Based on the aggregated intelligence of 180,000-plus investors participating in Motley Fool CAPS, the Fool's free investing community, pharmaceutical and diagnostics company Opko Health (NASDAQ:OPK) has received an alarming one-star ranking.

With that in mind, let's take a closer look at Opko and see what CAPS investors are saying about the stock right now.

Opko facts

Headquarters (Founded)

Miami (2006)

Market Cap

$2.0 billion



Trailing-12-Month Revenue

$36.6 million


Chairman/CEO Dr. Phillip Frost (since 2007)
Vice Chairman/Chief Technology Officer Dr. Jane Hsiao (since 2007)

Return on Equity (Average, Past 3 Years)



$42.4 million / $21.4 million


Alnylam Pharmaceuticals (NASDAQ:ALNY)

Sources: S&P Capital IQ and Motley Fool CAPS.

On CAPS, 17% of the 168 members who have rated Opko believe the stock will underperform the S&P 500 going forward.

Just last week, one of those bears, All-Star TMFBlacknGold, touched on Opko's seemingly unsustainable valuation:

I see a lot of speculation here about a buyout, but let's get back to reality. It doesn't seem likely that any company will pay over $2 billion for just $170 million in net assets and less than $40 million in annual revenue. Opko goes from a measly $5-$6 million in quarterly revenue to $11 and all of a sudden it's the best company ever? Look closer and you'll see that a near doubling in revenue resulted in an even larger loss than last year!

Want to see how well (or not so well) the stocks in this series are performing? Follow the TrackPoisedTo CAPS account.

This article represents the opinion of the writer, who may disagree with the “official” recommendation position of a Motley Fool premium advisory service. We’re motley! Questioning an investing thesis -- even one of our own -- helps us all think critically about investing and make decisions that help us become smarter, happier, and richer.