Express Scripts Holding (Nasdaq: ESRX) is expected to report Q3 earnings around Oct. 26. Here's what Wall Street wants to see:

The 10-second takeaway
 Comparing the upcoming quarter to the prior-year quarter, average analyst estimates predict Express Scripts Holding's revenues will increase 137.3% and EPS will increase 25.3%.

The average estimate for revenue is $27.46 billion. On the bottom line, the average EPS estimate is $0.99.

Revenue details
 Last quarter, Express Scripts Holding notched revenue of $27.69 billion. GAAP reported sales were much higher than the prior-year quarter's $11.36 billion.

Source: S&P Capital IQ. Quarterly periods. Dollar amounts in millions. Non-GAAP figures may vary to maintain comparability with estimates.

EPS details
 Last quarter, non-GAAP EPS came in at $0.88. GAAP EPS of $0.21 for Q2 were 68% lower than the prior-year quarter's $0.66 per share.

Source: S&P Capital IQ. Quarterly periods. Non-GAAP figures may vary to maintain comparability with estimates.

Recent performance
 For the preceding quarter, gross margin was 7.7%, 80 basis points better than the prior-year quarter. Operating margin was 3.2%, 190 basis points worse than the prior-year quarter. Net margin was 0.6%, 230 basis points worse than the prior-year quarter.

Looking ahead

The full year's average estimate for revenue is $95.11 billion. The average EPS estimate is $3.71.

Investor sentiment
 The stock has a four-star rating (out of five) at Motley Fool CAPS, with 729 members out of 773 rating the stock outperform, and 44 members rating it underperform. Among 184 CAPS All-Star picks (recommendations by the highest-ranked CAPS members), 175 give Express Scripts Holding a green thumbs-up, and nine give it a red thumbs-down.

Of Wall Street recommendations tracked by S&P Capital IQ, the average opinion on Express Scripts Holding is outperform, with an average price target of $65.59.