) got its version of the drug approved. There was also a $9.8 million deduction from the 50% partnership with Novartis (NVS -1.30%) for inventory reserves for Glatopa 40 mg, the three-times-a-week version.
  • Despite the competition, Novartis still has 40% of the 20 mg market, but the competition has resulted in lower prices.
  • Momenta and Mylan, which in addition to being competitors for Copaxone generics are also partners for their biosimilar program, continue their investigation into why M834, a copycat of Bristol-Myers Squibb's Orencia, failed a phase 1 trial in November. 
  • After discussing plans with the FDA, Momenta said it's going to run proof-of-concept studies testing M281, which lowers immunoglobulin G (IgG) levels, in two different diseases. One trial will be in a disease for which lowering IgG levels has already been shown to help patients, such as myasthenia gravis, idiopathic thrombocytopenic purpura, or pemphigus. And for the second trial, the plan is to test M281 in a disease for which there is no currently approved treatment, potentially allowing a quicker route to approval, albeit with potentially more risk.
Diagnostic form with multiple sclerosis written on it. A book, medications, and a thermometer are scattered on top.

Image source: Getty Images.

What management had to say

Craig Wheeler, Momenta's president and CEO, explained why the biotech plans to test M281 in a disease for which the drug's mechanism of action has already been determined to be beneficial: "Our goal is to demonstrate the potential of our molecule in an area where the target has been validated and hopefully demonstrate that our higher potency and strong safety profile translates into best-in-class efficacy."

Wheeler also highlighted a preclinical drug, M254, with high potential that will enter phase 1 trial in the second half of the year:

In animal models, we can reproducibly demonstrate up to 10 times the potency of IVIG [intravenous immunoglobulin]. If we can do this in humans, it will be a game-changer for the IVIG marketplace, which today is a global supply constrained market with over $4 billion in sales in autoimmune indications. IVIG in autoimmune indications is a very difficult therapy for patients, often requiring infusions over one or more days with challenging side effects. A drug with a fraction of the volume and infusion time and with the potential to dose higher for better efficacy could create meaningful value for patients and our investors.

Looking forward

Momenta plans to complete its strategic review by the end of this quarter, so investors won't have to wait too long to see what's on the chopping block. Once the biotech extends its cash runway, it'll just be a waiting game as the company's pipeline of biosimilars and proprietary drugs make it through the clinic, and hopefully on to the market in a few years.

Invest Smarter with The Motley Fool

Join Over 1 Million Premium Members Receiving…

  • New Stock Picks Each Month
  • Detailed Analysis of Companies
  • Model Portfolios
  • Live Streaming During Market Hours
  • And Much More
Get Started Now

Stocks Mentioned

Momenta Pharmaceuticals, Inc. Stock Quote
Momenta Pharmaceuticals, Inc.
Teva Pharmaceutical Industries Limited Stock Quote
Teva Pharmaceutical Industries Limited
$7.83 (-4.63%) $0.38
Novartis AG Stock Quote
Novartis AG
$84.17 (-1.30%) $-1.11
Viatris Inc. Stock Quote
Viatris Inc.

*Average returns of all recommendations since inception. Cost basis and return based on previous market day close.

Related Articles

Motley Fool Returns

Motley Fool Stock Advisor

Market-beating stocks from our award-winning analyst team.

Stock Advisor Returns
S&P 500 Returns

Calculated by average return of all stock recommendations since inception of the Stock Advisor service in February of 2002. Returns as of 06/29/2022.

Discounted offers are only available to new members. Stock Advisor list price is $199 per year.

Premium Investing Services

Invest better with The Motley Fool. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services.