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Here's Why Exelixis Stock Is Dropping Today

By Cory Renauer - Jun 28, 2021 at 12:04PM

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The company reported successful clinical trial results, but investors were still disappointed.

What happened

Shares of Exelixis (EXEL -1.02%), an oncology-focused biopharmaceutical company, started sliding Monday in response to a disappointing clinical trial readout. Investors responding to results that weren't quite good enough have shaved 20.1% from the stock's price as of 11:30 a.m. EDT. 

So what 

Along with collaboration partner Ipsen (IPSEY -1.49%), Exelixis announced top-line results from the Cosmic-312 trial, which evaluates the use of cabozantinib in previously untreated liver cancer patients. This kinase inhibitor is approved as Cabometyx to treat liver cancer patients who have already relapsed following standard treatment, and is the company's only source of revenue right now.

Investor watching a stock chart.

Image source: Getty Images.

Cabometyx is also approved to treat first-line kidney cancer patients, but sales aren't growing as fast as investors would like them to. Total first-quarter revenue rose 19% year over year to $270 million this year and increasing its addressable patient population to include new first-line liver cancer patients could lead to a significant revenue bump.

Treatment with Cabometyx plus Tecentriq from Roche reduced patients' risk of disease progression by 37% but the observed overall survival improvement fell short of statistical significance. The FDA could approve an expansion to the first-line setting with these results. Getting oncologists to actually prescribe it without proof of an overall survival benefit, though, would be an uphill battle.

Now what

Exelixis and Ipsen intend to keep running the Cosmic-312 study until completion, which will probably occur in 2022. It doesn't happen often, but there's still a chance that final overall survival results from this study will redeem Cabometyx plus Tecentriq as a first-line treatment option for liver cancer.

Exelixis shareholders should hang on tight and bargain shoppers might want to take a closer look. Following the recent beating, shares have been trading at just 7.5 times sales. This year, Exelixis expects sales and royalties from cabozantinib to reach between $1.15 billion and $1.25 billion. At the midpoint, that's 22% more than the company reported in 2020.

Cory Renauer has no position in any of the stocks mentioned. The Motley Fool recommends Exelixis. The Motley Fool has a disclosure policy.

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Stocks Mentioned

Exelixis, Inc. Stock Quote
Exelixis, Inc.
$19.31 (-1.02%) $0.20
Roche Holding AG Stock Quote
Roche Holding AG
$41.64 (0.17%) $0.07
Ipsen S.A. Stock Quote
Ipsen S.A.
$23.89 (-1.49%) $0.36

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