In a recent slideshow on one-drug wonders, Fool Brian Orelli pointed to three companies that have been very successful after launching their first major drug.

In the video below, he talks with Max Macaluso, the Fool's health care bureau chief, about three companies: Chelsea Therapeutics (UNKNOWN:CHTP.DL), MannKind (NASDAQ:56400P706), and Durata Therapeutics (UNKNOWN:DRTX.DL), which are looking to launch their first drug if the FDA agrees.

Chelsea Therapeutics is on its second attempt to have its low blood pressure medication Northera approved. MannKind is on its third attempt for its inhaled insulin Afrezza. And Durata Therapeutics is up for an FDA approval for its antibiotic Dalvance.