Accessibility Menu
CytomX Therapeutics logo

CytomX Therapeutics(NASDAQ) CTMX

Current Price$3.35
Market Cap$724.95MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.
Since IPO (2015)-74%
5 Year-40%
1 Year+39%
1 Month+10%
CytomX Therapeutics last closing stock price
MetricPriceDate
Last closeUSD 3.332026-07-22
CytomX Therapeutics stock price return by period
PeriodPrice returnPrice at period startPeriod start date
1 week-9.51%USD 3.682026-07-15
1 month+9.54%USD 3.042026-06-22
3 month-25.17%USD 4.452026-04-23
Year to date-21.83%USD 4.262025-12-31
1 year+39.33%USD 2.392025-07-22
3 year+86.03%USD 1.792023-07-21
5 year-40%USD 5.552021-07-23
Since inception-74.19%USD 12.902015-10-08

CytomX Therapeutics Financials at a Glance

Market Cap

$724.95MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

Revenue (TTM)

$35.54M

Net Income (TTM)

-$59.14M

EPS (TTM)

-$0.36

P/E Ratio

-9.15

Dividend

$0.00

Beta (Volatility)

1.16 (Average)

Price

$3.35

Volume

32,739

Open

$3.30

Previous Close

$3.33

Daily Range

$3.28 - $3.41

52-Week Range

$1.72 - $8.21

Estimated Earnings Date

Aug 6, 2026

CTMX: Motley Fool Moneyball Superscore

63

Our CEO Is Handing Members His Secret Weapon

It's called Motley Fool Moneyball, our new proprietary AI tool

We spent over half a million dollars in R&D to build a tool that makes stock research faster, sharper, and smarter. Our analysts use it every day, and now, you can too.

Get Access Now

About CytomX Therapeutics

CytomX creates cancer drugs that only activate inside tumors. These treatments aim to kill cancer cells while sparing healthy tissue. They help patients with hard-to-treat diseases like colorectal cancer.

Targeting Tumors with Masks

  • Varsetatug masetecan (Varseta-M): Antibody-drug conjugate targeting EpCAM for solid tumors; initially focused on advanced colorectal cancer.
  • CX-801: Dually-masked version of interferon alpha-2b; currently undergoing Phase 1 testing for patients with melanoma.
  • Probody Platform: Technology platform used to create biologics that activate specifically within the tumor microenvironment.
  • CX-908: Experimental T-cell engager targeting the CDH3 protein; currently in the preclinical development stage.

Deals with Drug Giants

  • Secured an exclusive worldwide license for the EpCAM program from ImmunoGen (now AbbVie) in 2019.
  • Formed a strategic partnership with Moderna in 2022 to create mRNA-based conditionally activated therapies.
  • Partnered with Regeneron in 2022 to develop bispecific cancer therapies using the Probody platform.
  • Entered a clinical supply agreement with Merck in 2024 to test CX-801 in combination with the immunotherapy Keytruda.

Solving the Toxicity Problem

The company uses protein masks to stop drugs from binding to healthy cells, which often causes severe side effects in traditional cancer treatments. Its research platform has been in development for over 15 years and applies to multiple drug types including antibody-drug conjugates and cytokines.

The Financial Scorecard

  • Revenue was $663,000 in Q4 2025, down 98.3% from $38.1 million in Q4 2024.
  • Net income was -$26.5 million in Q4 2025, turning negative from $18.9 million in the previous year.
  • Operating income was -$27.9 million in Q4 2025, worsening from $17.7 million in Q4 2024.
  • Free cash flow reached -$23.4 million in Q4 2025, which deepened by 17.3% year-over-year.

Evolution and Outlook

CytomX has moved from early research to a clinical-stage developer of several conditionally activated cancer therapies. It maintains its pipeline through a mix of internal programs and high-profile pharmaceutical partnerships.

AI Generated • May 2, 2026

Industry

Biotechnology

Employees

69

CEO

Sean A. McCarthy, PhD, MBA

Headquarters

South San Francisco, CA 94080, US

CTMX Financials

Key Financial Metrics (TTM)

Gross Margin

99.29%

Operating Margin

-181.92%

Net Income Margin

-166.40%

Return on Equity

-36.61%

Return on Capital

-21.66%

Return on Assets

-16.46%

Earnings Yield

-10.93%

Dividend Yield

0.00%

Payout Ratio

0.00%

Stock Overview

Market Cap

$724.95MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

Shares Outstanding

217.70M

Volume

32.74K

Avg. Volume

4.26M

Financials (TTM)

Gross Profit

$35.29M

Operating Income

-$64.66M

EBITDA

-$57.67M

Operating Cash Flow

-$80.09M

Capital Expenditure

-$101.00K

Free Cash Flow

-$80.19M

Cash & ST Invst.

$346.71M

Total Debt

$2.86M

CytomX Therapeutics Performance Analysis

CytomX Therapeutics annual revenue and year-over-year revenue growth by fiscal year
Fiscal yearPeriod endRevenueYoY growth
20222022-12-31USD 53,163,00042.5%
20232023-12-31USD 101,214,00090.4%
20242024-12-31USD 138,103,00036.4%
20252025-12-31USD 76,201,000-44.8%
CytomX Therapeutics sequential (quarter-over-quarter) revenue growth by fiscal quarter
Fiscal quarterPeriod endQoQ growth
Q22025-06-30-63.4%
Q32025-09-30-68.0%
Q42025-12-31-88.9%
Q12026-03-311447.2%
CytomX Therapeutics annual diluted earnings per share and year-over-year EPS growth by fiscal year
Fiscal yearPeriod endDiluted EPSYoY growth
20222022-12-31USD -1.51-16.4%
20232023-12-31USD -0.01-99.5%
20242024-12-31USD 0.38N/A
20252025-12-31USD -0.15N/A
CytomX Therapeutics sequential (quarter-over-quarter) diluted earnings per share growth by fiscal quarter
Fiscal quarterPeriod endQoQ growth
Q22025-06-30-100.4%
Q32025-09-30-7400.0%
Q42025-12-31-88.9%
Q12026-03-3141.2%

Revenue Growth Rate

Annual and quarterly growth comparison

Earnings Per Share Growth Rate

Annual and quarterly EPS growth comparison

Quarterly Performance

Name
Q1 2026YOY CHG

Revenue

$10.26M

-79.9%

Gross Profit

$10.01M

-80.3%

Gross Margin

97.55%

N/A

Market Cap

$724.95MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

N/A

Market Cap/Employee

$10.51M

N/A

Employees

69

N/A

Net Income

-$18.25M

-177.6%

EBITDA

-$17.94M

-174.8%

Quarterly Fundamentals

Name
Q1 2026YOY CHG

Total Cash

$346.71M

+334.0%

Total Debt

$2.86M

-65.0%

Accounts Receivable

$646.00K

-67.0%

Inventory

$0.00

N/A

Long Term Debt

$0.00

-100.0%

Short Term Debt

$2.86M

-46.0%

Return on Assets

-16.46%

N/A

Return on Invested Capital

-19.87%

N/A

Free Cash Flow

-$25.55M

-20.7%

Operating Cash Flow

-$25.55M

-21.4%

Other Investments to Explore

People Also Watch

Symbol / CompanyPricePrice Chg
REPLReplimune Group, Inc.
$10.38-3.49%
DNAGinkgo Bioworks Holdings, Inc.
$7.87+0.51%
MGTXMeiraGTx Holdings plc
$12.19+0.25%
AVXLAnavex Life Sciences Corp.
$2.48-2.94%

Trending Stocks

Symbol / CompanyPricePrice Chg
TSLLDirexion Shares ETF Trust - Direxion Daily Tsla Bull 2x Shares
$7.84-0.29%
AALAmerican Airlines Group
$13.64-0.08%
TQQQProShares Trust - ProShares UltraPro Qqq
$65.75-0.06%
SOFISoFi Technologies
$16.63-0.03%

Questions About CTMX

What is the current price of CytomX Therapeutics?

CytomX Therapeutics is trading at $3.35 per share.

What is the 52-week range for CytomX Therapeutics?

Over the past 52 weeks, CytomX Therapeutics has traded between $1.72 and $8.21.

How much debt does CytomX Therapeutics have?

As of the most recent reporting period, CytomX Therapeutics reported total debt of $2.86M.

How much cash does CytomX Therapeutics have on hand?

CytomX Therapeutics reported $28.83M in cash and cash equivalents in its most recent financial results.

What is CytomX Therapeutics’s dividend yield?

CytomX Therapeutics does not currently have a dividend yield.

Premium Investing Services

Invest better with The Motley Fool. Get stock recommendations, portfolio guidance, and more from The Motley Fool's premium services.