GlaxoSmithKline (NYSE: GSK) is expected to report Q4 earnings on Feb. 6. Here's what Wall Street wants to see:

The 10-second takeaway
Comparing the upcoming quarter to the prior-year quarter, average analyst estimates predict GlaxoSmithKline's revenues will expand 3.0% and EPS will increase 18.0%.

The average estimate for revenue is $11.19 billion. On the bottom line, the average EPS estimate is $1.05.

Revenue details
Last quarter, GlaxoSmithKline booked revenue of $10.52 billion. GAAP reported sales were 5.3% lower than the prior-year quarter's $11.11 billion.

Source: S&P Capital IQ. Quarterly periods. Dollar amounts in millions. Non-GAAP figures may vary to maintain comparability with estimates.

EPS details
Last quarter, non-GAAP EPS came in at $0.84. GAAP EPS of $0.36 for Q3 were 16% lower than the prior-year quarter's $0.43 per share.

Source: S&P Capital IQ. Quarterly periods. Non-GAAP figures may vary to maintain comparability with estimates.

Recent performance
For the preceding quarter, gross margin was 70.2%, 80 basis points worse than the prior-year quarter. Operating margin was 27.0%, 390 basis points worse than the prior-year quarter. Net margin was 17.2%, 220 basis points worse than the prior-year quarter.

Looking ahead

The full year's average estimate for revenue is $43.23 billion. The average EPS estimate is $3.88.

Investor sentiment
The stock has a four-star rating (out of five) at Motley Fool CAPS, with 35 members out of 39 rating the stock outperform, and four members rating it underperform. Among two CAPS All-Star picks (recommendations by the highest-ranked CAPS members), two give GlaxoSmithKline a green thumbs-up, and give it a red thumbs-down.

Of Wall Street recommendations tracked by S&P Capital IQ, the average opinion on GlaxoSmithKline is outperform, with an average price target of $47.84.

This article represents the opinion of the writer, who may disagree with the “official” recommendation position of a Motley Fool premium advisory service. We’re motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.