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Silence Therapeutics Plc

(NASDAQ) SLN

Current Price$10.46
Market Cap$495.96MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.
Since IPO (2020)-46%
5 Year-59%
1 Year+69%
1 Month+55%
Silence Therapeutics Plc last closing stock price
MetricPriceDate
Last closeUSD 10.502026-07-17
Silence Therapeutics Plc stock price return by period
PeriodPrice returnPrice at period startPeriod start date
1 week+15.51%USD 9.092026-07-10
1 month+55.33%USD 6.762026-06-17
3 month+39.44%USD 7.532026-04-17
Year to date+72.7%USD 6.082025-12-31
1 year+68.81%USD 6.222025-07-17
3 year+81.03%USD 5.802023-07-18
5 year-58.82%USD 25.502021-07-16
Since inception-46.15%USD 19.502020-09-08

Silence Therapeutics Plc Financials at a Glance

Market Cap

$495.96MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

Revenue (TTM)

$921.49K

Net Income (TTM)

-$85.17M

EPS (TTM)

-$1.59

P/E Ratio

-6.59

Dividend

$0.00

Beta (Volatility)

0.71 (Low)

Price

$10.46

Volume

277,230.414

Open

$10.81

Previous Close

$10.50

Daily Range

$10.44 - $11.19

52-Week Range

$4.19 - $11.19

Estimated Earnings Date

Aug 6, 2026

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About Silence Therapeutics Plc

Silence Therapeutics develops RNA therapies for rare diseases. Its products target genes causing health issues. These therapies aim to improve patient outcomes.

Products and Services

Divesiran (SLN124): Targets polycythemia vera, a blood disorder, in Phase 2 trials.

Zerlasiran (SLN360): Aims at cardiovascular disease, with completed Phase 1 and 2 trials.

mRNAi GOLD Platform: Designs RNA molecules to silence disease genes in the liver.

Collaborations: Partners with AstraZeneca for RNA therapies in various diseases.

Hansoh Partnership: Develops RNA therapies for undisclosed targets in China.

Growth and Expansion

Partnered with AstraZeneca for RNA therapeutics in 2020.

Collaborated with Hansoh Pharmaceutical for siRNA development in 2021.

Expanded product line with Divesiran and Zerlasiran trials in 2023.

What Makes Silence Therapeutics Special

Silence Therapeutics leverages its mRNAi GOLD platform for precise gene targeting. Strategic partnerships enhance its development and commercialization capabilities.

Five Things You Need to Know

Has not generated revenue from product sales as of 2024.

Focuses on cardiovascular and hematology segments with siRNA candidates.

Faces challenges in securing additional financial resources.

Relies on third-party collaborations for development activities.

Anticipates continued significant losses, with no commercialized products yet.

Bottom Line

Silence Therapeutics is evolving through strategic partnerships and innovative RNA therapies. It remains focused on addressing rare and complex diseases.

AI Generated • Apr 16, 2026

Industry

Biotechnology

Employees

88

CEO

Iain Gladstone Ross

Headquarters

London, GL W14 8TH, GB

SLN Financials

Key Financial Metrics (TTM)

Gross Margin

66.43%

Operating Margin

-9396.64%

Net Income Margin

-9243.05%

Return on Equity

-121.71%

Return on Capital

-143.69%

Return on Assets

-73.99%

Earnings Yield

-15.17%

Dividend Yield

0.00%

Payout Ratio

0.00%

Stock Overview

Market Cap

$495.96MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

Shares Outstanding

47.23M

Volume

277.23K

Avg. Volume

392.11K

Financials (TTM)

Gross Profit

$612.12K

Operating Income

-$86.59M

EBITDA

-$78.13M

Operating Cash Flow

-$65.57M

Capital Expenditure

-$106.00K

Free Cash Flow

-$65.67M

Cash & ST Invst.

$70.08M

Total Debt

$136.00K

Silence Therapeutics Plc Performance Analysis

Silence Therapeutics Plc annual revenue and year-over-year revenue growth by fiscal year
Fiscal yearPeriod endRevenueYoY growth
20222022-12-31USD 21,557,38526.3%
20232023-12-31USD 31,765,65147.4%
20242024-12-31USD 43,276,20236.2%
20252025-12-31USD 560,306-98.7%
Silence Therapeutics Plc sequential (quarter-over-quarter) revenue growth by fiscal quarter
Fiscal quarterPeriod endQoQ growth
Q22025-06-3067.2%
Q32025-09-30-48.2%
Q42025-12-31-78.6%
Q12026-03-311139.1%
Silence Therapeutics Plc annual diluted earnings per share and year-over-year EPS growth by fiscal year
Fiscal yearPeriod endDiluted EPSYoY growth
20222022-12-31USD -1.55-15.3%
20232023-12-31USD -1.47-5.3%
20242024-12-31USD -0.98-33.2%
20252025-12-31USD -1.8891.9%
Silence Therapeutics Plc sequential (quarter-over-quarter) diluted earnings per share growth by fiscal quarter
Fiscal quarterPeriod endQoQ growth
Q22025-06-30-2.6%
Q32025-09-3045.0%
Q42025-12-3179.5%
Q12026-03-31-22.2%

Revenue Growth Rate

Annual and quarterly growth comparison

Earnings Per Share Growth Rate

Annual and quarterly EPS growth comparison

Quarterly Performance

Name
Q1 2026YOY CHG

Revenue

$421.29K

+129.3%

Gross Profit

$304.49K

+167.5%

Gross Margin

72.27%

N/A

Market Cap

$495.96MMarket cap calculated using publicly traded shares outstanding only. Does not include unlisted, private, or dual-class non-traded shares. Implied market cap may vary.

N/A

Market Cap/Employee

$5.64M

N/A

Employees

88

N/A

Net Income

-$14.93M

+59.5%

EBITDA

-$14.83M

+59.6%

Quarterly Fundamentals

Name
Q1 2026YOY CHG

Total Cash

$70.08M

-48.7%

Total Debt

$136.00K

+126.7%

Accounts Receivable

$22.22M

+31.9%

Inventory

$0.00

N/A

Long Term Debt

$43.00K

N/A

Short Term Debt

$93.00K

+55.0%

Return on Assets

-73.99%

N/A

Return on Invested Capital

-82.73%

N/A

Free Cash Flow

-$15.60M

-26.7%

Operating Cash Flow

-$15.60M

-26.8%

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Questions About SLN

What is the current price of Silence Therapeutics Plc?

Silence Therapeutics Plc is trading at $10.50 per share.

What is the 52-week range for Silence Therapeutics Plc?

Over the past 52 weeks, Silence Therapeutics Plc has traded between $4.19 and $11.19.

How much debt does Silence Therapeutics Plc have?

As of the most recent reporting period, Silence Therapeutics Plc reported total debt of $136.00K.

How much cash does Silence Therapeutics Plc have on hand?

Silence Therapeutics Plc reported $5.66M in cash and cash equivalents in its most recent financial results.

What is Silence Therapeutics Plc’s dividend yield?

Silence Therapeutics Plc does not currently have a dividend yield.

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